Endothelium is required for the promotion of interrenal morphogenetic movement during early zebrafish development.


:The adrenal cortex has a complex vasculature that is essential for growth, tissue maintenance, and access of secreted steroids to the bloodstream. However, the interaction between vasculature and adrenal cortex during early organogenesis remains largely unclear. In this study, we focused on the zebrafish counterpart of adrenal cortex, interrenal tissue, to explore the possible role of endothelium in the development of steroidogenic tissues. The ontogeny of interrenal tissue was found to be tightly associated with the endothelial cells (ECs) that constitute the axial vessels. The early interrenal primordia emerge as two clusters of cells that migrate centrally and converge at the midline, whereas the central convergence was abrogated in the avascular cloche (clo) mutant. Neither loss of blood circulation nor perturbations of vessel assembly could account for the interrenal convergence defect, implying a role of endothelial signaling prior to the formation of axial blood vessels. Moreover, as the absence of trunk endothelium in clo mutant was rescued by the forced expression of SCL, the interrenal fusion defect could be alleviated. We thus conclude that endothelial signaling is involved in the morphogenetic movement of early interrenal tissue.


Dev Biol


Developmental biology


Liu YW,Guo L




Has Abstract


2006-09-01 00:00:00














  • Involvement of K(Ca) channels and stretch-activated channels in calcium influx, triggering membrane fusion of chick embryonic myoblasts.

    abstract::Calcium influx is known to be prerequisite for membrane fusion of myoblasts. However, little is known about the channels that are responsible for the entry of calcium into the cells. Here we show that K(Ca) channels and stretch-activated channels are involved in the calcium influx. Upon analysis of single-channel reco...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Shin KS,Park JY,Ha DB,Chung CH,Kang MS

    更新日期:1996-04-10 00:00:00

  • The relationship between rhombomeres and vestibular neuron populations as assessed in quail-chicken chimeras.

    abstract::The aim of this study was to evaluate the role segmentation plays in the determination of neuronal identity in the hindbrain. We focused on two specific sets of hindbrain neurons, namely, the vestibulospinal and vestibulo-ocular neurons, which comprise distinct groups that can be identified and distinguished by virtue...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Díaz C,Puelles L,Marín F,Glover JC

    更新日期:1998-10-01 00:00:00

  • XsFRP5 modulates endodermal organogenesis in Xenopus laevis.

    abstract::Canonical Wnt signalling is known to be involved in the regulation of differentiation and proliferation in the context of endodermal organogenesis. Wnt mediated beta-catenin activation is understood to be modulated by secreted Frizzled-related proteins, such as XsFRP5, which is dynamically expressed in the prospective...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Damianitsch K,Melchert J,Pieler T

    更新日期:2009-05-15 00:00:00

  • Aberrant Wnt signalling and cellular over-proliferation in a novel mouse model of Meckel-Gruber syndrome.

    abstract::Meckel-Gruber syndrome (MKS) is an embryonic lethal ciliopathy resulting from mutations in genes encoding proteins localising to the primary cilium. Mutations in the basal body protein MKS1 account for 7% of cases of MKS. The condition affects the development of multiple organs, including brain, kidney and skeleton. H...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Wheway G,Abdelhamed Z,Natarajan S,Toomes C,Inglehearn C,Johnson CA

    更新日期:2013-05-01 00:00:00

  • Neuron-muscle contact changes presynaptic resting calcium set-point.

    abstract::The role of retrograde signaling between target cells and their presynaptic partners during early cell-cell interactions was examined in cell culture. Using time-lapse video microscopy and fura-2 calcium analysis, we followed contacts between presynaptic neurites of Helisoma motoneurons and muscle fibers dissociated f...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Zoran MJ,Funte LR,Kater SB,Haydon PG

    更新日期:1993-07-01 00:00:00

  • Requirement for ADAMTS-1 in extracellular matrix remodeling during ovarian folliculogenesis and lymphangiogenesis.

    abstract::Murine ovarian folliculogenesis commences after birth involving oocyte growth, somatic cell differentiation and structural remodeling of follicle stromal boundaries. The extracellular metalloproteinase ADAMTS-1 has activity against proteoglycans and collagen and is produced by the granulosa cells of ovarian follicles....

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Brown HM,Dunning KR,Robker RL,Pritchard M,Russell DL

    更新日期:2006-12-15 00:00:00

  • Tenascin in the developing chick visual system: distribution and potential role as a modulator of retinal axon growth.

    abstract::The distribution of the extracellular matrix protein tenascin was studied in the developing chick visual system to determine its possible regulatory role in retinotectal development. Little tenascin was present in the retinal optic fiber layer, and the optic nerve and tract, but was abundant in the stratum opticum of ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Perez RG,Halfter W

    更新日期:1993-03-01 00:00:00

  • CLIP-50 immunolocalization during mouse spermiogenesis suggests a role in shaping the sperm nucleus.

    abstract::The spermatid nucleus and cytoplasm undergo dramatic morphological modifications during spermatid differentiation into mature sperm. Some of the external force causing this nuclear shaping is generated by a microtubular structure termed the manchette, which attaches to the perinuclear ring of the spermatid. Here, we r...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Tarsounas M,Pearlman RE,Moens PB

    更新日期:2001-08-15 00:00:00

  • Prorenin receptor is critical for nephron progenitors.

    abstract::Deficient nephrogenesis is the major factor contributing to renal hypoplasia defined as abnormally small kidneys. Nephron induction during kidney development is driven by reciprocal interactions between progenitor cells of the cap mesenchyme (CM) and the ureteric bud (UB). The prorenin receptor (PRR) is a receptor for...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Song R,Preston G,Kidd L,Bushnell D,Sims-Lucas S,Bates CM,Yosypiv IV

    更新日期:2016-01-15 00:00:00

  • Near complete loss of retinal ganglion cells in the math5/brn3b double knockout elicits severe reductions of other cell types during retinal development.

    abstract::Retinal ganglion cells (RGCs) are the first cell type to differentiate during retinal histogenesis. It has been postulated that specified RGCs subsequently influence the number and fate of the remaining progenitors to produce the rest of the retinal cell types. However, several genetic knockout models have argued agai...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Moshiri A,Gonzalez E,Tagawa K,Maeda H,Wang M,Frishman LJ,Wang SW

    更新日期:2008-04-15 00:00:00

  • Polyubiquitin RNA characteristics and conditional induction in sea urchin embryos.

    abstract::A cDNA of the sea urchin Strongylocentrotus purpuratus was identified as encoding polyubiquitin and used to detect a single gene with transcripts containing multiple ubiquitin coding units. Polyubiquitin transcripts exist as a 3.2-kb RNA in polyribosomes and as three higher molecular weight RNAs in purified nuclei. Th...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Nemer M,Rondinelli E,Infante D,Infante AA

    更新日期:1991-06-01 00:00:00

  • Transient apical polarization of Gliotactin and Coracle is required for parallel alignment of wing hairs in Drosophila.

    abstract::In Drosophila, wing hairs are aligned in a distally oriented, parallel array. The frizzled pathway determines proximal-distal cell polarity in the wing; however, in frizzled pathway mutants, wing hairs remain parallel. How wing hairs align has not been determined. We have demonstrated a novel role for the septate junc...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Venema DR,Zeev-Ben-Mordehai T,Auld VJ

    更新日期:2004-11-15 00:00:00

  • Bifurcation dynamics in lineage-commitment in bipotent progenitor cells.

    abstract::Lineage specification of multipotent progenitor cells is governed by a balance of lineage-affiliated transcription factors, such as GATA1 and PU.1, which regulate the choice between erythroid and myelomonocytic fates. But how ratios of lineage-determining transcription factors stabilize progenitor cells and resolve th...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Huang S,Guo YP,May G,Enver T

    更新日期:2007-05-15 00:00:00

  • Post-implantation mouse conceptuses produce paracrine signals that regulate the uterine endometrium undergoing decidualization.

    abstract::The uterus undergoes a series of dramatic changes in response to an implanting conceptus that, in some mammalian species, includes differentiation of the endometrial stroma into decidual tissue. This process, called decidualization, can be induced artificially in rodents indicating that the conceptus may not be essent...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Bany BM,Cross JC

    更新日期:2006-06-15 00:00:00

  • The Sm proteins regulate germ cell specification during early C. elegans embryogenesis.

    abstract::Sm and Sm-like proteins are core components of the splicesome but have other functions distinct from pre-mRNA processing. Here, we show that Sm proteins also regulate germ cell specification during early C. elegans embryogenesis. SmE and SmG were required to maintain transcriptional quiescence in embryonic germ cell p...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Barbee SA,Evans TC

    更新日期:2006-03-01 00:00:00

  • Modulation of N-cadherin junctions and their role as epicenters of differentiation-specific actin regulation in the developing lens.

    abstract::Extensive elongation of lens fiber cells is a central feature of lens morphogenesis. Our study investigates the role of N-cadherin junctions in this process in vivo. We investigate both the molecular players involved in N-cadherin junctional maturation and the subsequent function of these junctions as epicenters for t...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Leonard M,Zhang L,Zhai N,Cader A,Chan Y,Nowak RB,Fowler VM,Menko AS

    更新日期:2011-01-15 00:00:00

  • Unmasking mRNA in clam oocytes: role of phosphorylation of a 3' UTR masking element-binding protein at fertilization.

    abstract::During meiotic maturation or after fertilization of invertebrate and vertebrate oocytes, many of the quiescent stored mRNAs are recruited into polysomes. In the clam, Spisula solidissima, such masked messages include the abundant mRNAs encoding cyclin A and the small subunit of ribonucleotide reductase. We have previo...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Walker J,Dale M,Standart N

    更新日期:1996-01-10 00:00:00

  • Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina.

    abstract::Vertebrate retinal progenitor cells (RPCs) undergo a robust proliferative expansion to produce enough cells for the retina to form appropriately. Vsx2 (formerly Chx10), a homeodomain protein expressed in RPCs, is required for sufficient proliferation to occur. Sonic Hedgehog protein (SHH), secreted by retinal ganglion...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Sigulinsky CL,Green ES,Clark AM,Levine EM

    更新日期:2008-05-15 00:00:00

  • Xenopus Teashirt1 regulates posterior identity in brain and cranial neural crest.

    abstract::We have isolated two related Xenopus homologues of the homeotic zinc finger protein Teashirt1 (Tsh1), XTsh1a and XTsh1b. While Drosophila teashirt specifies trunk identity in the fly, the developmental relevance of vertebrate Tsh homologues is unknown. XTsh1a/b are expressed in prospective trunk CNS throughout early n...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Koebernick K,Kashef J,Pieler T,Wedlich D

    更新日期:2006-10-01 00:00:00

  • Late extraembryonic morphogenesis and its zen(RNAi)-induced failure in the milkweed bug Oncopeltus fasciatus.

    abstract::Many insects undergo katatrepsis, essential reorganization by the extraembryonic membranes that repositions the embryo. Knockdown of the zen gene by RNA interference (RNAi) prevents katatrepsis in the milkweed bug Oncopeltus fasciatus. However, the precise morphogenetic defect has been uncertain, and katatrepsis itsel...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Panfilio KA

    更新日期:2009-09-15 00:00:00

  • Two temporal functions of Glass: Ommatidium patterning and photoreceptor differentiation.

    abstract::Much progress has been made in elucidating the molecular networks required for specifying retinal cells, including photoreceptors, but the downstream mechanisms that maintain identity and regulate differentiation remain poorly understood. Here, we report that the transcription factor Glass has a dual role in establish...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Liang X,Mahato S,Hemmerich C,Zelhof AC

    更新日期:2016-06-01 00:00:00

  • Delayed accumulation of maternal histone mRNA during sea urchin oogenesis.

    abstract::We have used in situ hybridization and RNA blotting analysis to compare the timing of accumulation of poly(A) and alpha-subtype histone mRNA during oogenesis in the sea urchin Strongylocentrotus purpuratus. In situ hybridization with 3H-poly(U) shows that the content of poly(A) in the developing oocyte increases four-...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Angerer LM,DeLeon DV,Angerer RC,Showman RM,Wells DE,RafF RA

    更新日期:1984-02-01 00:00:00

  • MGF (KIT ligand) is a chemokinetic factor for melanoblast migration into hair follicles.

    abstract::Melanoblasts, the precursors of the pigment-producing cells of the skin and hair, are derived from the neural crest and migrate to the skin around 12 days of gestation in the mouse. In adult mice almost all the melanoblasts are confined to the hair follicles except for the epidermal layers of nonhairy skin. The recept...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Jordan SA,Jackson IJ

    更新日期:2000-09-15 00:00:00

  • Studies of the developing chick retina using monoclonal antibody 8A2 that recognizes a novel set of gangliosides.

    abstract::A monoclonal antibody, Mab 8A2, that recognizes a novel set of gangliosides was produced by immunizing a mouse with Embryonic Day 14 chick optic nerve. Immunohistochemical studies of the developing chick retina revealed a complex pattern of Mab 8A2 immunoreactivity. Initially, staining is concentrated in the optic fib...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Drazba J,Pierce M,Lemmon V

    更新日期:1991-05-01 00:00:00

  • Xenopus tropicalis nodal-related gene 3 regulates BMP signaling: an essential role for the pro-region.

    abstract::In vertebrates, nodal-related genes are crucial for specifying mesendodermal cell fates. Six nodal-related genes have been identified in Xenopus, but only one, nodal, has been identified in the mouse. The Xenopus nodal-related gene 3 (Xnr3), however, lacks the mesoderm-inducing activity of the other five nodal-related...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Haramoto Y,Tanegashima K,Onuma Y,Takahashi S,Sekizaki H,Asashima M

    更新日期:2004-01-01 00:00:00

  • Xenopus embryos lacking specific isoforms of the corepressor SMRT develop abnormal heads.

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Malartre M,Short S,Sharpe C

    更新日期:2006-04-15 00:00:00

  • Analyses of oviductal pars recta-induced fertilizability of coelomic eggs in Xenopus laevis.

    abstract::The acquisition of fertilizability in coelomic eggs of Xenopus laevis has been shown to be correlated with the physical, biochemical, and ultrastructural alterations of the egg envelope [coelomic envelope (CE)] induced during the passage of eggs through the pars recta portion of the oviduct. However, no direct evidenc...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Katagiri C,Yoshizaki N,Kotani M,Kubo H

    更新日期:1999-06-15 00:00:00

  • The union of somatic gonad precursors and primordial germ cells during Caenorhabditis elegans embryogenesis.

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Rohrschneider MR,Nance J

    更新日期:2013-07-15 00:00:00

  • Early differentiation of vertebrate spinal neurons in the absence of voltage-dependent Ca2+ and Na+ influx.

    abstract::The development of the action potential and responses to neurotransmitters have been described for a population of embryonic spinal neurons developing in vivo. A comparable pattern is seen for spinal neurons developing in dissociated cell culture. The impulse appears very early in this developmental sequence, and the ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Bixby JL,Spitzer NC

    更新日期:1984-11-01 00:00:00

  • Regulation of ascorbic acid concentration in embryonic chick brain.

    abstract::The relationship between ascorbic acid concentration and cellular transport mechanisms was studied in chicken embryos (Gallus gallus domesticus). Unincubated (Day 0) fertile eggs did not contain detectable levels of ascorbic acid as assayed by high performance liquid chromatography with electrochemical detection. Howe...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Wilson JX

    更新日期:1990-06-01 00:00:00