The regulatory mechanisms that underlie inappropriate transcription of the myogenic determination gene Myf5 in the central nervous system.

abstract：:To form a gonad, germ cells (GCs) and somatic gonadal precursor cells (SGPs) must migrate to the correct location in the developing embryo and establish the cell-cell interactions necessary to create proper gonad architecture. During gonad morphogenesis, SGPs send out cellular extensions to ensheath the individual GCs...

journal_title：Developmental biology

authors： Jemc JC,Milutinovich AB,Weyers JJ,Takeda Y,Van Doren M

更新日期：2012-07-15 00:00:00

abstract：:Two main processes are involved in driving ventral mesendoderm internalization in the Xenopus gastrula. First, vegetal rotation, an active movement of the vegetal cell mass, initiates gastrulation by rolling the peripheral blastocoel floor against the blastocoel roof. In this way, the leading edge of the internalized ...

journal_title：Developmental biology

authors： Ibrahim H,Winklbauer R

更新日期：2001-12-01 00:00:00

abstract：:In ascidian embryos, the earliest transcription from the zygotic genome begins between the 8-cell and 16-cell stages. Gata.a, a maternally expressed Gata transcription factor, activates target genes specifically in the animal hemisphere, whereas the complex of β-catenin and Tcf7 antagonizes the activity of Gata.a and ...

journal_title：Developmental biology

authors： Imai KS,Kobayashi K,Kari W,Rothbächer U,Ookubo N,Oda-Ishii I,Satou Y

更新日期：2020-02-15 00:00:00

abstract：:We have investigated the ability of growing dictyate oocytes and early preimplantation embryos of the mouse to process extrachromosomal DNA molecules with free ends by intranuclearly microinjecting DNA fragments containing a region of homology of various extent at either the 5' or 3' terminus. Homologous recombination...

journal_title：Developmental biology

authors： Fiorenza MT,Bevilacqua A,Bevilacqua S,Mangia F

更新日期：2001-05-01 00:00:00

abstract：:In this paper I sought to determine how the expression of differentiated traits of chick retinal pigmented epithelial (RPE) cells in vitro can be modulated by varying both the biochemical and the spatial complexity, and the mechanical properties, of the growth substratum. I have used glass derivatized with proteins of...

journal_title：Developmental biology

authors： Opas M

更新日期：1989-02-01 00:00:00

abstract：:DNA amplification for two major DNA puffs (II/2B and II/9A) of the fungus fly Sciara coprophila increases steeply from 17 to 19 days after hatching (18 degrees C), resulting in almost 20-fold more DNA at these loci in mature larval salivary glands than in adult tissues. At 19 days after hatching when gene amplificatio...

journal_title：Developmental biology

authors： Wu N,Liang C,DiBartolomeis SM,Smith HS,Gerbi SA

更新日期：1993-11-01 00:00:00

abstract：:Antibodies to nonerythroid alpha spectrin (p 230) were used to study the distribution of this polypeptide in mouse germ cells, zygote, and early embryonic cells. In the primordial germ cells, fetal oocytes, and spermatogonia, spectrin was found predominantly in the form of a narrow condensed subplasmalemmal band, as i...

journal_title：Developmental biology

authors： Damjanov I,Damjanov A,Lehto VP,Virtanen I

更新日期：1986-03-01 00:00:00

abstract：:Continuous communication between cells is necessary for development of any multicellular organism and depends on the recognition of secreted signals. A wide range of molecules including proteins, peptides, amino acids, nucleic acids, steroids and polylketides are used as intercellular signals in plants and animals. Th...

journal_title：Developmental biology

authors： Loomis WF

更新日期：2014-07-01 00:00:00

abstract：:A follicular cDNA library from Bombyx mori (576 clones) was screened to obtain a representative sample of chorion sequences differentially expressed during the early period of choriogenesis. Ten selected sequences were characterized by Northern analysis and by dot blots of stage-specific RNA. Five of these sequences (...

journal_title：Developmental biology

authors： Eickbush TH,Rodakis GC,Lecanidou R,Kafatos FC

更新日期：1985-12-01 00:00:00

abstract：:We examined the structure, expression, and possible functions of a nanos homologue during gametogenesis and blastogenesis in the colonial ascidian Botryllus primigenus. An approximately 1.3-kb-long cDNA was cloned; it was termed BpNos since the deduced amino acid sequence (288 aa) contained 2 Nanos-like CCHC zinc fing...

journal_title：Developmental biology

authors： Sunanaga T,Satoh M,Kawamura K

更新日期：2008-12-01 00:00:00

abstract：:Insulin-producing beta-cells are present as single cells or in small clusters distributed throughout the pancreas of the Xenopus laevis tadpole. During metamorphic climax when the exocrine pancreas dedifferentiates to progenitor cells, the beta-cells undergo two changes. Insulin mRNA is down regulated at the beginning...

journal_title：Developmental biology

authors： Mukhi S,Horb ME,Brown DD

更新日期：2009-04-15 00:00:00

abstract：:In tetrapods, the anteroposterior (AP) patterning of the limb is under the control of the antagonistic activities of the secreted factor Sonic hedgehog (Shh) and Gli3R, the truncated repressor form of the transcription factor Gli3. In this report, we show that Msx1 and Msx2 are targets and downstream effectors of Gli3...

journal_title：Developmental biology

authors： Lallemand Y,Bensoussan V,Cloment CS,Robert B

更新日期：2009-07-15 00:00:00

abstract：:Notch signaling inhibits hair cell differentiation, based on studies on mice deficient in Notch signaling-related genes and its downstream genes. However, the precise mechanisms of this inhibition are unknown because it is difficult to control the timing and duration of the suppression of Notch signaling. Here, we dev...

journal_title：Developmental biology

authors： Takebayashi S,Yamamoto N,Yabe D,Fukuda H,Kojima K,Ito J,Honjo T

更新日期：2007-07-01 00:00:00

abstract：:The extracorporeal vasculature of the colonial ascidian Botryllus schlosseri plays a key role in several biological processes: transporting blood, angiogenesis, regeneration, self-nonself recognition, and parabiosis. The vasculature also interconnects all individuals in a colony and is composed of a single layer of ec...

journal_title：Developmental biology

authors： Rodriguez D,Nourizadeh S,De Tomaso AW

更新日期：2019-04-15 00:00:00

abstract：UNLABELLED:Notch signaling plays an acknowledged role in bile-duct development, but its involvement in cholangiocyte-fate determination remains incompletely understood. We investigated the effects of early Notch2 deletion in Notch2(fl/fl)/Alfp-Cre(tg/-) ("Notch2-cKO") and Notch2(fl/fl)/Alfp-Cre(-/-) ("control") mice. F...

journal_title：Developmental biology

authors： Falix FA,Weeda VB,Labruyere WT,Poncy A,de Waart DR,Hakvoort TB,Lemaigre F,Gaemers IC,Aronson DC,Lamers WH

更新日期：2014-12-15 00:00:00

abstract：:To examine the role of postsynaptic activity in regulating the rate of neuromuscular synapse elimination, contractile activity of neonatal rabbit soleus muscles was decreased by chronic superfusion of alpha-bungarotoxin (alpha-BGT) over their surfaces. Superfusion was begun at 6 days postnatal and continued for a vari...

journal_title：Developmental biology

authors： Callaway EM,Van Essen DC

更新日期：1989-02-01 00:00:00

abstract：:A new monoclonal antibody, specific to an epitope in the carboxyl terminus of the Drosophila collagen IV molecule (basement membrane collagen) was identified. The distributions of collagen IV, laminin, and an additional extracellular molecule, the 2G2 antigen (2G2-Ag), were followed immunocytochemically during early w...

journal_title：Developmental biology

authors： Murray MA,Fessler LI,Palka J

更新日期：1995-03-01 00:00:00

abstract：:Developing vertebrate limbs are often utilized as a model for studying pattern formation and morphogenetic cell death. Herein, we report that conditional deletion of Rac1, a member of the Rho family of proteins, in mouse limb bud mesenchyme led to skeletal deformities in the autopod and soft tissue syndactyly, with th...

journal_title：Developmental biology

authors： Suzuki D,Yamada A,Amano T,Yasuhara R,Kimura A,Sakahara M,Tsumaki N,Takeda S,Tamura M,Nakamura M,Wada N,Nohno T,Shiroishi T,Aiba A,Kamijo R

更新日期：2009-11-15 00:00:00

abstract：:In vertebrates, nodal-related genes are crucial for specifying mesendodermal cell fates. Six nodal-related genes have been identified in Xenopus, but only one, nodal, has been identified in the mouse. The Xenopus nodal-related gene 3 (Xnr3), however, lacks the mesoderm-inducing activity of the other five nodal-related...

journal_title：Developmental biology

authors： Haramoto Y,Tanegashima K,Onuma Y,Takahashi S,Sekizaki H,Asashima M

更新日期：2004-01-01 00:00:00

abstract：:Members of the fibroblast growth factor (FGF) family of peptide growth factors are widely expressed in the germ layer derivatives during gastrulation and early organogenesis of the mouse. We have investigated the effect of administering recombinant FGF-4 in the late-primitive streak stage embryo to test if the pattern...

journal_title：Developmental biology

authors： Davidson BP,Cheng L,Kinder SJ,Tam PP

更新日期：2000-05-01 00:00:00

abstract：:During vesicular transport between the endoplasmic reticulum and the Golgi, members of the TMED/p24 protein family form hetero-oligomeric complexes that facilitate protein-cargo recognition as well as vesicle budding. In addition, they regulate each other's level of expression. Despite analyses of TMED/p24 protein dis...

journal_title：Developmental biology

authors： Jerome-Majewska LA,Achkar T,Luo L,Lupu F,Lacy E

更新日期：2010-05-01 00:00:00

abstract：:Mesodermal cell migration during amphibian gastrulation is dependent on cellular interactions with fibronectin. One mechanism whereby cells bind fibronectin is through alpha v-containing integrin heterodimers. In order to investigate the role of alpha v in amphibian gastrulation, we have cloned the Pleurodeles homolog...

journal_title：Developmental biology

authors： Alfandari D,Whittaker CA,DeSimone DW,Darribère T

更新日期：1995-08-01 00:00:00

abstract：:Vitelline coats (VCs) of Phallusia mammillata were isolated and purified following homogenization of live eggs in order to investigate the molecular basis of sperm-egg recognition. Clean VCs were partly solubilized by sonication in H2O and the soluble fraction (SFVC), derived from the outer surface of VCs, was used fo...

journal_title：Developmental biology

authors： Litscher E,Honegger TG

更新日期：1991-12-01 00:00:00

abstract：:Trophoblast cells are characterized by an invasive behavior into the surrounding uterine tissue. In rodents, an early peri-/endovascular type of invasion exerted by trophoblast giant cells can be distinguished from a late interstitial type carried out by glycogen trophoblast cells. Analysis of the molecular mechanisms...

journal_title：Developmental biology

authors： Hemberger M,Hughes M,Cross JC

更新日期：2004-07-15 00:00:00

abstract：:The formation of the spinal cord during early embryonic development in vertebrate embryos is a continuous process that begins at gastrulation and continues through to the completion of somitogenesis. Despite the conserved usage of patterning mechanisms and gene regulatory networks that act to generate specific spinal ...

journal_title：Developmental biology

authors： Steventon B,Martinez Arias A

更新日期：2017-12-01 00:00:00

abstract：:After induction and specification in the ectoderm, at the border of the neural plate, the neural crest (NC) population leaves its original territory through a delamination process. Soon afterwards, the NC cells migrate throughout the embryo and colonize a myriad of tissues and organs where they settle and differentiat...

journal_title：Developmental biology

authors： Theveneau E,Mayor R

更新日期：2012-06-01 00:00:00

abstract：:Oct-4 is the earliest expressed gene known to encode a transcription factor which is developmentally regulated during mammalian embryogenesis. In order to understand the role of Oct-4 in early murine embryogenesis, we carried out an analysis of the temporal and spatial pattern of protein expression. We report the pres...

journal_title：Developmental biology

authors： Palmieri SL,Peter W,Hess H,Schöler HR

更新日期：1994-11-01 00:00:00

abstract：:To investigate the lineage relationships of neurons and astroglial cells early in central nervous system development, we have analyzed the progeny of neural plate cells in an amphibian embryo (Pleurodeles waltl). A fluorescent tracer, lysinated rhodamine-dextran, was iontophoretically injected into individual precurso...

journal_title：Developmental biology

authors： Soula C,Foulquier F,Duprat AM,Cochard P

更新日期：1993-09-01 00:00:00

abstract：:Paracrine signaling mediated by FGF-10 and the FGF-R2IIIb receptor is required for formation of the lung. To determine the temporal requirements for FGF signaling during pulmonary morphogenesis, Sprouty-4 (Spry-4), an intracellular FGF receptor antagonist, was expressed in epithelial cells of the fetal lung under cont...

journal_title：Developmental biology

authors： Perl AK,Hokuto I,Impagnatiello MA,Christofori G,Whitsett JA

更新日期：2003-06-01 00:00:00

abstract：:The Drosophila larval central brain contains about 10,000 differentiated neurons and 200 scattered neural progenitors (neuroblasts), which can be further subdivided into ~95 type I neuroblasts and eight type II neuroblasts per brain lobe. Only type II neuroblasts generate self-renewing intermediate neural progenitors ...

journal_title：Developmental biology

authors： Carney TD,Miller MR,Robinson KJ,Bayraktar OA,Osterhout JA,Doe CQ

更新日期：2012-01-01 00:00:00