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Tracheal development in the Drosophila brain is constrained by glial cells.

Abstract：

:The Drosophila brain is tracheated by the cerebral trachea, a branch of the first segmental trachea of the embryo. During larval stages the cerebral trachea splits into several main (primary) branches that grow around the neuropile, forming a perineuropilar tracheal plexus (PNP) at the neuropile surface. Five primary tracheal branches whose spatial relationship to brain compartments is relatively invariant can be distinguished, although the exact trajectories and branching pattern of the brain tracheae are surprisingly variable. Immunohistochemical and electron microscopic studies demonstrate that all brain tracheae grow in direct contact with the glial cell processes that surround the neuropile. To investigate the effect of glia on tracheal development, embryos and larvae lacking glial cells as a result of a genetic mutation or a directed ablation were analyzed. In these animals, the tracheal branching pattern was highly abnormal. In particular, the number of secondary branches entering the central neuropile was increased. Wild-type larvae possess only two central tracheae, typically associated with the mushroom body and the antennocerebral tract. In larvae lacking glial cells, six to ten tracheal branches penetrate the neuropile in a variable pattern. This finding indicates that glia-derived signals constrained tracheal growth in the Drosophila brain and restrict the number of branches entering the neuropile.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Pereanu W,Spindler S,Cruz L,Hartenstein V

doi

10.1016/j.ydbio.2006.09.022

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

169-80

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(06)01223-1

journal_volume

302

pub_type

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