Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration.

abstract：:In the present study, we have investigated the role of tyrosine kinase activity during early retinal development in Xenopus laevis. The protein tyrosine kinase (PTK) inhibitors lavendustin A and genistein were used to determine the possible role of tyrosine kinase activity during retinal development in vivo and in vit...

journal_title：Developmental biology

authors： Li M,Babenko NA,Sakaguchi DS

更新日期：2004-02-01 00:00:00

abstract：:The unc-52 gene of Claenorhabditis elegans encodes a homologue of the basement membrane heparan sulfate proteoglycan perlecan. Viable alleles reduce the abundance of UNC-52 in late larval stages and increase the frequency of distal tip cell (DTC) migration defects caused by mutations disrupting the UNC-6/netrin guidan...

journal_title：Developmental biology

authors： Merz DC,Alves G,Kawano T,Zheng H,Culotti JG

更新日期：2003-04-01 00:00:00

abstract：:Urodele amphibians can regenerate their limbs. During limb regeneration, dermal fibroblasts are transformed into undifferentiated cells called blastema cells. These dermis-blastema cells show multipotency. Such so-called endogenous reprogramming of cell differentiation is one of the main targets of amphibian limb rege...

journal_title：Developmental biology

authors： Makanae A,Hirata A,Honjo Y,Mitogawa K,Satoh A

更新日期：2013-09-01 00:00:00

abstract：:A chronic neuromuscular blockade during those embryonic stages when naturally occurring spinal motoneuron death occurs, results in the prevention of this cell loss. The excess motoneurons are maintained as long as the neuromuscular blockade is continued; once embryonic neuromuscular activity resumes, however, the exce...

journal_title：Developmental biology

authors： Oppenheim RW

更新日期：1984-01-01 00:00:00

abstract：:Soluble N-ethylmalameide-sensitive factor attachment protein receptor (SNARE) proteins are present in mammalian sperm and could be involved in critical membrane fusion events during fertilization, namely the acrosome reaction. Vesicle-associated membrane protein/synaptobrevin, a SNARE on the membrane of a vesicular ca...

journal_title：Developmental biology

authors： Ramalho-Santos J,Moreno RD,Sutovsky P,Chan AW,Hewitson L,Wessel GM,Simerly CR,Schatten G

更新日期：2000-07-01 00:00:00

abstract：:We demonstrate that interspecific sequence conservation can provide a systematic guide to the identification of functional cis-regulatory elements within a large expanse of genomic DNA. The test was carried out on the otx gene of Strongylocentrotus purpuratus. This gene plays a major role in the gene regulatory networ...

journal_title：Developmental biology

authors： Yuh CH,Brown CT,Livi CB,Rowen L,Clarke PJ,Davidson EH

更新日期：2002-06-01 00:00:00

abstract：:Primary sensory olfactory neurons reside in a neuroepithelium lining the nasal cavity and project topographically onto the surface of the olfactory bulb, a rostral extension of the telencephalon. Galectin-1, a bivalent galactose-binding vertebrate lectin, is expressed in the developing rodent olfactory system. In the ...

journal_title：Developmental biology

authors： Puche AC,Poirier F,Hair M,Bartlett PF,Key B

更新日期：1996-10-10 00:00:00

abstract：:Lineage analysis studies in the avian embryo have identified two types of smooth muscle cells (SMCs) in the tunica media of large elastic arteries; one that originates within the cardiac neural crest and is ectoderm in origin (Ect) and another that arises from local mesenchyme of mesodermal origin (Mes). To determine ...

journal_title：Developmental biology

authors： Topouzis S,Majesky MW

更新日期：1996-09-15 00:00:00

abstract：:Monoclonal antibodies highly selective for developmentally regulated antigens present in the cornea (Zak and Linsenmayer, Dev. Biol. 99, 373-381, 1983) have been used to immunohistochemically evaluate differentiation in intact chick corneas cultured on the chorioallantoic membrane (CAM) of host embryos. One antibody i...

journal_title：Developmental biology

authors： Zak NB,Linsenmayer TF

更新日期：1985-04-01 00:00:00

abstract：:The dorsal-ventral axis of the Xenopus embryo is approximately determined by the point of sperm entry, which occurs randomly about the animal-vegetal axis of the egg. Two cytoplasmic components were studied whose spatial arrangements and local concentration patterns appear to reflect the forming dorsal-ventral axis. F...

journal_title：Developmental biology

authors： Phillips CR

更新日期：1985-06-01 00:00:00

abstract：:In the developing heart, the epicardium is essential for coronary vasculogenesis as it provides precursor cells that become coronary vascular smooth muscle and perivascular fibroblasts. These precursor cells are derived from the epicardium via epithelial-mesenchymal transformation (EMT). The factors that regulate epic...

journal_title：Developmental biology

authors： Morabito CJ,Dettman RW,Kattan J,Collier JM,Bristow J

更新日期：2001-06-01 00:00:00

abstract：:Recent data suggest that dental cells utilize the evolutonarily conserved Notch-mediated intercellular signaling pathway to regulate their fates. Here we report on the expression and regulation of Delta1, a transmembrane ligand of the Notch receptors, during mouse odontogenesis. Delta1 is weakly expressed in dental ep...

journal_title：Developmental biology

authors： Mitsiadis TA,Hirsinger E,Lendahl U,Goridis C

更新日期：1998-12-15 00:00:00

abstract：:The contribution of cranial neural crest cells to the development and patterning of cranial muscles in amphibians was investigated in the phylogenetically basal and morphologically generalized frog, Bombina orientalis. Experimental methods included fluorescent marking of premigratory cranial neural crest and extirpati...

journal_title：Developmental biology

authors： Olsson L,Falck P,Lopez K,Cobb J,Hanken J

更新日期：2001-09-15 00:00:00

abstract：:Closure of the cranial neural tube depends on normal development of the head mesenchyme. Homozygous-mutant embryos for the ENU-induced open mind (opm) mutation exhibit exencephaly associated with defects in head mesenchyme development and dorsal-lateral hinge point formation. The head mesenchyme in opm mutant embryos ...

journal_title：Developmental biology

authors： Zohn IE,Anderson KV,Niswander L

更新日期：2007-06-01 00:00:00

abstract：:The structure of the three polypeptide chains of the laminin subunits and the number of glycosylation sites in each polypeptide chain were determined using peptide mapping by high-performance liquid chromatography. Analysis of the [35S]methionine-labeled underglycosylated laminin isolated from tunicamycin (TM)-treated...

journal_title：Developmental biology

authors： Howe CC,Dietzschold B

更新日期：1983-08-01 00:00:00

abstract：:In mouse sex differentiation, SRY promotes Sertoli cell differentiation via SOX9 action, resulting in testis formation. SRY/SOX9 also initiates various testis-specific morphogenic events including glycogenesis in pre-Sertoli cells, suggesting the importance of glucose storage for certain SRY/SOX9-downstream events in ...

journal_title：Developmental biology

authors： Matoba S,Hiramatsu R,Kanai-Azuma M,Tsunekawa N,Harikae K,Kawakami H,Kurohmaru M,Kanai Y

更新日期：2008-12-01 00:00:00

abstract：:Sperm-egg interaction was investigated in mouse eggs freed from the zona pellucida and injected with Clostridium difficile toxin B, the inhibitor of Rho family small G proteins. Toxin B reduced in a dose-dependent manner the percentage of eggs associated with sperm fusion on the surface or sperm nucleus decondensation...

journal_title：Developmental biology

authors： Kumakiri J,Oda S,Kinoshita K,Miyazaki S

更新日期：2003-08-15 00:00:00

abstract：:Acquisition of limb-forming ability by discrete regions of the lateral plate of the chick embryo is thought to depend on a signaling cascade moving sequentially from the area of Hensen's node to the somitic mesoderm, the intermediate mesoderm, and then to the prospective limb-forming regions of the lateral plate (Step...

journal_title：Developmental biology

authors： Dealy CN

更新日期：1997-08-15 00:00:00

abstract：:Eph receptors play important roles in axon guidance at the midline. In the auditory system, growth of axons across the midline is an important determinant of auditory function. The avian cochlear nucleus, n. magnocellularis (NM), makes bilateral projections to its target, n. laminaris (NL). We examined the time course...

journal_title：Developmental biology

authors： Cramer KS,Cerretti DP,Siddiqui SA

更新日期：2006-07-01 00:00:00

abstract：:The thisbe (ths) gene encodes a Drosophila fibroblast growth factor (FGF), and mutant females are viable but sterile suggesting a link between FGF signaling and fertility. Ovaries exhibit abnormal morphology including lack of epithelial sheaths and muscle tissues that surround ovarioles. Here we investigated how FGF i...

journal_title：Developmental biology

authors： Irizarry J,Stathopoulos A

更新日期：2015-08-01 00:00:00

abstract：:This study reports a morphological, skeletal, and molecular characterization of the supernumerary limbs induced by systemic administration of all-trans retinoic acid to egg-cylinder stage mouse embryos. As initially described by Rutledge et al. (Proc. Natl. Acad. Sci. USA 91, 5436, 1994), we have found that oral admin...

journal_title：Developmental biology

authors： Niederreither K,Ward SJ,Dollé P,Chambon P

更新日期：1996-06-15 00:00:00

abstract：:Alveologenesis is the final step of lung maturation, which subdivides the alveolar region of the lung into smaller units called alveoli. Each of the nascent dividers serves as a new gas-exchange surface, and collectively they drastically increase the surface area for breathing. Disruption of alveologenesis results in ...

journal_title：Developmental biology

authors： Branchfield K,Li R,Lungova V,Verheyden JM,McCulley D,Sun X

更新日期：2016-01-15 00:00:00

abstract：:Nontransformed cultures of vascular smooth muscle cells proliferate until they form a confluent sheet of cells. Subsequently, the cells become reorganized to form multicellular nodules that are loosely attached to the substrate. The formation of nodules is facilitated by the addition of medium conditioned by nodular c...

journal_title：Developmental biology

authors： Brennan MJ,Millis AJ,Mann D,Fritz KE

更新日期：1983-06-01 00:00:00

abstract：:Myogenic precursors in adult skeletal muscle (satellite cells) are mitotically quiescent but can proliferate in response to a variety of stresses including muscle injury. To gain further understanding of adult myoblasts, we analyzed myogenesis of satellite cells on intact fibers isolated from adult rat muscle. In this...

journal_title：Developmental biology

authors： Yablonka-Reuveni Z,Rivera AJ

更新日期：1994-08-01 00:00:00

abstract：:We describe mesendoderm morphogenesis during gastrulation in the frog Xenopus laevis and investigate the mechanics of these movements with tissue explants. When a dorsal marginal zone explant is plated onto fibronectin, the mesendoderm moves away from the dorsal axial tissues as an intact sheet. Mesendodermal cells wi...

journal_title：Developmental biology

authors： Davidson LA,Hoffstrom BG,Keller R,DeSimone DW

更新日期：2002-02-15 00:00:00

abstract：:The development of intrinsic ganglia, comprised of neurons and glia cells that innervate airway smooth muscle, is a recognized component of the growing lung. However, the embryological origin of these neurons and glia is unclear. The lung buds develop as an outgrowth of the foregut, which contains migrating neural cre...

journal_title：Developmental biology

authors： Burns AJ,Delalande JM

更新日期：2005-01-01 00:00:00

abstract：:The formation of primary mesenchyme cells in euechinoid sea urchin embryos involves the transformation of 32 epithelial cells into mesenchymal cells in a process referred to as ingression. The mechanism that drives this epithelial-mesenchymal transformation has yet to be identified. Previous studies (J. R. Gibbins, L....

journal_title：Developmental biology

authors： Anstrom JA

更新日期：1989-01-01 00:00:00

abstract：:Proper patterning and growth of oral structures including teeth, tongue, and palate rely on epithelial-mesenchymal interactions involving coordinated regulation of signal transduction. Understanding molecular mechanisms underpinning oral-facial development will provide novel insights into the etiology of common congen...

journal_title：Developmental biology

authors： Lin C,Fisher AV,Yin Y,Maruyama T,Veith GM,Dhandha M,Huang GJ,Hsu W,Ma L

更新日期：2011-08-01 00:00:00

abstract：:Amphibian embryos from the genus Xenopus are among the best species for understanding early vertebrate development and for studying basic cell biological processes. Xenopus, and in particular the diploid Xenopus tropicalis, is also ideal for functional genomics. Understanding the behavior of genes in this accessible m...

journal_title：Developmental biology

authors： Gilchrist MJ,Zorn AM,Voigt J,Smith JC,Papalopulu N,Amaya E

更新日期：2004-07-15 00:00:00

abstract：:Asymmetric cell divisions produce all 302 neurons of the C. elegans hermaphrodite. Here, we describe a role for a C. elegans Dishevelled homolog, DSH-2, in an asymmetric neuroblast division. In dsh-2 mutants, neurons normally descended from the anterior neuroblast daughter of the ABpl/rpppa blast cell were frequently ...

journal_title：Developmental biology

authors： Hawkins NC,Ellis GC,Bowerman B,Garriga G

更新日期：2005-08-01 00:00:00