Abstract：
:The interferon-inducible, transmembrane protein BST-2 (CD317, tetherin) directly holds fully formed enveloped virus particles to the cells that produce them, inhibiting their spread. BST-2 inhibits members of the retrovirus, filovirus, arenavirus and herpesvirus families. These viruses encode a variety of proteins to degrade BST-2 and/or direct it away from its site of action at the cell surface. Viral antagonism has subjected BST-2 to positive selection, leading to species-specific differences that presented a barrier to the transmission of simian immunodeficiency viruses (SIVs) to humans. This barrier was crossed by HIV-1 when its Vpu protein acquired activity as a BST-2 antagonist. Here, we review this new host-pathogen relationship and discuss its impact on the evolution of primate lentiviruses and the origins of the HIV pandemic.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Evans DT,Serra-Moreno R,Singh RK,Guatelli JCdoi
10.1016/j.tim.2010.06.010subject
Has Abstractpub_date
2010-09-01 00:00:00pages
388-96issue
9eissn
0966-842Xissn
1878-4380pii
S0966-842X(10)00112-5journal_volume
18pub_type
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