The regulatory mechanisms that underlie inappropriate transcription of the myogenic determination gene Myf5 in the central nervous system.

Abstract:

:Myf5 is a key myogenic determination factor, specifically present at sites of myogenesis. Surprisingly, during mouse development, this gene is also transcribed in restricted areas of the central nervous system, although the Myf5 protein is not detectable. We have investigated the regulation of Myf5 expression in the central nervous system. Using both in ovo electroporation in the chick embryo and transgenesis in the mouse, we show that regulatory sequences that direct neuronal Myf5 transcription are present in a distal element located between -55 and -54.3 Kb from the Myf5 gene. An Oct6/Tst1 binding site is required for embryonic brain expression, and in the Oct6 mutant mouse embryo, Myf5 transcripts are no longer detectable in the brain. The Wnt-beta catenin signalling pathway is also implicated. Finally we show that post-transcriptional regulation of Myf5 gene expression involves miRNA repression acting through the Myf5-3'UTR.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Daubas P,Crist CG,Bajard L,Relaix F,Pecnard E,Rocancourt D,Buckingham M

doi

10.1016/j.ydbio.2008.11.031

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

71-82

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(08)01382-1

journal_volume

327

pub_type

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