Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus.

abstract：:A simple assay has been developed to measure cGMP-specific phosphodiesterase (cGPD) activity in crude soluble extracts of amoebae of Dictyostelium discoideum. When amoebae of different wild-type strains were starved on buffered agar, all strains exhibited an 8- to 12-fold increase in cGMP-specific hydrolyzing activity...

journal_title：Developmental biology

authors： Coukell MB,Cameron AM,Pitre CM,Mee JD

更新日期：1984-05-01 00:00:00

abstract：:We wish to understand how organ-specific structures assemble during embryonic development. In the present paper, we consider what determines the subapical position of the terminal web in the intestinal cells of the nematode Caenorhabditis elegans. The terminal web refers to the organelle-depleted, intermediate filamen...

journal_title：Developmental biology

authors： Bossinger O,Fukushige T,Claeys M,Borgonie G,McGhee JD

更新日期：2004-04-15 00:00:00

abstract：:Stem cells play an essential role in cellular specialization and pattern formation during embryogenesis and in tissue regeneration in adults. This is mainly due to a stem cell's ability to replenish itself (self-renewal) and, at the same time, produce differentiated progeny. Realization of these special stem cell feat...

journal_title：Developmental biology

authors： Zhang J,Li L

更新日期：2005-08-01 00:00:00

abstract：:Stable subdivision of Drosophila limbs into Anterior (A) and Posterior (P) compartments is a consequence of asymmetric signaling by Hedgehog (Hh) from P to A cells. The activity of the homeodomain protein Engrailed (En) in P cells has been reported to help to generate this asymmetry by inducing the expression of hedge...

journal_title：Developmental biology

authors： Bejarano F,Milán M

更新日期：2009-03-15 00:00:00

abstract：:Lineage diversification in the vertebrate neural crest may occur via instructive signals acting on pluripotent cells, and/or via early specification of subpopulations towards particular lineages. Mesencephalic neural crest cells normally form cholinergic parasympathetic neurons in the ciliary ganglion, while trunk neu...

journal_title：Developmental biology

authors： Lee VM,Bronner-Fraser M,Baker CV

更新日期：2005-02-01 00:00:00

abstract：:cAMP chemoattractant receptors on the surface of Dictyostelium discoideum cells are visualized by means of immunocytochemistry. Receptor antigen is virtually absent from growing cells and begins to accumulate after about 6 hr of starvation, concomitant with the increase in surface cAMP binding activity. In aggregating...

journal_title：Developmental biology

authors： Wang M,Van Haastert PJ,Devreotes PN,Schaap P

更新日期：1988-07-01 00:00:00

abstract：:To investigate the molecular regulation of embryonic somite formation and development, we have cloned the full-length cDNA and characterized the embryonic expression profile of chicken Paraxis, a member of a novel family of basic helix-loop-helix (bHLH) proteins, which has been suggested to play a role in paraxial mes...

journal_title：Developmental biology

authors： Barnes GL,Alexander PG,Hsu CW,Mariani BD,Tuan RS

更新日期：1997-09-01 00:00:00

abstract：:POSH (Plenty of SH3s) has distinct roles as a scaffold for specific c-Jun N-terminal kinase (JNK) signaling modules and as an E3 ubiquitin ligase. The physiological function of POSH remains unclear, however, and its possible involvement in developmental processes motivated the present study wherein the Xenopus ortholo...

journal_title：Developmental biology

authors： Kim GH,Park E,Han JK

更新日期：2005-10-01 00:00:00

abstract：:Eph receptors play important roles in axon guidance at the midline. In the auditory system, growth of axons across the midline is an important determinant of auditory function. The avian cochlear nucleus, n. magnocellularis (NM), makes bilateral projections to its target, n. laminaris (NL). We examined the time course...

journal_title：Developmental biology

authors： Cramer KS,Cerretti DP,Siddiqui SA

更新日期：2006-07-01 00:00:00

abstract：:Previous experiments have demonstrated that in the septo-hippocampal system choline acetyltransferase (ChAT) is induced by nerve growth factor (NGF) (Gnahn et al. (1983) Dev. Brain Res. 9, 45-52) and that hippocampal NGF and mRNANGF levels are correlated with the density of cholinergic innervation (Korsching et al. (1...

journal_title：Developmental biology

authors： Auburger G,Heumann R,Hellweg R,Korsching S,Thoenen H

更新日期：1987-04-01 00:00:00

abstract：:Named for its assembly near exon-exon junctions during pre-mRNA splicing, the exon junction complex (EJC) regulates multiple aspects of RNA biochemistry, including export of spliced mRNAs from the nucleus and translation. Transcriptome analyses have revealed broad EJC occupancy of spliced metazoan transcripts, yet inh...

journal_title：Developmental biology

authors： Kimball C,Powers K,Dustin J,Poirier V,Pellettieri J

更新日期：2020-01-01 00:00:00

abstract：:Sonic hedgehog is a secreted factor regulating patterning of the anterior-posterior axis in the developing limb. The signaling pathway mediating the transduction of the signal is still poorly understood. In Drosophila several genes are known to act downstream of hedgehog, the fly homolog of Sonic hedgehog. An importan...

journal_title：Developmental biology

authors： Marigo V,Johnson RL,Vortkamp A,Tabin CJ

更新日期：1996-11-25 00:00:00

abstract：:The origin of resident (noninflammatory) macrophages in vertebrate tissues is still poorly understood. In the zebrafish embryo, we recently described a specific lineage of early macrophages that differentiate in the yolk sac before the onset of blood circulation. We now show that these early macrophages spread in the ...

journal_title：Developmental biology

authors： Herbomel P,Thisse B,Thisse C

更新日期：2001-10-15 00:00:00

abstract：:Because the formation of a mature nerve terminal requires the accumulation of large quantities of synaptic vesicles, the expression of synaptic vesicle proteins would be expected to correlate with synaptogenesis. However, previous studies have provided conflicting evidence on this point. We have examined the developme...

journal_title：Developmental biology

authors： Lou X,Bixby JL

更新日期：1993-09-01 00:00:00

abstract：:Endogenous patterns of retinoic acid (RA) signaling in avian cardiac morphogenesis were characterized by localized expression of a key RA-synthetic enzyme, RALDH2, which displayed a biphasic pattern during heart development. RALDH2 immunoreactivity was initially apparent posterior to Hensen's node of stage 5-6 embryos...

journal_title：Developmental biology

authors： Xavier-Neto J,Shapiro MD,Houghton L,Rosenthal N

更新日期：2000-03-01 00:00:00

abstract：:Regulation of peptide neurotransmitter metabolism was examined in dissociated cell cultures of neonatal rat sympathetic and sensory ganglia. Previous studies have shown that pineal gland conditioned medium (PCM) influences substance P (SP) and somatostatin (SS) metabolism in sympathetic neurons in vitro. The present s...

journal_title：Developmental biology

authors： Kessler JA

更新日期：1984-11-01 00:00:00

abstract：:Developmental patterning and growth of the vertebrate digestive and respiratory tracts requires interactions between the epithelial endoderm and adjacent mesoderm. The esophagus is a specialized structure that connects the digestive and respiratory systems and its normal development is critical for both. Shh signaling...

journal_title：Developmental biology

authors： Korzh S,Winata CL,Zheng W,Yang S,Yin A,Ingham P,Korzh V,Gong Z

更新日期：2011-11-15 00:00:00

abstract：:The C-X-C motif ligand 14 (CXCL14) is a recently discovered chemokine that is highly conserved in vertebrates and expressed in various embryonic and adult tissues. CXCL14 signaling has been implicated to function as an antiangiogenic and anticancer agent in adults. However, its function during development is unknown. ...

journal_title：Developmental biology

authors： Ojeda AF,Munjaal RP,Lwigale PY

更新日期：2017-03-01 00:00:00

abstract：:The dopaminergic neurons of the basal ganglia play critical roles in CNS function and human disease, but specification of dopamine neuron phenotype is poorly understood in vertebrates. We performed an in vivo screen in zebrafish to identify dopaminergic neuron enhancers, in order to facilitate studies on the specifica...

journal_title：Developmental biology

authors： Fujimoto E,Stevenson TJ,Chien CB,Bonkowsky JL

更新日期：2011-04-15 00:00:00

abstract：:To analyse cell migration and the differentiation potential of migratory stem cells in Hydractinia, we generated animals with an eGFP reporter gene stably expressed and transmitted via the germline. The transgene was placed under the control of two different actin promoters and the promoter of elongation factor-1α. On...

journal_title：Developmental biology

authors： Künzel T,Heiermann R,Frank U,Müller W,Tilmann W,Bause M,Nonn A,Helling M,Schwarz RS,Plickert G

更新日期：2010-12-01 00:00:00

abstract：:We demonstrate that interspecific sequence conservation can provide a systematic guide to the identification of functional cis-regulatory elements within a large expanse of genomic DNA. The test was carried out on the otx gene of Strongylocentrotus purpuratus. This gene plays a major role in the gene regulatory networ...

journal_title：Developmental biology

authors： Yuh CH,Brown CT,Livi CB,Rowen L,Clarke PJ,Davidson EH

更新日期：2002-06-01 00:00:00

abstract：:C. elegans ahr-1 is orthologous to the mammalian aryl hydrocarbon receptor, and it functions as a transcription factor to regulate the development of certain neurons. Here, we describe the role of ahr-1 in a specific behavior: the aggregation of C. elegans on lawns of bacterial food. This behavior is modulated by nutr...

journal_title：Developmental biology

authors： Qin H,Zhai Z,Powell-Coffman JA

更新日期：2006-10-15 00:00:00

abstract：:We previously isolated a p53 cDNA from a Xenopus oocyte library. To determine if p53 has a function in the developmental period, we have studied its expression at the RNA and protein levels during the early development of Xenopus laevis. Two p53 transcripts (3 and 2.2 kb) are expressed from the beginning of Xenopus oo...

journal_title：Developmental biology

authors： Tchang F,Gusse M,Soussi T,Méchali M

更新日期：1993-09-01 00:00:00

abstract：:The chick spinal cord can regenerate following injury until advanced developmental stages. It is conceivable that changes in stem/progenitor cell plasticity contribute to the loss of this capacity, which occurs around E13. We investigated the contribution of proliferation, phenotypic changes in radial glia progenitors...

journal_title：Developmental biology

authors： Whalley K,Gögel S,Lange S,Ferretti P

更新日期：2009-08-15 00:00:00

abstract：:Early embryonic cells are capable of acquiring numerous developmental fates until they become irreversibly committed to specific lineages depending on intrinsic determinants and/or regional interactions. From fertilization to gastrulation, such pluripotent cells first increase in number and then turn to undergoing dif...

journal_title：Developmental biology

authors： Nakanoh S,Agata K

更新日期：2019-08-15 00:00:00

abstract：:Mutations in the Pax6 gene disrupt telencephalic development, resulting in a thin cortical plate, expansion of proliferative layers, and the absence of the olfactory bulb. The primary defect in the neuronal cell population of the developing cerebral cortex was analysed by using mouse chimeras containing a mixture of w...

journal_title：Developmental biology

authors： Talamillo A,Quinn JC,Collinson JM,Caric D,Price DJ,West JD,Hill RE

更新日期：2003-03-01 00:00:00

abstract：:Proper spatial expression of the wingless (wg) gene in the Drosophila embryonic epidermis is crucial to intrasegmental patterning. Single cell wide wg expression is initiated at the blastoderm stage in response to combinatorial regulation by the pair rule genes. Later, during gastrulation, when the epidermal expressio...

journal_title：Developmental biology

authors： Yoffe KB,Manoukian AS,Wilder EL,Brand AH,Perrimon N

更新日期：1995-08-01 00:00:00

abstract：:The diaphragm is a mammalian skeletal muscle essential for respiration and for separating the thoracic and abdominal cavities. Development of the diaphragm requires the coordinated development of muscle, muscle connective tissue, tendon, nerves, and vasculature that derive from different embryonic sources. However, de...

journal_title：Developmental biology

authors： Sefton EM,Gallardo M,Kardon G

更新日期：2018-08-15 00:00:00

abstract：:Embryonic 4- to 15-day-old quail ciliary ganglia (CG) were grafted into the neural crest migration pathway of 2-day-old chick embryos at the adrenomedullary level of the neural axis. This back-transplantation results in dispersion of cells of the implanted ganglion, their migration in the host embryo, and subsequent p...

journal_title：Developmental biology

authors： Dupin E

更新日期：1984-10-01 00:00:00

abstract：:Plakoglobin and beta-catenin are cytoplasmic proteins associated with the intracellular plaques of cell adhesive junctions. While plakoglobin is present in both adherens junctions and desmosomes, beta-catenin is associated with the cadherins that accumulate only in adherens junctions. Both beta-catenin and plakoglobin...

journal_title：Developmental biology

authors： DeMarais AA,Moon RT

更新日期：1992-10-01 00:00:00