Abstract:
:Egfr/Ras signaling promotes vein cell fate specification in the developing Drosophila wing. While the importance of Ras signaling in vein determination has been extensively documented, the mechanisms linking Ras activity to vein differentiation remain unclear. We found that Ras signaling regulates both the levels and subcellular localization of the cell adhesion molecule DE-cadherin/Shotgun (Shg) in the differentiating wing epithelium. High Ras activity in presumptive vein cells directs the apical localization of Shg containing adherens junctions, whereas low Ras activity in intervein cells allows Shg to relocalize basally. These alterations in Shg-mediated adhesion control cell shape changes that are essential for vein morphogenesis. While Decapentaplegic (Dpp) acts downstream of Ras to maintain vein cell identity in the pupal wing, our results indicate that Ras controls Shg localization via a Dpp-independent mechanism. Ras, therefore, regulates both the transcriptional responses necessary for vein cell identity, and the cell adhesive changes that determine vein and intervein cell morphology.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
O'Keefe DD,Prober DA,Moyle PS,Rickoll WL,Edgar BAdoi
10.1016/j.ydbio.2007.08.003subject
Has Abstractpub_date
2007-11-01 00:00:00pages
25-39issue
1eissn
0012-1606issn
1095-564Xpii
S0012-1606(07)01245-6journal_volume
311pub_type
杂志文章abstract::Egg yolk phosvitin is one of the most highly phosphorylated extracellular matrix proteins known in nature with unique physico-chemical properties deemed to be critical during ex-vivo egg embryo development. We have utilized our unique live mouse calvarial bone organ culture models under conditions which dissociates th...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2013.06.005
更新日期:2013-09-01 00:00:00
abstract::We present a genetic, developmental and molecular analysis of lethal(1)discs large-1[l(1)d.lg-1; Stewart et al., 1972], an oncogene of Drosophila. Mutations in this gene cause the imaginal discs to grow by cell proliferation beyond their normal final size, transform into solid tumors, fuse with one another and the bra...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(89)90092-4
更新日期:1989-07-01 00:00:00
abstract::In the Drosophila ventral nerve cord, the three pairs of Capability neuropeptide-expressing Va neurons are exclusively found in the second, third and fourth abdominal segments (A2-A4). To address the underlying mechanisms behind such segment-specific cell specification, we followed the developmental specification of t...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2011.02.015
更新日期:2011-05-01 00:00:00
abstract::Adult tissue stem cells self-renew and differentiate in a way that exactly meets the biological demand of the dependent tissue. We evaluated spermatogonial stem cell (SSC) activity in the developing rat testis and the quality and accessibility of the stem cell niche in wild type, and two busulfan-treated models of rat...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2003.07.010
更新日期:2003-11-15 00:00:00
abstract::The subdivision of the developing field by region-specific expression of genes encoding transcription factors is an essential step during appendage development in arthropod and vertebrates. In Drosophila leg development, the distal-most region (pretarsus) is specified by the expression of homeobox genes, aristaless an...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.12.005
更新日期:2005-03-15 00:00:00
abstract::Syndecan, a cell surface proteoglycan, binds multiple extracellular ligands, and is developmentally regulated in epithelial and mesenchymal tissues. The branching morphogenesis of embryonic lung is dependent on epithelial-mesenchymal interactions and, based on studies with inhibitors, on proteoglycan synthesis. To ass...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(91)90286-c
更新日期:1991-10-01 00:00:00
abstract::Exposure of Xenopus animal pole explants to transforming growth factor beta 2 (TGF-beta 2) induced the sequential expression of muscle nicotinic acetylcholine receptor (AChRs) isoforms and their corresponding mRNAs in cells which normally give rise to ectoderm. Single channel recordings revealed two functional classes...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1994.1318
更新日期:1994-11-01 00:00:00
abstract::Molecular mechanisms regulating the remodeling of the lymphatic vasculature from an immature plexus of vessels to a hierarchal network of initial and collecting lymphatics are not well understood. One gene thought to be important for this process is Angiopoietin-2 (Ang-2). Ang2(-/-) mice have previously been reported ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.04.024
更新日期:2008-07-15 00:00:00
abstract::Satellite cells, also known as muscle stem cells, are responsible for skeletal muscle growth and repair in mammals. Pax7 and Pax3 transcription factors are established satellite cell markers required for muscle development and regeneration, and there is great interest in identifying additional factors that regulate sa...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2017.03.004
更新日期:2017-04-15 00:00:00
abstract::Heparan sulfate proteoglycans (HSPGs) regulate a number of major developmental processes, but their roles in synovial joint formation remain unknown. Here we created conditional mouse embryo mutants lacking Ext1 in developing joints by mating Ext1(f/f) and Gdf5-Cre mice. Ext1 encodes a subunit of the Ext1/Ext2 Golgi-a...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2010.12.022
更新日期:2011-03-01 00:00:00
abstract::The chick spinal cord can regenerate following injury until advanced developmental stages. It is conceivable that changes in stem/progenitor cell plasticity contribute to the loss of this capacity, which occurs around E13. We investigated the contribution of proliferation, phenotypic changes in radial glia progenitors...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2009.05.569
更新日期:2009-08-15 00:00:00
abstract::FgfrL1, which interacts with Fgf ligands and heparin, is a member of the fibroblast growth factor receptor (Fgfr) family. FgfrL1-deficient mice show two significant alterations when compared to wildtype mice: They die at birth due to a malformed diaphragm and they lack metanephric kidneys. Utilizing gene arrays, qPCR ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2014.08.016
更新日期:2014-10-15 00:00:00
abstract::pmar1 is a transcription factor in the paired class homeodomain family that was identified and found to be transcribed in micromeres beginning at the fourth cleavage of sea urchin development [Dev. Biol. 246 (2002), 209]. Based on in situ data, molecular perturbation studies, and QPCR data, the recently published gene...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(03)00108-8
更新日期:2003-06-01 00:00:00
abstract::The inner ear, the sensory organ responsible for hearing and balance, contains specialized sensory and non-sensory epithelia arranged in a highly complex three-dimensional structure. To achieve this complexity, a tight coordination between morphogenesis and cell fate specification is essential during otic development....
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.07.025
更新日期:2008-10-01 00:00:00
abstract::Hox genes can function as key drivers of segment identity, with Hox mutations in Drosophila often resulting in dramatic homeotic transformations. In addition, however, they can serve other essential functions. In mammals, the study of Hox gene roles in development is complicated by the presence of four Hox clusters wi...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2018.03.020
更新日期:2018-06-15 00:00:00
abstract::Although local epithelial-mesenchymal tissue interactions which are presumably mediated by extracellular matrix molecules are important regulators of tooth morphogenesis and differentiation, our studies have indicated that these developmental processes also depend on circulating molecules. The iron-carrying serum prot...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(85)90437-3
更新日期:1985-09-01 00:00:00
abstract::Neurogenin (Ngn) 1 and Ngn2 encode basic-helix-loop-helix transcription factors expressed in the developing neocortex. Like other proneural genes, Ngns participate in the specification of neural fates and neuronal identities, but downstream effectors remain poorly defined. We set out to identify Ngn2 effectors in the ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.06.013
更新日期:2004-09-15 00:00:00
abstract::Large steady electrical currents traverse Drosophila follicles in vitro as well as permeabilized eggs. During the period of main follicle growth (stages 9-11), these currents enter the anterior or nurse cell end of the follicles. This inward current acts like a sodium ion influx with some calcium involvement. During t...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(85)90013-2
更新日期:1985-03-01 00:00:00
abstract::Hair shafts are produced from stem cells located in the bulge. Our knowledge of the genetic pathways regulating cell fate acquisition in the immediate descendents of these stem cells, and fate maintenance in their committed progeny, is still incomplete. One pathway involved in fate maintenance within the hair matrix i...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.11.021
更新日期:2009-02-15 00:00:00
abstract::To examine the relationship between growth hormone (GH) and insulin-like growth factor 1 (IGF1) in controlling postnatal growth, we performed a comparative analysis of dwarfing phenotypes manifested in mouse mutants lacking GH receptor, IGF1, or both. This genetic study has provided conclusive evidence demonstrating t...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2000.9975
更新日期:2001-01-01 00:00:00
abstract::Alkaline phosphatase (AP) activity is expressed by endodermal cells of ascidian larvae. It was reported previously that the expression of AP activity is resistant to treatment with actinomycin D, a transcription inhibitor that inhibits the appearance of several other tissue-specific molecules and morphological markers...
journal_title:Developmental biology
pub_type: 杂志文章
doi:
更新日期:1998-06-15 00:00:00
abstract::Axon outgrowth between the spinal cord and the hindlimb of the chick embryo is constrained by three tissues that border axon pathways. Growth cones turn to avoid the posterior sclerotome, perinotochordal mesenchyme, and pelvic girdle precursor during normal development and after experimental manipulation. We wanted to...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(05)80017-x
更新日期:1991-09-01 00:00:00
abstract::Immature, Stage VI oocytes of Xenopus laevis fail to activate (i.e., to propagate a cortical reaction and elevate a fertilization envelope) when pricked or exposed to A23187. We determined the times during maturation when immature oocytes treated with progesterone in vitro developed the capacity to respond to pricking...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(84)90177-5
更新日期:1984-03-01 00:00:00
abstract::Missense mutations in the MYH3 gene encoding myosin heavy chain-embryonic (MyHC-embryonic) have been reported to cause two skeletal muscle contracture syndromes, Freeman Sheldon Syndrome (FSS) and Sheldon Hall Syndrome (SHS). Two residues in MyHC-embryonic that are most frequently mutated, leading to FSS, R672 and T17...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2019.02.017
更新日期:2019-05-15 00:00:00
abstract::The colonial tunicate Botrylloides leachi can regenerate functional adults from minute vasculature fragments, in a poorly understood phenomenon termed Whole Body Regeneration (WBR). Using Piwi expression (Bl-Piwi), blood cell labeling and electron microscopy, we show that WBR develops through activation, mobilization ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2010.05.500
更新日期:2010-09-01 00:00:00
abstract::From July 19-24, 2015, 169 clinicians and basic scientists gathered in the vertiginous heights of Snowmass, Colorado (2502 m) for the fourth FASEB summer research conference on the 'Biology of Cilia and Flagella'. Organizers Maureen Barr (Rutgers University), Iain Drummond (Massachusetts General Hospital/Harvard Medic...
journal_title:Developmental biology
pub_type:
doi:10.1016/j.ydbio.2015.10.030
更新日期:2016-01-15 00:00:00
abstract::The mammalian prostate arises from the urogenital sinus and few factors have been identified to be important in the early stages of prostate development. In this study we show that the transcription factor Sox9 is expressed in the epithelia of all mouse prostatic lobes from the initial stages of their development. We ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.01.030
更新日期:2008-04-15 00:00:00
abstract::The mammalian Cone-rod homeobox (Crx) gene is a divergent member of the Otx gene family known to be involved in differentiation and survival of retinal photoreceptors and photoentrainment of circadian rhythms. Zebrafish have two genes in the Otx5/crx orthology class, and we previously showed that crx can transactivate...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.01.037
更新日期:2004-05-01 00:00:00
abstract::Trypsin-like activity is secreted from eggs of many species at fertilization, and this activity is believed to be critical for the block to polyspermy. Here we show that a cortical granule serine protease of sea urchins is the major and perhaps only protease family member important for fertilization. Zymography assays...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9299
更新日期:1999-07-01 00:00:00
abstract::A polarity in gap junctional permeability normally exists in 32-cell stage Xenopus embryos, in that dorsal cells are relatively more coupled than ventral cells, as measured by transfer of Lucifer yellow dye. The current study extends our analysis of whether gap junctional permeability at this stage can be modulated by...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90227-8
更新日期:1992-05-01 00:00:00