Temporal pattern of posterior positional identity in mouse limb buds.

abstract：:The cnidarian "planula" larva shows radial symmetry around a polarized, oral-aboral, body axis and comprises two epithelia cell layers, ectodermal and endodermal. This simple body plan is set up during gastrulation, a process which proceeds by a variety of modes amongst the diverse cnidarian species. In the hydrozoan ...

journal_title：Developmental biology

authors： Kraus Y,Chevalier S,Houliston E

更新日期：2020-12-01 00:00:00

abstract：:Rex1 (Zfp42), GeneID 132625, is a gene whose expression is closely associated with pluripotency/multipotency in both mouse and human embryonic stem cells. To study the function of the murine Rex1 gene in vivo, we have used cre/lox technology to create Rex1(floxed) mice and mice deficient in Rex1 gene function. Rex1(-/...

journal_title：Developmental biology

authors： Rezende NC,Lee MY,Monette S,Mark W,Lu A,Gudas LJ

更新日期：2011-08-15 00:00:00

abstract：:Human MusTRD1alpha1 was isolated as a result of its ability to bind a critical element within the Troponin I slow upstream enhancer (TnIslow USE) and was predicted to be a regulator of slow fiber-specific genes. To test this hypothesis in vivo, we generated transgenic mice expressing hMusTRD1alpha1 in skeletal muscle....

journal_title：Developmental biology

authors： Issa LL,Palmer SJ,Guven KL,Santucci N,Hodgson VR,Popovic K,Joya JE,Hardeman EC

更新日期：2006-05-01 00:00:00

abstract：:In the course of embryogenesis multicellular structures and organs are assembled from constituent cells. One structural component common to many organs is the tube, which consists most simply of a luminal space surrounded by a single layer of epithelial cells. The notochord of ascidian Ciona forms a tube consisting of...

journal_title：Developmental biology

authors： Dong B,Horie T,Denker E,Kusakabe T,Tsuda M,Smith WC,Jiang D

更新日期：2009-06-15 00:00:00

abstract：:Complex intrinsic and extrinsic mechanisms determine neural cell fate during development of the nervous system. Using Id4 deficient mice, we show that Id4 is required for normal development of the central nervous system (CNS), timing neural differentiation in the developing forebrain. In the absence of Id4, the ventri...

journal_title：Developmental biology

authors： Bedford L,Walker R,Kondo T,van Crüchten I,King ER,Sablitzky F

更新日期：2005-04-15 00:00:00

abstract：:In the full grown oocyte of Xenopus laevis, a sodium permeability can be induced by depolarization to positive potential with current injection. Voltage-clamp analysis has shown that depolarization causes a long-lasting modification of the membrane during which voltage-gated sodium channels become functional. In the p...

journal_title：Developmental biology

authors： Baud C

更新日期：1983-10-01 00:00:00

abstract：:Fertilized eggs of the leech Helobdella triserialis undergo a cytoplasmic reorganization which generates domains of nonyolky cytoplasm, called teloplasm, at the animal and vegetal poles. The segregation of teloplasm to one cell of the eight-cell embryo is responsible for a unique developmental fate of that cell, i.e.,...

journal_title：Developmental biology

authors： Astrow SH,Holton B,Weisblat DA

更新日期：1989-10-01 00:00:00

abstract：:Members of the fibroblast growth factor (FGF) family of peptide growth factors are widely expressed in the germ layer derivatives during gastrulation and early organogenesis of the mouse. We have investigated the effect of administering recombinant FGF-4 in the late-primitive streak stage embryo to test if the pattern...

journal_title：Developmental biology

authors： Davidson BP,Cheng L,Kinder SJ,Tam PP

更新日期：2000-05-01 00:00:00

abstract：:Immature, Stage VI oocytes of Xenopus laevis fail to activate (i.e., to propagate a cortical reaction and elevate a fertilization envelope) when pricked or exposed to A23187. We determined the times during maturation when immature oocytes treated with progesterone in vitro developed the capacity to respond to pricking...

journal_title：Developmental biology

authors： Charbonneau M,Grey RD

更新日期：1984-03-01 00:00:00

abstract：:The three fibronectin leucine-rich repeat transmembrane (FLRT) proteins contain 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. XFLRT3, a Nodal/TGFbeta target, regulates cell adhesion and modulates FGF signalling during Xenopus gast...

journal_title：Developmental biology

authors： Maretto S,Müller PS,Aricescu AR,Cho KW,Bikoff EK,Robertson EJ

更新日期：2008-06-01 00:00:00

abstract：:We have cloned a Caenorhabditis elegans homologue of the Drosophila gap gene hunchback (hb) and have designated it hbl-1 (hunchback-like). hbl-1 encodes a predicted 982-amino-acid protein, containing two putative zinc-finger domains similar to those of Drosophila Hunchback. The gene is transcribed embryonically, but u...

journal_title：Developmental biology

authors： Fay DS,Stanley HM,Han M,Wood WB

更新日期：1999-01-15 00:00:00

abstract：:Mouse mammary ductal cells cultured in type I collagen gels give rise to three-dimensional multicellular outgrowths consisting of thin spikes which are often branched, and which may have pointed or blunt ends. The significance of these spikes to normal ductal morphogenesis has been unclear, since identical structures ...

journal_title：Developmental biology

authors： Daniel CW,Berger JJ,Strickland P,Garcia R

更新日期：1984-07-01 00:00:00

abstract：:External genital development begins with formation of paired genital swellings, which develop into the genital tubercle. Proximodistal outgrowth and axial patterning of the genital tubercle are coordinated to give rise to the penis or clitoris. The genital tubercle consists of lateral plate mesoderm, surface ectoderm,...

journal_title：Developmental biology

authors： Perriton CL,Powles N,Chiang C,Maconochie MK,Cohn MJ

更新日期：2002-07-01 00:00:00

abstract：:Mutations in the Bone Morphogenetic Protein (BMP) pathway are associated with a range of defects in skeletal formation. Genetic analysis of BMP signaling requirements is complicated by the presence of three partially redundant BMPs that are required for multiple stages of limb development. We generated an inducible al...

journal_title：Developmental biology

authors： Norrie JL,Lewandowski JP,Bouldin CM,Amarnath S,Li Q,Vokes MS,Ehrlich LIR,Harfe BD,Vokes SA

更新日期：2014-09-15 00:00:00

abstract：:Recently, it has been suggested that a mouse sperm-associated protein with properties similar to the inhibitory guanine nucleotide-binding regulatory protein Gi plays an intermediary role in the zona pellucida-induced acrosome reaction (Endo, Y., Lee, M. A., and Kopf, G. S. 1987. Dev. Biol. 119, 210-216). In the prese...

journal_title：Developmental biology

authors： Endo Y,Lee MA,Kopf GS

更新日期：1988-09-01 00:00:00

abstract：:Pancreatic organogenesis relies on a complex interplay of cell-autonomous and extracellular signals. We demonstrate that the morphogen sonic hedgehog (Shh) is required for pancreatic development in zebrafish. Genetic mutants of Shh and its signaling pathway establish this dependence as specific to endocrine, but not e...

journal_title：Developmental biology

authors： diIorio PJ,Moss JB,Sbrogna JL,Karlstrom RO,Moss LG

更新日期：2002-04-01 00:00:00

abstract：:Temperature sex determining species offer a model for investigating how environmental cues become integrated to the regulation of patterning genes and growth, among bipotential gonads. Manipulation of steroid hormones has revealed the important role of aromatase in the regulation of the estrogen levels involved in tem...

journal_title：Developmental biology

authors： Díaz-Hernández V,Marmolejo-Valencia A,Merchant-Larios H

更新日期：2015-12-01 00:00:00

abstract：:Anuran amphibian embryos (Xenopus laevis and Rana dybowskii) are sensitive to novel gravitational fields. Under simulated weightlessness, (i) the location of the first horizontal cleavage furrow was shifted toward the vegetal pole at the eight-cell stage; (ii) the position of the blastocoel was more centered, and the ...

journal_title：Developmental biology

authors： Neff AW,Yokota H,Chung HM,Wakahara M,Malacinski GM

更新日期：1993-01-01 00:00:00

abstract：:nautilus (nau), one member of the myogenic regulatory family of bHLH-encoding genes, is expressed in a subset of muscle precursors and differentiated fibers in the Drosophila embryo. To elucidate the role of nautilus in myogenesis, we have misexpressed it using the GAL4-targeted system. We find that ectopic expression...

journal_title：Developmental biology

authors： Keller CA,Erickson MS,Abmayr SM

更新日期：1997-01-15 00:00:00

abstract：:The specification of the five individual hormone-secreting cell types in the anterior pituitary requires a series of sequential cell fate decisions. We have immortalized cells at several stages along this pathway of pituitary differentiation. Here, we present analysis of differences in gene expression between an anter...

journal_title：Developmental biology

authors： Holley SJ,Hall SB,Mellon PL

更新日期：2002-04-15 00:00:00

abstract：:The fertilized ascidian egg is thought to be comprised of distinct regions of tissue-specific cytoplasmic determinants. This idea was tested by bisecting fertilized eggs into egg fragments and culturing them until the unoperated controls developed into larvae. Fertilized eggs were bisected using a microsurgical method...

journal_title：Developmental biology

authors： Bates WR

更新日期：1988-09-01 00:00:00

abstract：:The direct flight muscles (DFMs) of Drosophila allow for the fine control of wing position necessary for flight. In DWnt-2 mutant flies, certain DFMs are either missing or fail to attach to the correct epithelial sites. Using a temperature-sensitive allele, we show that DWnt-2 activity is required only during pupation...

journal_title：Developmental biology

authors： Kozopas KM,Nusse R

更新日期：2002-03-15 00:00:00

abstract：:During early heart development the expression pattern of N-cadherin, a calcium-dependent cell adhesion molecule, suggests its involvement in morphoregulation and the stabilization of cardiomyocyte differentiation. N-cadherin's adhesive activity is dependent upon its interaction with the intracellular catenins. An asso...

journal_title：Developmental biology

authors： Linask KK,Knudsen KA,Gui YH

更新日期：1997-05-15 00:00:00

abstract：:During development, cells craft an impressive array of actin-based structures, mediating events as diverse as cytokinesis, apical constriction, and cell migration. One challenge is to determine how cells regulate actin assembly and disassembly to carry out these cell behaviors. During Drosophila oogenesis diverse cell...

journal_title：Developmental biology

authors： Gates J,Nowotarski SH,Yin H,Mahaffey JP,Bridges T,Herrera C,Homem CC,Janody F,Montell DJ,Peifer M

更新日期：2009-09-01 00:00:00

abstract：:The insect head is composed of several segments. During embryonic development, the segments fuse to form a rigid head capsule where obvious segmental boundaries are lacking. Hence, the assignment of regions of the insect head to specific segments is hampered, especially with respect to dorsal (vertex) and lateral (gen...

journal_title：Developmental biology

authors： Posnien N,Bucher G

更新日期：2010-02-01 00:00:00

abstract：:Proper patterning and growth of oral structures including teeth, tongue, and palate rely on epithelial-mesenchymal interactions involving coordinated regulation of signal transduction. Understanding molecular mechanisms underpinning oral-facial development will provide novel insights into the etiology of common congen...

journal_title：Developmental biology

authors： Lin C,Fisher AV,Yin Y,Maruyama T,Veith GM,Dhandha M,Huang GJ,Hsu W,Ma L

更新日期：2011-08-01 00:00:00

abstract：:In a previous study (K.-I. Sato et al., 1999, Dev. Biol. 209, 308-320), we presented evidence that a Src-related protein-tyrosine kinase (PTK), named Xyk, may act upstream of the calcium release in fertilization of the Xenopus egg. In the present study, we examined whether PTK activation of phospholipase Cgamma (PLCga...

journal_title：Developmental biology

authors： Sato K,Tokmakov AA,Iwasaki T,Fukami Y

更新日期：2000-08-15 00:00:00

abstract：:Border Cells in the Drosophila ovaries are a useful genetic model for understanding the molecular events underlying epithelial cell motility. During stage 9 of egg chamber development they detach from neighboring stretched cells and migrate between the nurse cells to reach the oocyte. RNAi screening allowed us to iden...

journal_title：Developmental biology

authors： De Graeve FM,Van de Bor V,Ghiglione C,Cerezo D,Jouandin P,Ueda R,Shashidhara LS,Noselli S

更新日期：2012-08-01 00:00:00

abstract：:Recent studies with amoebae of the Myxomycetes Didymium iridis and Physarum polycephalum reveal that competence to undergo sexual fusion or to differentiate to plasmodia apogamically can be induced by a diffusible factor. Suspension cultures of Didymium amoebae have proven to be a good source of the inducer activity. ...

journal_title：Developmental biology

authors： Nader WF,Shipley GL,Huettermann A,Holt CE

更新日期：1984-06-01 00:00:00

abstract：:The murine cpk mouse develops a rapid-onset polycystic kidney disease (PKD) with many similarities to human PKD. During kidney development, the transcription factor Pax2 is required for the specification and differentiation of the renal epithelium. In humans, Pax2 is also expressed in juvenile cystic kidneys where it ...

journal_title：Developmental biology

authors： Ostrom L,Tang MJ,Gruss P,Dressler GR

更新日期：2000-03-15 00:00:00