Abstract:
:Several features of HIV have frustrated efforts to develop a vaccine able to induce broadly neutralising antibodies. The enormous genetic diversity of HIV is a major factor, accompanied by the camouflaged nature of the envelope spike, upon which HIV depends for cellular entry and to which antibodies must bind to neutralise. The picture is further complicated by the presence of nonfunctional envelope glycoproteins on the surface of HIV that are immunogenic. Consequently, HIV attracts antibodies that do not directly neutralise the virus but still activate complement and engage Fc receptors, which can both enhance and inhibit infection. The various effects that anti-envelope antibodies have on HIV infection will be reviewed here. Further research is needed to determine if these in vitro-characterised activities have relevance in vivo, and if some of the undesirable effects of non-neutralising antibodies can be avoided or the beneficial effects harnessed.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Willey S,Aasa-Chapman MMdoi
10.1016/j.tim.2008.08.008subject
Has Abstractpub_date
2008-12-01 00:00:00pages
596-604issue
12eissn
0966-842Xissn
1878-4380pii
S0966-842X(08)00220-5journal_volume
16pub_type
杂志文章,评审abstract::Because the structure of the tobacco mosaic virus capsid protein is known, mutations that alter the phenotype of the virus-plant interaction can be correlated with structural changes in this protein. These mutations affect the disease symptoms caused by the virus and recognition of the virus by a plant resistance gene...
journal_title:Trends in microbiology
pub_type: 杂志文章
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abstract::Pathogenic Yersinia express a complex array of iron-regulated functions and possess mechanisms for inorganic iron and hemin acquisition. These include a unique temperature-regulated hemin storage system, high-affinity transport processes for hemin and inorganic iron, and an iron-responsive regulatory system controllin...
journal_title:Trends in microbiology
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abstract::New, post-genomic analyses are increasing the rate at which information about highly complex processes such as bacterial growth and development can be acquired. The recent use of DNA-microarray and proteomic analysis to study the differentiating bacterium Caulobacter crescentus has provided the first global view of th...
journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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doi:10.1016/j.tim.2008.06.001
更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/0966-842X(96)10035-4
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journal_title:Trends in microbiology
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abstract::Improved fluorescence techniques for visualizing proteins in whole bacterial cells have resulted in recent breakthroughs in our understanding of chromosome segregation and cytokinesis in prokaryotes. The dynamics and localization of some of these proteins reveal surprisingly cytoskeletal-like behavior. ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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更新日期:1998-06-01 00:00:00
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journal_title:Trends in microbiology
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更新日期:2016-09-01 00:00:00
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pub_type: 历史文章,杂志文章
doi:10.1016/j.tim.2009.05.009
更新日期:2009-08-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2008.12.003
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
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journal_title:Trends in microbiology
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doi:10.1016/j.tim.2007.09.001
更新日期:2007-10-01 00:00:00
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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