Dynamin-mediated endocytosis is required for tube closure, cell intercalation, and biased apical expansion during epithelial tubulogenesis in the Drosophila ovary.

abstract：:Elk3/Net/Sap2 (here referred to as Elk3) is an Ets ternary complex transcriptional repressor known for its involvement in angiogenesis during embryonic development. Although Elk3 is expressed in various tissues, additional roles for the protein outside of vasculature development have yet to be reported. Here, we chara...

journal_title：Developmental biology

authors： Rogers CD,Phillips JL,Bronner ME

更新日期：2013-02-15 00:00:00

abstract：:We have investigated the sequential changes of acetylcholine receptor (AChR) distribution on identified Xenopus laevis muscle cells in culture before and after innervation. AChRs on muscle cells were stained with tetramethylrhodamine-conjugated alpha-bungarotoxin and the distribution of AChR clusters was examined on a...

journal_title：Developmental biology

authors： Kuromi H,Kidokoro Y

更新日期：1984-05-01 00:00:00

abstract：:Paracrine signaling mediated by FGF-10 and the FGF-R2IIIb receptor is required for formation of the lung. To determine the temporal requirements for FGF signaling during pulmonary morphogenesis, Sprouty-4 (Spry-4), an intracellular FGF receptor antagonist, was expressed in epithelial cells of the fetal lung under cont...

journal_title：Developmental biology

authors： Perl AK,Hokuto I,Impagnatiello MA,Christofori G,Whitsett JA

更新日期：2003-06-01 00:00:00

abstract：:During early development, GATA factors have been shown to be important for key events of coronary vasculogenesis, including formation of the epicardium. Myocardial GATA factors are required for coronary vascular (CV) formation; however, the role of epicardial localized GATAs in this process has not been addressed. The...

journal_title：Developmental biology

authors： Kolander KD,Holtz ML,Cossette SM,Duncan SA,Misra RP

更新日期：2014-02-01 00:00:00

abstract：:The development of germ cells is a highly ordered process that begins during fetal growth and is completed in the adult. Epigenetic modifications that occur in germ cells are important for germ cell function and for post-fertilization embryonic development. We have previously shown that male germ cells in the adult mo...

journal_title：Developmental biology

authors： Oakes CC,La Salle S,Smiraglia DJ,Robaire B,Trasler JM

更新日期：2007-07-15 00:00:00

abstract：UNLABELLED:Notch signaling plays an acknowledged role in bile-duct development, but its involvement in cholangiocyte-fate determination remains incompletely understood. We investigated the effects of early Notch2 deletion in Notch2(fl/fl)/Alfp-Cre(tg/-) ("Notch2-cKO") and Notch2(fl/fl)/Alfp-Cre(-/-) ("control") mice. F...

journal_title：Developmental biology

authors： Falix FA,Weeda VB,Labruyere WT,Poncy A,de Waart DR,Hakvoort TB,Lemaigre F,Gaemers IC,Aronson DC,Lamers WH

更新日期：2014-12-15 00:00:00

abstract：:Similar amounts of expression of a luciferase reporter gene that is driven by the SV40 early promoter are detected in G2 of 1-cell mouse embryo following injection of the male pronucleus in either early or mid/late S. No luciferase activity is observed when the male pronucleus is injected in early S and the embryos an...

journal_title：Developmental biology

authors： Ram PT,Schultz RM

更新日期：1993-04-01 00:00:00

abstract：:Previous experiments in which vitamin A has been administered to developing or regenerating limbs have shown that different limb axes are affected. In regenerating axolotl limbs, serial reduplications in the proximodistal axis are produced. In the developing chick limb bud, mirror-imaged reduplications in the anteropo...

journal_title：Developmental biology

authors： Maden M

更新日期：1983-08-01 00:00:00

abstract：:In adult vertebrates, fibroblast growth factor (FGF) synergizes with many hematopoietic cytokines to stimulate the proliferation of hematopoietic progenitors. In vertebrate development, the FGF signaling pathway is important in the formation of some derivatives of ventroposterior mesoderm. However, the function of FGF...

journal_title：Developmental biology

authors： Xu RH,Ault KT,Kim J,Park MJ,Hwang YS,Peng Y,Sredni D,Kung Hf

更新日期：1999-04-15 00:00:00

abstract：:All metazoan genomes encode multiple RAS GTPase activating proteins (RasGAPs) that negatively regulate the conserved RAS/MAPK signaling pathway. In mammals, several RasGAPs exhibit tumor suppressor activity by preventing excess RAS signal transduction. We have identified gap-3 as the to date missing Caenorhabditiseleg...

journal_title：Developmental biology

authors： Stetak A,Gutierrez P,Hajnal A

更新日期：2008-11-15 00:00:00

abstract：:Specification of the primordial germ cells (PGCs) is essential for sexually reproducing animals. Although the mechanisms of PGC specification are diverse between organisms, the RNA binding protein Nanos is consistently required in the germ line in all species tested. How Nanos is selectively expressed in the germ line...

journal_title：Developmental biology

authors： Oulhen N,Swartz SZ,Wang L,Wikramanayake A,Wessel GM

更新日期：2019-08-01 00:00:00

abstract：:Completion of cytokinesis, abscission, has been studied little despite the intensive studies of the onset and contractile mechanism of the earlier phases of division. It has been well documented that microtubule (MT) disruption before furrow stimulation prevents furrowing, while MT disruption after furrow stimulation ...

journal_title：Developmental biology

authors： Larkin K,Danilchik MV

更新日期：1999-10-01 00:00:00

abstract：:In the Drosophila ventral nerve cord, the three pairs of Capability neuropeptide-expressing Va neurons are exclusively found in the second, third and fourth abdominal segments (A2-A4). To address the underlying mechanisms behind such segment-specific cell specification, we followed the developmental specification of t...

journal_title：Developmental biology

authors： Suska A,Miguel-Aliaga I,Thor S

更新日期：2011-05-01 00:00:00

abstract：:Myf5 is a key myogenic determination factor, specifically present at sites of myogenesis. Surprisingly, during mouse development, this gene is also transcribed in restricted areas of the central nervous system, although the Myf5 protein is not detectable. We have investigated the regulation of Myf5 expression in the c...

journal_title：Developmental biology

authors： Daubas P,Crist CG,Bajard L,Relaix F,Pecnard E,Rocancourt D,Buckingham M

更新日期：2009-03-01 00:00:00

abstract：:The anterior-posterior gut pattern is formed from three broad domains: fore-, mid-, and hindgut that have distinct functional, morphological, and molecular boundaries. The stomach demarcates the posterior boundary of the foregut. Avian stomachs are composed of two chambers: the anterior chamber (proventriculus) and th...

journal_title：Developmental biology

authors： Nielsen C,Murtaugh LC,Chyung JC,Lassar A,Roberts DJ

更新日期：2001-03-01 00:00:00

abstract：:Biologists have long recognized that dramatic bending of a cell sheet may be driven by even modest shrinking of the apical sides of cells. Cell shape changes and tissue movements like these are at the core of many of the morphogenetic movements that shape animal form during development, driving processes such as gastr...

journal_title：Developmental biology

authors： Sawyer JM,Harrell JR,Shemer G,Sullivan-Brown J,Roh-Johnson M,Goldstein B

更新日期：2010-05-01 00:00:00

abstract：:Anuran amphibian embryos (Xenopus laevis and Rana dybowskii) are sensitive to novel gravitational fields. Under simulated weightlessness, (i) the location of the first horizontal cleavage furrow was shifted toward the vegetal pole at the eight-cell stage; (ii) the position of the blastocoel was more centered, and the ...

journal_title：Developmental biology

authors： Neff AW,Yokota H,Chung HM,Wakahara M,Malacinski GM

更新日期：1993-01-01 00:00:00

abstract：:To understand mechanisms of sex determination, it is important to know the lineage relationships of cells comprising the gonads. For example, in mice, the Y-linked gene Sry triggers differentiation of Sertoli cells from a cell population originating in the coelomic epithelium overlying the nascent gonad that also give...

journal_title：Developmental biology

authors： Sekido R,Lovell-Badge R

更新日期：2007-02-01 00:00:00

abstract：:The relationship between cellular position and growth control has been studied in cultures of dissociated fragments of mouse limb bud cells. Using cells derived from various positions along the anterior-posterior axis of the limb bud we have developed culture conditions that optimize growth of positionally isolated ce...

journal_title：Developmental biology

authors： Shi C,Muneoka K

更新日期：1992-05-01 00:00:00

abstract：:Characterization of the molecular pathways controlling differentiation and proliferation in mammalian hair follicles is central to our understanding of the regulation of normal hair growth, the basis of hereditary hair loss diseases, and the origin of follicle-based tumors. We demonstrate that the proto-oncogene Wnt3,...

journal_title：Developmental biology

authors： Millar SE,Willert K,Salinas PC,Roelink H,Nusse R,Sussman DJ,Barsh GS

更新日期：1999-03-01 00:00:00

abstract：:The aim of this study was to evaluate the role segmentation plays in the determination of neuronal identity in the hindbrain. We focused on two specific sets of hindbrain neurons, namely, the vestibulospinal and vestibulo-ocular neurons, which comprise distinct groups that can be identified and distinguished by virtue...

journal_title：Developmental biology

authors： Díaz C,Puelles L,Marín F,Glover JC

更新日期：1998-10-01 00:00:00

abstract：:The role of the wound epithelium in amphibian limb regeneration is not understood. We showed previously that monoclonal antibody (mAb) WE3 stains the wound epithelium but not skin epidermis, suggesting that the WE3 antigen may be a marker for, or be important in, the function of the wound epithelium. In the present st...

journal_title：Developmental biology

authors： Goldhamer DJ,Tomlinson BL,Tassava RA

更新日期：1989-10-01 00:00:00

abstract：:The surface of eggs of the ascidian Halocynthia roretzi, observed with SEM, is essentially smooth until immediately before cell division when numerous microvilli appear and remain during cytokinesis. As the dividing blastomeres become closely adherent, however, the microvilli disappear and the eggs recover their smoot...

journal_title：Developmental biology

authors： Satoh N,Deno T

更新日期：1984-04-01 00:00:00

abstract：:Fetal human hepatocytes were isolated by collagenase digestion of liver fragments and cultured either alone or mixed with rat liver epithelial cells. Whereas they did not survive more than 2-3 weeks and showed rapid morphologic and functional alterations in conventional culture, fetal hepatocytes survived and retained...

journal_title：Developmental biology

authors： Guguen-Guillouzo C,Clement B,Lescoat G,Glaise D,Guillouzo A

更新日期：1984-09-01 00:00:00

abstract：:Complex intrinsic and extrinsic mechanisms determine neural cell fate during development of the nervous system. Using Id4 deficient mice, we show that Id4 is required for normal development of the central nervous system (CNS), timing neural differentiation in the developing forebrain. In the absence of Id4, the ventri...

journal_title：Developmental biology

authors： Bedford L,Walker R,Kondo T,van Crüchten I,King ER,Sablitzky F

更新日期：2005-04-15 00:00:00

abstract：:The mammalian prostate arises from the urogenital sinus and few factors have been identified to be important in the early stages of prostate development. In this study we show that the transcription factor Sox9 is expressed in the epithelia of all mouse prostatic lobes from the initial stages of their development. We ...

journal_title：Developmental biology

authors： Thomsen MK,Butler CM,Shen MM,Swain A

更新日期：2008-04-15 00:00:00

abstract：:Nontransformed cultures of vascular smooth muscle cells proliferate until they form a confluent sheet of cells. Subsequently, the cells become reorganized to form multicellular nodules that are loosely attached to the substrate. The formation of nodules is facilitated by the addition of medium conditioned by nodular c...

journal_title：Developmental biology

authors： Brennan MJ,Millis AJ,Mann D,Fritz KE

更新日期：1983-06-01 00:00:00

abstract：:Rho GTPases control signal transduction pathways that link cell surface receptors to a variety of intracellular responses. They are best known as regulators of the actin cytoskeleton, but in addition they control cell polarity, gene expression, microtubule dynamics and vesicular trafficking. Through these diverse func...

journal_title：Developmental biology

authors： Raftopoulou M,Hall A

更新日期：2004-01-01 00:00:00

abstract：:Neonatal mouse hearts fully regenerate after ventricular resection similar to adult zebrafish. We established cryoinjury models to determine if different types and varying degrees of severity in cardiac injuries trigger different responses in neonatal mouse hearts. In contrast to ventricular resection, neonatal mouse ...

journal_title：Developmental biology

authors： Darehzereshki A,Rubin N,Gamba L,Kim J,Fraser J,Huang Y,Billings J,Mohammadzadeh R,Wood J,Warburton D,Kaartinen V,Lien CL

更新日期：2015-03-01 00:00:00

abstract：:The plasticity of nerve cells expressing the neuropeptide FMRFamide was examined in adult hydra. Using a whole-mount technique with indirect immunofluorescence, the spatial pattern of neurons showing FMRFamide-like immunoreactivity (FLI) was visualized. These neurons were located in the tentacles, hypostome, and pedun...

journal_title：Developmental biology

authors： Koizumi O,Bode HR

更新日期：1986-08-01 00:00:00