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Nubp2 is required for cranial neural crest survival in the mouse.

Abstract：

:The N-ethyl-N-nitrosourea (ENU) ←forward genetic screen is a useful tool for the unbiased discovery of novel mechanisms regulating developmental processes. We recovered the dorothy mutation in such a screen designed to recover recessive mutations affecting craniofacial development in the mouse. Dorothy embryos die prenatally and exhibit many striking phenotypes commonly associated with ciliopathies, including a severe midfacial clefting phenotype. We used exome sequencing to discover a missense mutation in nucleotide binding protein 2 (Nubp2) to be causative. This finding was confirmed by a complementation assay with the dorothy allele and an independent Nubp2 null allele (Nubp2null). We demonstrated that Nubp2 is indispensable for embryogenesis. NUBP2 is implicated in both the cytosolic iron/sulfur cluster assembly pathway and negative regulation of ciliogenesis. Conditional ablation of Nubp2 in the neural crest lineage with Wnt1-cre recapitulates the dorothy craniofacial phenotype. Using this model, we found that the proportion of ciliated cells in the craniofacial mesenchyme was unchanged, and that markers of the SHH, FGF, and BMP signaling pathways are unaltered. Finally, we show evidence that the phenotype results from a marked increase in apoptosis within the craniofacial mesenchyme.

journal_name

Dev Biol

journal_title

Developmental biology

authors

DiStasio A,Paulding D,Chaturvedi P,Stottmann RW

doi

10.1016/j.ydbio.2019.10.039

subject

Has Abstract

pub_date

2020-02-15 00:00:00

pages

189-199

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(19)30367-7

journal_volume

458

pub_type

杂志文章

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