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Conservation as well as divergence in Mcidas function underlies the differentiation of multiciliated cells in vertebrates.

Abstract：

:Multiciliated cells (MCCs) differentiate hundreds of motile cilia that beat to drive fluid movement over various kinds of epithelia. In Xenopus, mice and human, the coiled-coil containing protein Mcidas (Mci) has been shown to be a key transcriptional regulator of MCC differentiation. We have examined Mci function in the zebrafish, another model organism that is widely used to study ciliary biology. We show that zebrafish mci is expressed specifically in the developing MCCs of the kidney tubules, but surprisingly, not in those of the nasal placodes. Mci proteins lack a DNA binding domain and associate with the cell-cycle transcription factors E2f4/5 for regulating MCC-specific gene expression. We found that while the zebrafish Mci protein can complex with the E2f family members, its sequence as well as the requirement and sufficiency for MCC differentiation has diverged significantly from Mci homologues of the tetrapods. We also provide evidence that compared to Gmnc, another related coiled-coil protein that has recently been shown to regulate MCC development upstream of Mci, the Mci protein originated later within the vertebrate lineage. Based on these data, we argue that in contrast to Gmnc, which has a vital role in the genetic circuitry that drives MCC formation, the requirement of Mci, at least in the zebrafish, is not obligatory.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Zhou F,Rayamajhi D,Ravi V,Narasimhan V,Chong YL,Lu H,Venkatesh B,Roy S

doi

10.1016/j.ydbio.2020.07.005

subject

Has Abstract

pub_date

2020-09-15 00:00:00

pages

168-177

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(20)30199-8

journal_volume

465

pub_type

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