Abstract：
:Chordin is the prototype of a group of cysteine-rich domain-containing proteins that bind and modulate signaling of various TGFbeta-like ligands. Chordin-like 1 and 2 (CHL1 and 2) are two members of this group that have been described in human, mouse, and chick. However, in vivo roles for CHL1 and 2 in early development are unknown due to lack of loss-of-function analysis. Here we identify and characterize zebrafish, Danio rerio, CHL (Chl). The chl gene is on a region of chromosome 21 syntenic with the area of murine chromosome 7 bearing the CHL2 gene. Inability to identify a separate zebrafish gene corresponding to the mammalian CHL1 gene suggests that Chl may serve roles in zebrafish distributed between CHL1 and CHL2 in other species. Chl is a maternal factor that is also zygotically expressed later in development and has spatiotemporal expression patterns that differ from but overlap those of zebrafish chordin (Chd), suggesting differences but also possible overlap in developmental roles of the two proteins. Chl, like Chd, dorsalizes embryos upon overexpression and is cleaved by BMP1, which antagonizes this activity. Loss-of-function experiments demonstrate that Chl serves as a BMP antagonist with functions that overlap and are redundant with those of Chd in forming the dorsoventral axis.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Branam AM,Hoffman GG,Pelegri F,Greenspan DSdoi
10.1016/j.ydbio.2010.03.001subject
Has Abstractpub_date
2010-05-15 00:00:00pages
444-58issue
2eissn
0012-1606issn
1095-564Xpii
S0012-1606(10)00148-Xjournal_volume
341pub_type
杂志文章abstract：:Sulfs are secreted sulfatases that catalyse removal of sulfate from Heparan Sulfate Proteoglycans (HSPGs) in the extracellular space. These enzymes are well known to regulate a number of crucial signalling pathways during development. In this study, we report that DSulfatase-1 (DSulf1), the unique Drosophila Sulf prot...
journal_title：Developmental biology
pub_type： 杂志文章
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journal_title：Developmental biology
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journal_title：Developmental biology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Developmental biology
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pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(84)90006-x
更新日期：1984-05-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章,评审
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1997-08-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2004.03.023
更新日期：2004-07-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1999.9204
更新日期：1999-04-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2006-12-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.ydbio.2012.07.018
更新日期：2012-10-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2005.09.005
更新日期：2005-11-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
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journal_title：Developmental biology
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journal_title：Developmental biology
pub_type： 杂志文章
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journal_title：Developmental biology
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更新日期：2000-12-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
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journal_title：Developmental biology
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更新日期：2007-02-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2011-01-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.2002.0717
更新日期：2002-08-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章,评审
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更新日期：2004-01-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(84)90237-9
更新日期：1984-12-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1983-11-01 00:00:00
abstract：:During endochondral ossification, the differentiation of proliferating into hypertrophic chondrocytes is a key step determining the pace of bone formation and the future length of the skeletal elements. A variety of transcription factors are expressed at the onset of hypertrophy coordinating the expression of differen...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2019.09.012
更新日期：2020-01-01 00:00:00
