Humoral immunity to HIV-1: neutralisation and antibody effector functions.

Abstract:

:Several features of HIV have frustrated efforts to develop a vaccine able to induce broadly neutralising antibodies. The enormous genetic diversity of HIV is a major factor, accompanied by the camouflaged nature of the envelope spike, upon which HIV depends for cellular entry and to which antibodies must bind to neutralise. The picture is further complicated by the presence of nonfunctional envelope glycoproteins on the surface of HIV that are immunogenic. Consequently, HIV attracts antibodies that do not directly neutralise the virus but still activate complement and engage Fc receptors, which can both enhance and inhibit infection. The various effects that anti-envelope antibodies have on HIV infection will be reviewed here. Further research is needed to determine if these in vitro-characterised activities have relevance in vivo, and if some of the undesirable effects of non-neutralising antibodies can be avoided or the beneficial effects harnessed.

journal_name

Trends Microbiol

journal_title

Trends in microbiology

authors

Willey S,Aasa-Chapman MM

doi

10.1016/j.tim.2008.08.008

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

596-604

issue

12

eissn

0966-842X

issn

1878-4380

pii

S0966-842X(08)00220-5

journal_volume

16

pub_type

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