The regulatory mechanisms that underlie inappropriate transcription of the myogenic determination gene Myf5 in the central nervous system.


:Myf5 is a key myogenic determination factor, specifically present at sites of myogenesis. Surprisingly, during mouse development, this gene is also transcribed in restricted areas of the central nervous system, although the Myf5 protein is not detectable. We have investigated the regulation of Myf5 expression in the central nervous system. Using both in ovo electroporation in the chick embryo and transgenesis in the mouse, we show that regulatory sequences that direct neuronal Myf5 transcription are present in a distal element located between -55 and -54.3 Kb from the Myf5 gene. An Oct6/Tst1 binding site is required for embryonic brain expression, and in the Oct6 mutant mouse embryo, Myf5 transcripts are no longer detectable in the brain. The Wnt-beta catenin signalling pathway is also implicated. Finally we show that post-transcriptional regulation of Myf5 gene expression involves miRNA repression acting through the Myf5-3'UTR.


Dev Biol


Developmental biology


Daubas P,Crist CG,Bajard L,Relaix F,Pecnard E,Rocancourt D,Buckingham M




Has Abstract


2009-03-01 00:00:00














  • Timing and rates of synthesis of early histone mRNA in the embryo of Strongylocentrotus purpuratus.

    abstract::The level of early histone mRNA in Strongylocentrotus purpuratus changes abruptly at 6 hr of development, increasing an average of 10-fold by 9-10.5 hr and then decreasing over 2-fold by 13.5-15 hr. These changes occur when the late embryonic mRNA is still a very minor component of histone gene transcription. The exac...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Weinberg ES,Hendricks MB,Hemminki K,Kuwabara PE,Farrelly LA

    更新日期:1983-07-01 00:00:00

  • Fibronectin, mesoderm migration, and gastrulation in Xenopus.

    abstract::The role of fibronectin in mesoderm cell migration and and the importance of mesoderm migration for gastrulation in Xenopus are examined. To allow for migration, a stable interface must exist between migrating mesoderm cells and the cells of the substrate layer, the blastocoel roof. We show that maintenance of this in...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Winklbauer R,Keller RE

    更新日期:1996-08-01 00:00:00

  • SpGCF1, a sea urchin embryo DNA-binding protein, exists as five nested variants encoded by a single mRNA.

    abstract::Several Strongylocentrotus purpuratus gene cis-regulatory regions contain asymmetric C4 sequences which are core elements of target sites for a specific DNA-protein interaction. Blastula stage nuclear extract contains five proteins which specifically bind to these target sites, resulting in a characteristic pattern of...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Zeller RW,Coffman JA,Harrington MG,Britten RJ,Davidson EH

    更新日期:1995-06-01 00:00:00

  • Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart.

    abstract::A subset of macrophages that reside in adult tissues originate from the fetal yolk sac, while others derive from circulating monocytes. These ontologically different macrophage subsets have distinct roles in tissue injury responses, with the embryonic population overall having beneficial activity in cardiac repair. He...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Stevens SM,von Gise A,VanDusen N,Zhou B,Pu WT

    更新日期:2016-05-15 00:00:00

  • Reduced cAMP secretion in Dictyostelium discoideum mutant HB3.

    abstract::Extracellular cAMP induces the intracellular synthesis and subsequent secretion of cAMP in Dictyostelium discoideum (relay). cAMP relay was strongly diminished in mutant HB3 which shows abnormal development by making very small fruiting bodies. Extracellular cAMP binds to receptors on the surface of mutant cells and i...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Kesbeke F,Van Haastert PJ

    更新日期:1988-12-01 00:00:00

  • The insulator protein Suppressor of Hairy wing is required for proper ring canal development during oogenesis in Drosophila.

    abstract::Chromatin insulators orchestrate gene transcription during embryo development and cell differentiation by stabilizing interactions between distant genomic sites. Mutations in genes encoding insulator proteins are generally lethal, making in vivo functional analyses of insulator proteins difficult. In Drosophila, howev...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Hsu SJ,Plata MP,Ernest B,Asgarifar S,Labrador M

    更新日期:2015-07-01 00:00:00

  • GRDN-1/Girdin regulates dendrite morphogenesis and cilium position in two specialized sensory neuron types in C. elegans.

    abstract::Primary cilia are located at the dendritic tips of sensory neurons and house the molecular machinery necessary for detection and transduction of sensory stimuli. The mechanisms that coordinate dendrite extension with cilium position during sensory neuron development are not well understood. Here, we show that GRDN-1, ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Nechipurenko I,Lavrentyeva S,Sengupta P

    更新日期:2021-01-16 00:00:00

  • The MEK inhibitor, U0126, alters fertilization-induced [Ca2+]i oscillation parameters and secretion: differential effects associated with in vivo and in vitro meiotic maturation.

    abstract::Although mitogen-activated protein kinase (MAPK) is a well-known cell cycle regulator, emerging studies have also implicated its activity in the regulation of intracellular calcium concentration ([Ca2+](i)) and secretion. Those studies raise the hypothesis that MAPK activity during oocyte maturation and early fertiliz...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Matson S,Ducibella T

    更新日期:2007-06-15 00:00:00

  • Stage-specific increase in cell surface galactosyltransferase activity during spermatogenesis in mice bearing t alleles.

    abstract::Mouse sperm surface galactosyltransferase (GalTase) mediates fertilization by binding to its appropriate glycoconjugate substrate in the egg zona pellucida. GalTase is present throughout all stages of spermatogenesis, during which time it redistributes within the plasma membrane from a uniform, diffuse distribution on...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Scully NF,Shur BD

    更新日期:1988-01-01 00:00:00

  • A dual function of the Notch gene in Drosophila sensillum development.

    abstract::We have investigated the function of the neurogenic gene Notch (N) during development of the adult sensilla of Drosophila. Heat pulses were applied to flies carrying the temperature-sensitive Notch allele Nts1 at different larval and pupal stages. We can show that the reduction of Notch+ function during a short interv...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Hartenstein V,Posakony JW

    更新日期:1990-11-01 00:00:00

  • Mesendoderm extension and mantle closure in Xenopus laevis gastrulation: combined roles for integrin alpha(5)beta(1), fibronectin, and tissue geometry.

    abstract::We describe mesendoderm morphogenesis during gastrulation in the frog Xenopus laevis and investigate the mechanics of these movements with tissue explants. When a dorsal marginal zone explant is plated onto fibronectin, the mesendoderm moves away from the dorsal axial tissues as an intact sheet. Mesendodermal cells wi...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Davidson LA,Hoffstrom BG,Keller R,DeSimone DW

    更新日期:2002-02-15 00:00:00

  • Identification and characterization of alternatively spliced fibronectin mRNAs expressed in early Xenopus embryos.

    abstract::Sequence analysis of cDNA clones encoding fibronectin (FN) from Xenopus laevis reveals extensive amino acid identities with other vertebrate FNs, including the presence of the Arg-Gly-Asp (RGD) cell attachment site in type III-10 and of a second, cell-binding site (EILDV) in the alternative spliced V region of the pro...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: DeSimone DW,Norton PA,Hynes RO

    更新日期:1992-02-01 00:00:00

  • Genetic analysis of melanophore development in zebrafish embryos.

    abstract::Vertebrate pigment cells are derived from neural crest, a tissue that also forms most of the peripheral nervous system and a variety of ectomesenchymal cell types. Formation of pigment cells from multipotential neural crest cells involves a number of common developmental processes. Pigment cells must be specified; the...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Kelsh RN,Schmid B,Eisen JS

    更新日期:2000-09-15 00:00:00

  • Yolk proteins of Caenorhabditis elegans.

    abstract::A group of proteins judged on several criteria to be yolk proteins have been isolated from a homogenate of the nematode Caenorhabditis elegans. Comparison of partial proteolysis fragments indicates that the two bands of a 170,000-dalton doublet (yp170) are closely related; bands observed at 115,000 daltons (yp115) and...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Sharrock WJ

    更新日期:1983-03-01 00:00:00

  • Genomics and expression profiles of the Hedgehog and Notch signaling pathways in sea urchin development.

    abstract::The Hedgehog (Hh) and Notch signal transduction pathways control a variety of developmental processes including cell fate choice, differentiation, proliferation, patterning and boundary formation. Because many components of these pathways are conserved, it was predicted and confirmed that pathway components are largel...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Walton KD,Croce JC,Glenn TD,Wu SY,McClay DR

    更新日期:2006-12-01 00:00:00

  • Nemo phosphorylates Even-skipped and promotes Eve-mediated repression of odd-skipped in even parasegments during Drosophila embryogenesis.

    abstract::Drosophila nemo (nmo) and other Nemo-like kinase family members (Nlks) are well-established key regulators of numerous conserved signaling pathways, such as Wg and BMP. nmo mutants display pleiotropic defects at different developmental stages, including the embryo. In this study we describe a detailed characterization...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Braid LR,Lee W,Uetrecht AC,Swarup S,Papaianni G,Heiler A,Verheyen EM

    更新日期:2010-07-01 00:00:00

  • Genetic patterning in the adult capitate antenna of the beetle Tribolium castaneum.

    abstract::Antenna structure varies widely among insects, in contrast to the well-conserved structure of legs. The adult capitate antenna of the red flour beetle, Tribolium castaneum, is composed of eleven articles, organized into four distinct morphological regions (scape, pedicel, funicle and club). Here, we report the use of ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Angelini DR,Kikuchi M,Jockusch EL

    更新日期:2009-03-01 00:00:00

  • Reverse engineering liver buds through self-driven condensation and organization towards medical application.

    abstract::The self-organizing tissue-based approach coupled with induced pluripotent stem (iPS) cell technology is evolving as a promising field for designing organoids in culture and is expected to achieve valuable practical outcomes in regenerative medicine and drug development. Organoids show properties of functional organs ...

    journal_title:Developmental biology

    pub_type: 杂志文章,评审


    authors: Shinozawa T,Yoshikawa HY,Takebe T

    更新日期:2016-12-15 00:00:00

  • Making sense of Dlx1 antisense RNA.

    abstract::Long non-coding RNAs (lncRNAs) have been recently recognized as a major class of regulators in mammalian systems. LncRNAs function by diverse and heterogeneous mechanisms in gene regulation, and are key contributors to development, neurological disorders, and cancer. This emerging importance of lncRNAs, along with rec...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Kraus P,Sivakamasundari V,Lim SL,Xing X,Lipovich L,Lufkin T

    更新日期:2013-04-15 00:00:00

  • Scalloped a member of the Hippo tumor suppressor pathway controls mushroom body size in Drosophila brain by non-canonical regulation of neuroblast proliferation.

    abstract::Cell proliferation, growth and survival are three different basic processes which converge at determining a fundamental property -the size of an organism. Scalloped (Sd) is the first characterised transcriptional partner to Yorkie (Yki), the downstream effector of the Hippo pathway which is a highly potential and evol...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Rohith BN,Shyamala BV

    更新日期:2017-12-15 00:00:00

  • Perturbation of cranial neural crest migration by the HNK-1 antibody.

    abstract::The HNK-1 antibody recognizes a carbohydrate moiety that is shared by a family of cell adhesion molecules and is also present on the surface of migrating neural crest cells. Here, the effects of the HNK-1 antibody on neural crest cells were examined in vitro and in vivo. When the HNK-1 antibody was added to neural tub...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Bronner-Fraser M

    更新日期:1987-10-01 00:00:00

  • Homeotic genes autonomously specify the anteroposterior subdivision of the Drosophila dorsal vessel into aorta and heart.

    abstract::The embryonic dorsal vessel in Drosophila possesses anteroposterior polarity and is subdivided into two chamber-like portions, the aorta in the anterior and the heart in the posterior. The heart portion features a wider bore as compared with the aorta and develops inflow valves (ostia) that allow the pumping of hemoly...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Lo PC,Skeath JB,Gajewski K,Schulz RA,Frasch M

    更新日期:2002-11-15 00:00:00

  • bves: A novel gene expressed during coronary blood vessel development.

    abstract::We have used a subtractive method to clone novel messages enriched in the heart. Here we show that one such message, bves (blood vessel/epicardial substance) is a novel protein that is highly conserved between chicken and mouse. The bves message is detected at high levels in early chick hearts. Using anti-Bves antibod...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Reese DE,Zavaljevski M,Streiff NL,Bader D

    更新日期:1999-05-01 00:00:00

  • Multiple roles of Notch signaling in cochlear development.

    abstract::Notch signaling inhibits hair cell differentiation, based on studies on mice deficient in Notch signaling-related genes and its downstream genes. However, the precise mechanisms of this inhibition are unknown because it is difficult to control the timing and duration of the suppression of Notch signaling. Here, we dev...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Takebayashi S,Yamamoto N,Yabe D,Fukuda H,Kojima K,Ito J,Honjo T

    更新日期:2007-07-01 00:00:00

  • Purkinje cell lineage and the topographic organization of the cerebellar cortex: a view from X inactivation mosaics.

    abstract::We utilized a strain of mice, derived from a radiation mutagenesis experiment and carrying an activity-attenuated allele of the X-linked enzyme glucose-6-phosphate dehydrogenase (G6PD), to analyze the development of the cell lineage leading to cerebellar Purkinje neurons. Due to random X inactivation during early embr...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Baader SL,Schilling ML,Rosengarten B,Pretsch W,Teutsch HF,Oberdick J,Schilling K

    更新日期:1996-03-15 00:00:00

  • Bifurcation dynamics in lineage-commitment in bipotent progenitor cells.

    abstract::Lineage specification of multipotent progenitor cells is governed by a balance of lineage-affiliated transcription factors, such as GATA1 and PU.1, which regulate the choice between erythroid and myelomonocytic fates. But how ratios of lineage-determining transcription factors stabilize progenitor cells and resolve th...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Huang S,Guo YP,May G,Enver T

    更新日期:2007-05-15 00:00:00

  • Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in mice.

    abstract::Runx2-Cbfa1, a Runt transcription factor, plays important roles during skeletal development. It is required for differentiation and function of osteoblasts. In its absence, chondrocyte hypertrophy is severely impaired and there is no vascularization of cartilage templates during skeletal development. These tissue-spec...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Wang W,Wang YG,Reginato AM,Glotzer DJ,Fukai N,Plotkina S,Karsenty G,Olsen BR

    更新日期:2004-06-15 00:00:00

  • Expression and interaction of muscle-related genes in the lamprey imply the evolutionary scenario for vertebrate skeletal muscle, in association with the acquisition of the neck and fins.

    abstract::Gnathostomes (jawed vertebrates) possess skeletal muscles with unique functional and developmental features that are absent from cyclostomes-i.e., lamprey and hagfish. These gnathostome-specific traits include the epaxial and hypaxial division of myotomes, paired fin/limb muscles, shoulder girdle muscles, and the musc...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Kusakabe R,Kuraku S,Kuratani S

    更新日期:2011-02-01 00:00:00

  • Pristionchus pacificus vulva formation: polarized division, cell migration, cell fusion, and evolution of invagination.

    abstract::Tube formation is a widespread process during organogenesis. Specific cellular behaviors participate in the invagination of epithelial monolayers that form tubes. However, little is known about the evolutionary mechanisms of cell assembly into tubes during development. In Caenorhabditis elegans, the detailed step-to-s...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Kolotuev I,Podbilewicz B

    更新日期:2004-02-15 00:00:00

  • WIND1 induces dynamic metabolomic reprogramming during regeneration in Brassica napus.

    abstract::Plants often display a high competence for regeneration under stress conditions. Signals produced in response to various types of stress serve as critical triggers for de novo organogenesis, but the identity of these signaling molecules underlying cellular reprogramming are largely unknown. We previously identified an...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Iwase A,Mita K,Favero DS,Mitsuda N,Sasaki R,Kobayshi M,Takebayashi Y,Kojima M,Kusano M,Oikawa A,Sakakibara H,Saito K,Imamura J,Sugimoto K

    更新日期:2018-10-01 00:00:00