Segment-specific generation of Drosophila Capability neuropeptide neurons by multi-faceted Hox cues.


:In the Drosophila ventral nerve cord, the three pairs of Capability neuropeptide-expressing Va neurons are exclusively found in the second, third and fourth abdominal segments (A2-A4). To address the underlying mechanisms behind such segment-specific cell specification, we followed the developmental specification of these neurons. We find that Va neurons are initially generated in all ventral nerve cord segments and progress along a common differentiation path. However, their terminal differentiation only manifests itself in A2-A4, due to two distinct mechanisms: segment-specific programmed cell death (PCD) in posterior segments, and differentiation to an alternative identity in segments anterior to A2. Genetic analyses reveal that the Hox homeotic genes are involved in the segment-specific appearance of Va neurons. In posterior segments, the Hox gene Abdominal-B exerts a pro-apoptotic role on Va neurons, which involves the function of several RHG genes. Strikingly, this role of Abd-B is completely opposite to its role in the segment-specific apoptosis of other classes of neuropeptide neurons, the dMP2 and MP1 neurons, where Abd-B acts in an anti-apoptotic manner. In segments A2-A4 we find that abdominal A is important for the terminal differentiation of Va cell fate. In the A1 segment, Ultrabithorax acts to specify an alternate Va neuron fate. In contrast, in thoracic segments, Antennapedia suppresses the Va cell fate. Thus, Hox genes act in a multi-faceted manner to control the segment-specific appearance of the Va neuropeptide neurons in the ventral nerve cord.


Dev Biol


Developmental biology


Suska A,Miguel-Aliaga I,Thor S




Has Abstract


2011-05-01 00:00:00














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    journal_title:Developmental biology

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: García-Calero E,Fernández-Garre P,Martínez S,Puelles L

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Danos MC,Yost HJ

    更新日期:1996-07-10 00:00:00

  • A dual function of the Notch gene in Drosophila sensillum development.

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    journal_title:Developmental biology

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    authors: Hartenstein V,Posakony JW

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  • Bifurcation dynamics in lineage-commitment in bipotent progenitor cells.

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Huang S,Guo YP,May G,Enver T

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  • Translational regulation of the novel haploid-specific transcripts for the c-abl proto-oncogene and a member of the 70 kDa heat-shock protein gene family in the male germ line.

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    pub_type: 杂志文章


    authors: Zakeri ZF,Ponzetto C,Wolgemuth DJ

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  • Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish.

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    pub_type: 杂志文章


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    更新日期:1995-10-01 00:00:00

  • Expression of the Distalless-B gene in Ciona is regulated by a pan-ectodermal enhancer module.

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    journal_title:Developmental biology

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    journal_title:Developmental biology

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    pub_type: 杂志文章


    authors: Reese DE,Zavaljevski M,Streiff NL,Bader D

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    journal_title:Developmental biology

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    authors: Scully NF,Shur BD

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    journal_title:Developmental biology

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Swalla BJ,Upholt WB,Solursh M

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    journal_title:Developmental biology

    pub_type: 杂志文章


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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Huynh DP,Nechiporuk T,Pulst SM

    更新日期:1994-02-01 00:00:00

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Wells DE,Gutierrez L,Xu Z,Krylov V,Macha J,Blankenburg KP,Hitchens M,Bellot LJ,Spivey M,Stemple DL,Kowis A,Ye Y,Pasternak S,Owen J,Tran T,Slavikova R,Tumova L,Tlapakova T,Seifertova E,Scherer SE,Sater AK

    更新日期:2011-06-01 00:00:00