Abstract：
:The existence of peptidoglycan (PG) in chlamydiae has long been debated. Genome sequencing of members of the Chlamydiaceae family and Protochlamydia amoebophila has uncovered a nearly complete pathway for PG synthesis in these organisms. The recent use of microarray and proteomic analysis methods has revealed that PG synthesis genes are expressed primarily during reticulate body development and division. Furthermore, key genes in the chlamydial PG synthesis pathway encode functional PG synthesis enzymes, some of which provide the basis for the susceptibility of chlamydiae to PG inhibitors. Recent studies shed light on how the construction of a cell wall in chlamydiae is taking shape and why the wall is being built.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
McCoy AJ,Maurelli ATdoi
10.1016/j.tim.2005.12.004subject
Has Abstractpub_date
2006-02-01 00:00:00pages
70-7issue
2eissn
0966-842Xissn
1878-4380pii
S0966-842X(05)00335-5journal_volume
14pub_type
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