Abstract：
:Cerebellum development involves the coordinated production of multiple neuronal cell types. The cerebellar primordium contains two germinative zones, the rhombic lip (RL) and the ventricular zone (VZ), which generate different types of glutamatergic and GABAergic neurons, respectively. What regulates the specification and production of glutamatergic and GABAergic neurons as well as the subtypes for each of these two broad classes remains largely unknown. Here we demonstrate with conditional genetic approaches in mice that SMAD4, a major mediator of BMP and TGFβ signaling, is required early in cerebellar development for maintaining the RL and generating subsets of RL-derived glutamatergic neurons, namely neurons of the deep cerebellar nuclei, unipolar brush cells, and the late cohort of granule cell precursors (GCPs). The early cohort of GCPs, despite being deficient for SMAD4, is still generated. In addition, the numbers of GABAergic neurons are reduced in the mutant and the distribution of Purkinje cells becomes abnormal. These studies demonstrate a temporally and spatially restricted requirement for SMAD4 in generating subtypes of cerebellar neurons.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Fernandes M,Antoine M,Hébert JMdoi
10.1016/j.ydbio.2012.02.017subject
Has Abstractpub_date
2012-05-01 00:00:00pages
82-90issue
1eissn
0012-1606issn
1095-564Xpii
S0012-1606(12)00086-3journal_volume
365pub_type
杂志文章abstract：:In the course of embryogenesis multicellular structures and organs are assembled from constituent cells. One structural component common to many organs is the tube, which consists most simply of a luminal space surrounded by a single layer of epithelial cells. The notochord of ascidian Ciona forms a tube consisting of...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2009.03.015
更新日期：2009-06-15 00:00:00
abstract：:We have cloned a member of the fork head/HNF-3 family of transcription factors from the nematode Caenorhabditis elegans. Within the predicted DNA binding domain, this gene, called Ce-fkh-1, is 75-78% identical to the Drosophila fork head and rat liver HNF-3 alpha, beta, and gamma genes. Ce-fkh-1 mRNA is highly enriche...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1996.0219
更新日期：1996-09-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2007.04.028
更新日期：2007-07-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2011.08.024
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(87)90342-3
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2008.08.016
更新日期：2008-11-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(83)90318-4
更新日期：1983-03-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2008.01.015
更新日期：2008-04-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.ydbio.2011.03.015
更新日期：2011-06-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2009.10.021
更新日期：2010-01-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2008.04.037
更新日期：2008-08-01 00:00:00
abstract：:The current picture of embryonic development in nematodes is essentially shaped by Caenorhabditis elegans and its close relatives. As their pattern of embryogenesis is rather similar, it is often considered to be representative for the taxon Nematoda as a whole. Here we give for the first time a comprehensive descript...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2009.06.009
更新日期：2009-10-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2012.04.006
更新日期：2012-06-15 00:00:00
abstract：:Ca2+-sensitive microelectrodes were used to study changes in cytoplasmic free calcium during progesterone-induced meiotic maturation in Xenopus laevis oocytes. In contrast to previous reports, no changes were detected during the maturation process, although a large activation pulse of Ca2+ was seen when in vitro matur...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(85)90475-0
更新日期：1985-06-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2010.06.028
更新日期：2010-09-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1996.8491
更新日期：1997-03-01 00:00:00
abstract：:Cell proliferation, growth and survival are three different basic processes which converge at determining a fundamental property -the size of an organism. Scalloped (Sd) is the first characterised transcriptional partner to Yorkie (Yki), the downstream effector of the Hippo pathway which is a highly potential and evol...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2017.10.016
更新日期：2017-12-15 00:00:00
abstract：:Gastrulation is the first major morphogenetic movement in development and requires dynamic regulation of cell adhesion and the cytoskeleton. Caenorhabditis elegans gastrulation begins with the migration of the two endodermal precursors, Ea and Ep, from the surface of the embryo into the interior. Ea/Ep migration provi...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2010.05.507
更新日期：2010-08-15 00:00:00
abstract：:The pattern of innervation in 13 chicken hindlimb muscles was studied at various stages of development in order to examine the mechanisms which regulate its formation. The pattern of innervation was visualized by examining the distribution of fiber types within each muscle. It was found that the fiber type which a myo...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(83)90080-5
更新日期：1983-05-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章,评审
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更新日期：2017-08-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2012.02.037
更新日期：2012-05-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2012.09.002
更新日期：2012-12-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1998.8887
更新日期：1998-05-15 00:00:00
abstract：:Mutations impairing the GTPase activity of G protein Galpha subunits can result in activated Galpha subunits that affect signal transduction and cellular responses and, in some cases, promote tumor formation. An analogous mutation in the Dictyostelium Galpha4 subunit gene (Q200L substitution) was constructed and found...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1999.9474
更新日期：1999-11-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.2001.0363
更新日期：2001-09-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1998.8854
更新日期：1998-04-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2006.09.021
更新日期：2007-02-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章,评审
doi：10.1016/0012-1606(92)90173-e
更新日期：1992-06-01 00:00:00
abstract：:Mouse embryo limb cells carrying either the brachypodism (bpH/bpH) mutation or its wild-type (+/+) allele were tested for their ability to accumulate cyclic AMP in response to prostaglandin E2 (PGE2) between Embryonic Days E12 and E14. Mutant cells exhibited a precocious increase in cyclic AMP. In the absence of PGE2 ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(90)90372-p
更新日期：1990-12-01 00:00:00
