Analysis of an inducer of the amoebal-plasmodial transition in the myxomycetes Didymium iridis and Physarum polycephalum.

abstract：:Growth and Differentiation Factor 1 (GDF-1) has been implicated in left-right patterning of the mouse embryo but has no other known function. Here, we demonstrate a genetic interaction between Gdf1 and Nodal during anterior axis development. Gdf1-/-;Nodal+/- mutants displayed several abnormalities that were not presen...

journal_title：Developmental biology

authors： Andersson O,Reissmann E,Jörnvall H,Ibáñez CF

更新日期：2006-05-15 00:00:00

abstract：:Crest-derived glomus cells of the carotid body (CB) are O(2)-sensitive chemoreceptors, which resemble sympathoadrenal (SA) chromaffin cells. In this study, we tested whether perinatal rat glomus cells are sensitive to basic fibroblast growth factor (bFGF) in vitro and whether their sensitivity is regulated by oxygen. ...

journal_title：Developmental biology

authors： Nurse CA,Vollmer C

更新日期：1997-04-15 00:00:00

abstract：:We have characterized the antigen recognized by mab10, a monoclonal antibody that has been shown to modify outgrowth of thalamic and cortical axons in vitro, and investigated the influence of this antibody on axonal growth in the chicken retina in vivo. Immunopurification, peptide sequencing, and biochemical character...

journal_title：Developmental biology

authors： Monnier PP,Beck SG,Bolz J,Henke-Fahle S

更新日期：2001-01-01 00:00:00

abstract：:During heart formation, the heart grows and undergoes dramatic morphogenesis to achieve efficient embryonic function. Both in fish and amniotes, much of the growth occurring after initial heart tube formation arises from second heart field (SHF)-derived progenitor cell addition to the arterial pole, allowing chamber f...

journal_title：Developmental biology

authors： Kula-Alwar D,Marber MS,Hughes SM,Hinits Y

更新日期：2021-02-01 00:00:00

abstract：:Although a large superfamily of G-protein-coupled receptors serves multiple functions, little is known about their functional activation during ontogeny. To examine the functional activation of the mu-opioid receptor (MOR) and the delta-opioid receptor (DOR) during development, sections of mouse embryos and fetuses fr...

journal_title：Developmental biology

authors： Nitsche JF,Pintar JE

更新日期：2003-01-01 00:00:00

abstract：:Plant growth and development are driven by extended phases of irreversible cell expansion generating cells that increase in volume from 10- to 100-fold. Some specialized cell types define cortical sites that reinitiate polarized growth and generate branched cell morphology. This structural specialization of individual...

journal_title：Developmental biology

authors： Li J,Kim T,Szymanski DB

更新日期：2019-07-01 00:00:00

abstract：:Smad4 is defined as the common-mediator Smad (co-Smad) required for transducing signals for all TGF-beta superfamily members. This paper describes two Smad4s in Xenopus: XSmad4alpha, which is probably the Xenopus orthologue of human Smad4, and a distinct family member, XSmad4beta, which differs primarily at the extrem...

journal_title：Developmental biology

authors： Howell M,Itoh F,Pierreux CE,Valgeirsdottir S,Itoh S,ten Dijke P,Hill CS

更新日期：1999-10-15 00:00:00

abstract：:The prostate undergoes branching morphogenesis dependent on paracrine interactions between the prostatic epithelium and the urogenital mesenchyme. To identify cell-surface molecules that function in this process, monoclonal antibodies raised against epithelial cell-surface antigens were screened for antigen expression...

journal_title：Developmental biology

authors： Marker PC,Stephan JP,Lee J,Bald L,Mather JP,Cunha GR

更新日期：2001-05-01 00:00:00

abstract：:The cellular mechanisms underlying the amazing ability of sea cucumbers to regenerate their autotomized intestines have been widely described by us and others. However, the signaling pathways that control these mechanisms are unknown. Previous studies have shown that Wnt homologs are upregulated during early intestina...

journal_title：Developmental biology

authors： Bello SA,Torres-Gutiérrez V,Rodríguez-Flores EJ,Toledo-Román EJ,Rodríguez N,Díaz-Díaz LM,Vázquez-Figueroa LD,Cuesta JM,Grillo-Alvarado V,Amador A,Reyes-Rivera J,García-Arrarás JE

更新日期：2020-02-01 00:00:00

abstract：:Trypsin-like activity is secreted from eggs of many species at fertilization, and this activity is believed to be critical for the block to polyspermy. Here we show that a cortical granule serine protease of sea urchins is the major and perhaps only protease family member important for fertilization. Zymography assays...

journal_title：Developmental biology

authors： Haley SA,Wessel GM

更新日期：1999-07-01 00:00:00

abstract：:The mature heart valves and septa are derived from the cardiac cushions which initially form as local outgrowths of mesenchymal cells within the outflow tract and atrioventricular regions. Endocardial cells respond to signals from the overlying myocardium and undergo an epithelial-to-mesenchymal transformation to inva...

journal_title：Developmental biology

authors： Kim RY,Robertson EJ,Solloway MJ

更新日期：2001-07-15 00:00:00

abstract：:Early (alpha) histone genes are one of several histone gene families in the sea urchin genome. They are expressed at high levels in blastula-stage embryos and are inactivated by the early gastrula stage. By microinjecting mutant early H2B genes into sea urchin zygotes and monitoring their transcriptional activity in b...

journal_title：Developmental biology

authors： Bell J,Char BR,Maxson R

更新日期：1992-04-01 00:00:00

abstract：:Skeletal muscle fibers express members of the myosin heavy chain (MyHC) gene family in a fiber-type-specific manner. In avian skeletal muscle it is the expression of the slow MyHC isoforms that most clearly distinguishes slow- from fast-contracting fiber types. Two hypotheses have been proposed to explain fiber-type-s...

journal_title：Developmental biology

authors： DiMario JX,Stockdale FE

更新日期：1997-08-01 00:00:00

abstract：:The migration and fate of cranial and vagal neural crest-derived progenitor cells (NCPCs) have been extensively studied; however, much less is known about sacral NCPCs particularly in regard to their distribution in the urogenital system. To construct a spatiotemporal map of NCPC migration pathways into the developing...

journal_title：Developmental biology

authors： Wiese CB,Deal KK,Ireland SJ,Cantrell VA,Southard-Smith EM

更新日期：2017-09-01 00:00:00

abstract：:One rapid response of starfish oocytes to the maturation-inducing hormone, 1-methyladenine (1-MA), is the formation of transient actin-filled spikes on the cell surface. The presence and distribution of G- and F-actin and several actin-associated proteins were examined in cortices isolated from oocytes before, during,...

journal_title：Developmental biology

authors： Otto JJ,Schroeder TE

更新日期：1984-02-01 00:00:00

abstract：:During development of the central nervous system (CNS), commissural axons grow toward the ventral midline. After crossing the floor plate, they abruptly change their trajectory from the circumferential to the longitudinal axis. The contacts between the commissural axons and the floor plate cells are involved in this a...

journal_title：Developmental biology

authors： Okabe N,Shimizu K,Ozaki-Kuroda K,Nakanishi H,Morimoto K,Takeuchi M,Katsumaru H,Murakami F,Takai Y

更新日期：2004-09-15 00:00:00

abstract：:Vascular smooth muscle of the head derives from neural crest, but developmental mechanisms and early transcriptional drivers of the vSMC lineage are not well characterized. We find that in early development, the transcription factor foxc1b is expressed in mesenchymal cells that associate with the vascular endothelium....

journal_title：Developmental biology

authors： Whitesell TR,Chrystal PW,Ryu JR,Munsie N,Grosse A,French CR,Workentine ML,Li R,Zhu LJ,Waskiewicz A,Lehmann OJ,Lawson ND,Childs SJ

更新日期：2019-09-01 00:00:00

abstract：:The task of the visual system is to translate light into neuronal encoded information. This translation of photons into neuronal signals is achieved by photoreceptor neurons (PRs), specialized sensory neurons, located in the eye. Upon perception of light the PRs will send a signal to target neurons, which represent a ...

journal_title：Developmental biology

authors： Sprecher SG,Cardona A,Hartenstein V

更新日期：2011-10-01 00:00:00

abstract：:To determine whether spontaneous release of transmitter from the growth cones of neurons exhibits properties similar to the spontaneous release which occurs from the neurons at the neuromuscular junction, release of transmitter from the growth cones of Xenopus neurons in culture was monitored in salines containing var...

journal_title：Developmental biology

authors： Young SH

更新日期：1986-02-01 00:00:00

abstract：:During epithelial development cells become polarized along their apical-basal axis and some epithelia also exhibit polarity in the plane of the tissue. Mutations in the gene encoding a Drosophila Pak family serine/threonine kinase, dPak, disrupt the follicular epithelium that covers developing egg chambers during ooge...

journal_title：Developmental biology

authors： Conder R,Yu H,Zahedi B,Harden N

更新日期：2007-05-15 00:00:00

abstract：:Normal growth and morphogenesis of the cranial vault reflect a balance between cell proliferation in the sutures and osteogenesis at the margins of the cranial bones. In the clinical condition craniosynostosis, the sutures fuse prematurely as a result of precocious osteogenic differentiation and craniofacial malformat...

journal_title：Developmental biology

authors： Moore R,Ferretti P,Copp A,Thorogood P

更新日期：2002-03-01 00:00:00

abstract：:During development of the vertebrate visual system, retinal ganglion cell (RGC) axons follow a precise path toward their midbrain targets. Although much is known about the cues that direct RGC axons once they have left the optic disc, less is known about the guidance of axons at earlier stages, when RGCs first send ou...

journal_title：Developmental biology

authors： Ohta K,Tannahill D,Yoshida K,Johnson AR,Cook GM,Keynes RJ

更新日期：1999-07-01 00:00:00

abstract：:The vertebrate pituitary gland is a key endocrine control organ that contains six distinct hormone secreting cell types. In this study, we analyzed the role of direct cell-to-cell Delta-Notch signaling in zebrafish anterior pituitary cell type specification. We demonstrate that initial formation of the anterior pituit...

journal_title：Developmental biology

authors： Dutta S,Dietrich JE,Westerfield M,Varga ZM

更新日期：2008-07-15 00:00:00

abstract：:The mouse Otlx2 gene is a new member of the paired-like family of homeobox genes whose human homologue, RIEG, is involved in Rieger syndrome, an autosomal-dominant disorder. One of the cardinal features of Rieger syndrome is dental hypoplasia, indicating that Otlx2/RIEG activity is essential for normal tooth developme...

journal_title：Developmental biology

authors： Mucchielli ML,Mitsiadis TA,Raffo S,Brunet JF,Proust JP,Goridis C

更新日期：1997-09-15 00:00:00

abstract：:Large steady electrical currents traverse Drosophila follicles in vitro as well as permeabilized eggs. During the period of main follicle growth (stages 9-11), these currents enter the anterior or nurse cell end of the follicles. This inward current acts like a sodium ion influx with some calcium involvement. During t...

journal_title：Developmental biology

authors： Overall R,Jaffe LF

更新日期：1985-03-01 00:00:00

abstract：:Exocytosis of cortical granules in mouse eggs is required to produce the zona pellucida block to polyspermy. In this study, we examined the role of microfilaments and microtubules in the regulation of cortical granule movement toward the cortex during oocyte maturation and anchoring of cortical granules in the cortex....

journal_title：Developmental biology

authors： Connors SA,Kanatsu-Shinohara M,Schultz RM,Kopf GS

更新日期：1998-08-01 00:00:00

abstract：:Ammonium transporter C (AmtC) is one of three transporters in Dictyostelium that have been proposed to regulate entry and exit of ammonia in a cell type dependent manner and to mediate ammonia signaling. Previous work demonstrated that disruption of the amtC gene results in a slugger phenotype in which the cells remai...

journal_title：Developmental biology

authors： Kirsten JH,Xiong Y,Dunbar AJ,Rai M,Singleton CK

更新日期：2005-11-01 00:00:00

abstract：:Chick sensory neurons grow to their correct targets in the hindlimb from the outset during normal development and following various experimental manipulations. This may result not because sensory neurons respond to specific limb-derived cues, but because they interact in some way with motoneurons which are responsive ...

journal_title：Developmental biology

authors： Landmesser L,Honig MG

更新日期：1986-12-01 00:00:00

abstract：:The mechanism by which pluripotent progenitors give rise to distinct classes of mature neurons in vertebrates is not well understood. To address this issue we undertook a genetic screen for mutations which affect the commitment and differentiation of catecholaminergic (CA) [dopaminergic (DA), noradrenergic (NA), and a...

journal_title：Developmental biology

authors： Guo S,Wilson SW,Cooke S,Chitnis AB,Driever W,Rosenthal A

更新日期：1999-04-15 00:00:00

abstract：:The primary lung bud originates from the foregut and develops into the bronchial tree by repetitive branching and outgrowing of the airway. The Sry related HMG box protein Sox2 is expressed in a cyclic manner during initiation and branching morphogenesis of the lung. It is highly expressed in non-branching regions and...

journal_title：Developmental biology

authors： Gontan C,de Munck A,Vermeij M,Grosveld F,Tibboel D,Rottier R

更新日期：2008-05-01 00:00:00