Monoclonal antibodies to the murine zona pellucida protein with sperm receptor activity: effects on fertilization and early development.

abstract：:The Drosophila melanogaster ventral nerve cord derives from neural progenitor cells called neuroblasts. Individual neuroblasts have unique gene expression profiles and give rise to distinct clones of neurons and glia. The specification of neuroblast identity provides a cell intrinsic mechanism which ultimately results...

journal_title：Developmental biology

authors： Buescher M,Tio M,Tear G,Overton PM,Brook WJ,Chia W

更新日期：2006-04-15 00:00:00

abstract：:Tyrosinase is the rate-limiting enzyme for the production of melanin pigmentation. In the mouse and other animals, homozygous null mutations in the Tyrosinase gene (Tyr) result in the absence of pigmentation, i.e. albinism. Here we used the CRISPR/Cas9 system to generate mono- and bi-allelic null mutations in the Tyr ...

journal_title：Developmental biology

authors： Yen ST,Zhang M,Deng JM,Usman SJ,Smith CN,Parker-Thornburg J,Swinton PG,Martin JF,Behringer RR

更新日期：2014-09-01 00:00:00

abstract：:Acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF) are present in high levels in most areas of the embryonic rodent brain. To begin to understand the role of these growth factors in brain development, the effects of aFGF and bFGF on dissociated cell cultures prepared from embryonic and ne...

journal_title：Developmental biology

authors： Engele J,Bohn MC

更新日期：1992-08-01 00:00:00

abstract：:The mouse Otlx2 gene is a new member of the paired-like family of homeobox genes whose human homologue, RIEG, is involved in Rieger syndrome, an autosomal-dominant disorder. One of the cardinal features of Rieger syndrome is dental hypoplasia, indicating that Otlx2/RIEG activity is essential for normal tooth developme...

journal_title：Developmental biology

authors： Mucchielli ML,Mitsiadis TA,Raffo S,Brunet JF,Proust JP,Goridis C

更新日期：1997-09-15 00:00:00

abstract：:Patterning of the early neural tube is achieved in part by the inductive signals, which arise from neuroepithelial signaling centers. The zona limitans intrathalamica (ZLI) is a neuroepithelial domain in the alar plate of the diencephalon which separates the prethalamus from the thalamus. The ZLI has recently been con...

journal_title：Developmental biology

authors： Vieira C,Garda AL,Shimamura K,Martinez S

更新日期：2005-08-15 00:00:00

abstract：:Vascular smooth muscle of the head derives from neural crest, but developmental mechanisms and early transcriptional drivers of the vSMC lineage are not well characterized. We find that in early development, the transcription factor foxc1b is expressed in mesenchymal cells that associate with the vascular endothelium....

journal_title：Developmental biology

authors： Whitesell TR,Chrystal PW,Ryu JR,Munsie N,Grosse A,French CR,Workentine ML,Li R,Zhu LJ,Waskiewicz A,Lehmann OJ,Lawson ND,Childs SJ

更新日期：2019-09-01 00:00:00

abstract：:The embryonic vertebrate heart consists of two epithelia: the myocardium and endothelium, separated by the myocardial basement membrane (MBM). The myocardium has been shown to induce endothelial transformation into prevalvular mesenchyme in a temporally and site restricted manner. Previously, we hypothesized that the ...

journal_title：Developmental biology

authors： Mjaatvedt CH,Markwald RR

更新日期：1989-11-01 00:00:00

abstract：:Sm and Sm-like proteins are core components of the splicesome but have other functions distinct from pre-mRNA processing. Here, we show that Sm proteins also regulate germ cell specification during early C. elegans embryogenesis. SmE and SmG were required to maintain transcriptional quiescence in embryonic germ cell p...

journal_title：Developmental biology

authors： Barbee SA,Evans TC

更新日期：2006-03-01 00:00:00

abstract：:Differences are demonstrated in the chondrogenic potential of cells derived from the distal and proximal halves of chick wing buds from as early as stage 23, prior to the appearance of overt cartilage differentiation. In high cell density cultures, cells obtained from the distal portions of stage 23 or 24 limb buds ar...

journal_title：Developmental biology

authors： Swalla BJ,Owens EM,Linsenmayer TF,Solursh M

更新日期：1983-05-01 00:00:00

abstract：:Larvae homozygous for the recessive lethal allele without children(rgl) (woc(rgl)) fail to pupariate. Application of exogenous 20-hydroxyecdysone elicits puparium formation and pupation. Ecdysteroid titer measurements on mutant larvae show an endocrine deficiency in the brain-ring gland complex, which normally synthes...

journal_title：Developmental biology

authors： Wismar J,Habtemichael N,Warren JT,Dai JD,Gilbert LI,Gateff E

更新日期：2000-10-01 00:00:00

abstract：:Using an in vitro model of rat epiphyseal chondrocyte differentiation in which cells are maintained in a three-dimensional cell pellet, we show that exogenous TGF-beta 1 reversibly prevents terminal differentiation of epiphyseal chondrocytes into hypertrophic cells. Through maintenance of gene expression for the carti...

journal_title：Developmental biology

authors： Ballock RT,Heydemann A,Wakefield LM,Flanders KC,Roberts AB,Sporn MB

更新日期：1993-08-01 00:00:00

abstract：:Large steady electrical currents traverse Drosophila follicles in vitro as well as permeabilized eggs. During the period of main follicle growth (stages 9-11), these currents enter the anterior or nurse cell end of the follicles. This inward current acts like a sodium ion influx with some calcium involvement. During t...

journal_title：Developmental biology

authors： Overall R,Jaffe LF

更新日期：1985-03-01 00:00:00

abstract：:The forkhead genes encode a transcription factor involved in embryogenesis and pattern formation in multicellular organisms. They are mammalian transcriptional regulators that bind DNA as a monomer through their forkhead domain. The Foxf2 (LUN) mRNA is expressed in the mesenchyme directly adjacent to the ectoderm-deri...

journal_title：Developmental biology

authors： Wang T,Tamakoshi T,Uezato T,Shu F,Kanzaki-Kato N,Fu Y,Koseki H,Yoshida N,Sugiyama T,Miura N

更新日期：2003-07-01 00:00:00

abstract：:Chick sensory neurons grow to their correct targets in the hindlimb from the outset during normal development and following various experimental manipulations. This may result not because sensory neurons respond to specific limb-derived cues, but because they interact in some way with motoneurons which are responsive ...

journal_title：Developmental biology

authors： Landmesser L,Honig MG

更新日期：1986-12-01 00:00:00

abstract：:In the spawned Xenopus egg, germ plasm is found as cytoplasmic islands spread over a wide cortical region of the vegetal pole. However, by the blastula stage, the same material is found concentrated into a few large blastomeres at the floor of the blastocoel. Components of the germ plasm can be specifically labeled wi...

journal_title：Developmental biology

authors： Savage RM,Danilchik MV

更新日期：1993-06-01 00:00:00

abstract：:Two distinct DNA ligases are expressed during early sea urchin embryogenesis. A light form (50 kDa) is found in unfertilized eggs (oocyte form) and a heavier enzyme (110 kDa) is observed at the two-cell stage (embryonic form). The chronology of the change reveals that the embryonic form is detected 90 min after fertil...

journal_title：Developmental biology

authors： Prigent C,Maniey D,Lefresne J,Epel D,Signoret J,David JC

更新日期：1987-11-01 00:00:00

abstract：:We cloned Xenopus Strabismus (Xstbm), a homologue of the Drosophila planar cell or tissue polarity gene. Xstbm encodes four transmembrane domains in its N-terminal half and a PDZ-binding motif in its C-terminal region, a structure similar to Drosophila and mouse homologues. Xstbm is expressed strongly in the deep cell...

journal_title：Developmental biology

authors： Goto T,Keller R

更新日期：2002-07-01 00:00:00

abstract：:Embryonic 4- to 15-day-old quail ciliary ganglia (CG) were grafted into the neural crest migration pathway of 2-day-old chick embryos at the adrenomedullary level of the neural axis. This back-transplantation results in dispersion of cells of the implanted ganglion, their migration in the host embryo, and subsequent p...

journal_title：Developmental biology

authors： Dupin E

更新日期：1984-10-01 00:00:00

abstract：:The C. elegans Hox gene egl-5 (ortholog of Drosophila Abdominal-B) is expressed in multiple tissues in the tail region and is involved in tail patterning. In this study, we identify and clone the corresponding C. elegans orthologs of the components of the heterotrimeric transcription factor NFY, nfya-1, nfyb-1 and nfy...

journal_title：Developmental biology

authors： Deng H,Sun Y,Zhang Y,Luo X,Hou W,Yan L,Chen Y,Tian E,Han J,Zhang H

更新日期：2007-08-15 00:00:00

abstract：:Elastic fibers are produced during fetal and neonatal periods, and by maturity elastin expression has ceased. Fetal bovine hyaline chondrocytes acquired an elastogenic phenotype within 24 hr after isolation from the tissue, even though the tissue does not produce elastic fibers or tropoelastin mRNA in vivo. By multipl...

journal_title：Developmental biology

authors： Lee KA,Pierce RA,Davis EC,Mecham RP,Parks WC

更新日期：1994-05-01 00:00:00

abstract：:The Hedgehog (Hh) signal transduction pathway plays a central role in the development of invertebrates and vertebrates. While much is known about the pathway, the role of Suppressor of fused (Su(fu)), a component of the pathway's signaling complex has remained enigmatic. Previous studies have linked Su(fu) to the cyto...

journal_title：Developmental biology

authors： Sisson BE,Ziegenhorn SL,Holmgren RA

更新日期：2006-06-01 00:00:00

abstract：:Caudal homeobox genes are found across animals, typically linked to two other homeobox genes in what has been called the ParaHox cluster. These genes have been proposed to pattern the anterior-posterior axis of the endoderm ancestrally, but the expression of Caudal in extant groups is varied and often occurs in other ...

journal_title：Developmental biology

authors： Johnson AB,Lambert JD

更新日期：2021-02-01 00:00:00

abstract：:Developmental effects of six mutations in the gene encoding the majority of alpha-tubulin in all tissues at all stages of Drosophila melanogaster development have been examined. All six alleles produce at least partially stable alpha 84B protein. In genetic assays, two of these alleles approximate the null condition. ...

journal_title：Developmental biology

authors： Matthews KA,Kaufman TC

更新日期：1987-01-01 00:00:00

abstract：:Although communications between mammalian oocytes and their surrounding granulosa cells mediated by the Kit-Kit ligand (KL, or stem cell factor, SCF) system have been proven to be crucial for follicular development, Kit downstream signaling pathways in mammalian oocytes are largely unknown. In this study, by using ova...

journal_title：Developmental biology

authors： Reddy P,Shen L,Ren C,Boman K,Lundin E,Ottander U,Lindgren P,Liu YX,Sun QY,Liu K

更新日期：2005-05-15 00:00:00

abstract：:Alveologenesis is the final step of lung maturation, which subdivides the alveolar region of the lung into smaller units called alveoli. Each of the nascent dividers serves as a new gas-exchange surface, and collectively they drastically increase the surface area for breathing. Disruption of alveologenesis results in ...

journal_title：Developmental biology

authors： Branchfield K,Li R,Lungova V,Verheyden JM,McCulley D,Sun X

更新日期：2016-01-15 00:00:00

abstract：:Proper spatial expression of the wingless (wg) gene in the Drosophila embryonic epidermis is crucial to intrasegmental patterning. Single cell wide wg expression is initiated at the blastoderm stage in response to combinatorial regulation by the pair rule genes. Later, during gastrulation, when the epidermal expressio...

journal_title：Developmental biology

authors： Yoffe KB,Manoukian AS,Wilder EL,Brand AH,Perrimon N

更新日期：1995-08-01 00:00:00

abstract：:Cytotrophoblasts are specialized epithelial cells of the human placenta that differentiate to acquire tumor-like properties that allow them to invade the uterus. Concurrently, they develop endothelial-like characteristics. This transformation allows cytotrophoblasts to replace the maternal cells that line uterine vess...

journal_title：Developmental biology

authors： Zhou Y,Bellingard V,Feng KT,McMaster M,Fisher SJ

更新日期：2003-11-01 00:00:00

abstract：:Zygotic Wnt signaling has been shown to be involved in dorsoventral mesodermal patterning in Xenopus embryos, but how it regulates different myogenic gene expression in the lateral mesodermal domains is not clear. Here, we use transient exposure of embryos or explants to lithium, which mimics Wnt/beta-catenin signalin...

journal_title：Developmental biology

authors： Shi DL,Bourdelas A,Umbhauer M,Boucaut JC

更新日期：2002-05-01 00:00:00

abstract：:The rise of evolutionary developmental biology was not the progressive isolation and characterization of developmental genes and gene networks. Many obstacles had to be overcome: the idea that all genes were more or less involved in development; the evidence that developmental processes in insects had nothing in commo...

journal_title：Developmental biology

authors： Morange M

更新日期：2011-09-01 00:00:00

abstract：:In tetrapods, the anteroposterior (AP) patterning of the limb is under the control of the antagonistic activities of the secreted factor Sonic hedgehog (Shh) and Gli3R, the truncated repressor form of the transcription factor Gli3. In this report, we show that Msx1 and Msx2 are targets and downstream effectors of Gli3...

journal_title：Developmental biology

authors： Lallemand Y,Bensoussan V,Cloment CS,Robert B

更新日期：2009-07-15 00:00:00