听力与言语-语言病理学

行为科学

医学伦理学

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  • Oceanic Hitchhikers - Assessing Pathogen Risks from Marine Microplastic.

    abstract::As plastic debris in the environment continues to increase, an emerging concern is the potential for microplastic to act as vectors for pathogen transport. With aquaculture the fastest growing food sector, and microplastic contamination of shellfish increasingly demonstrated, understanding any risk of pathogen transpo...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2020.06.011

    authors: Bowley J,Baker-Austin C,Porter A,Hartnell R,Lewis C

    更新日期:2021-02-01 00:00:00

  • Demystifying Cell Cycle Arrest by HIV-1 Vif.

    abstract::Although APOBEC3 degradation is the canonical function of HIV-1 Vif, this viral protein also induces potent cell cycle arrest through a newly defined mechanism. Here, we review recent advances in this area and propose that the scope of this activity may go beyond subversion of the host cell cycle. ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章

    doi:10.1016/j.tim.2021.01.001

    authors: Salamango DJ,Harris RS

    更新日期:2021-01-19 00:00:00

  • Noncoding RNAs: Regulatory Molecules of Host-Microbiome Crosstalk.

    abstract::Recent emerging evidence has revealed that regulatory noncoding RNAs (microRNAs, circular RNAs) modulate host-microbe interactions and they have been proposed as potential biomarkers of the host's response to microbiome-linked pathologies such as cancers, obesity, and neurodegenerative diseases. Interactions between m...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2020.12.003

    authors: Malmuthuge N,Guan LL

    更新日期:2021-01-05 00:00:00

  • Sex-biased Immune Responses Following SARS-CoV-2 Infection.

    abstract::Males are disproportionately affected by severe disease and death from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In their recent article, Takahashi et al. found sex differences in immune responses to SARS-CoV-2 and the predictors of disease progression. These findings contribute to elucid...

    journal_title:Trends in microbiology

    pub_type: 评论,杂志文章

    doi:10.1016/j.tim.2020.10.002

    authors: Ursin RL,Shapiro JR,Klein SL

    更新日期:2020-12-01 00:00:00

  • Fungal Pathogens: Shape-Shifting Invaders.

    abstract::Fungal infections are on the rise due to new medical procedures that have increased the number of immune compromised patients, antibacterial antibiotics that disrupt the microbiome, and increased use of indwelling medical devices that provide sites for biofilm formation. Key to understanding the mechanisms of pathogen...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2020.05.001

    authors: Min K,Neiman AM,Konopka JB

    更新日期:2020-11-01 00:00:00

  • The Molecular Language of the Cnidarian-Dinoflagellate Symbiosis.

    abstract::The cnidarian-dinoflagellate symbiosis is of huge importance as it underpins the success of coral reefs, yet we know very little about how the host cnidarian and its dinoflagellate endosymbionts communicate with each other to form a functionally integrated unit. Here, we review the current knowledge of interpartner mo...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2020.08.005

    authors: Rosset SL,Oakley CA,Ferrier-Pagès C,Suggett DJ,Weis VM,Davy SK

    更新日期:2020-09-23 00:00:00

  • Two Dietary Metabolites Fuel Salmonella Colonization.

    abstract::Nguyen et al. used transposon sequencing analysis and competitive colonization assays to describe how aspartate/malate can trigger initial Salmonella Typhimurium gut-lumen colonization in mice, providing insight into the significance of certain key metabolites beyond the realm of Salmonella life. Metabolite-driven dia...

    journal_title:Trends in microbiology

    pub_type: 评论,杂志文章

    doi:10.1016/j.tim.2020.06.007

    authors: Jepsen S,Jiang S

    更新日期:2020-09-01 00:00:00

  • Roles of Thermokarst Lakes in a Warming World.

    abstract::Permafrost covers a quarter of the northern hemisphere land surface and contains twice the amount of carbon that is currently present in the atmosphere. Future climate change is expected to reduce its near-surface cover by over 90% by the end of the 21st century, leading to thermokarst lake formation. Thermokarst lake...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2020.04.002

    authors: In 't Zandt MH,Liebner S,Welte CU

    更新日期:2020-09-01 00:00:00

  • Positive Interactions in the Coral Macro and Microbiome.

    abstract::Researchers now recognize the importance of the coral microbiome, but they often overlook other species that live on corals and influence coral-microbe interactions. These 'interstitial associates' should be incorporated into the metaorganism concept for insights into how facilitations between associates, corals, and ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章

    doi:10.1016/j.tim.2020.02.009

    authors: Ainsworth TD,Renzi JJ,Silliman BR

    更新日期:2020-08-01 00:00:00

  • A Gaseous Milieu: Extending the Boundaries of the Rhizosphere.

    abstract::Plant root activities shape microbial community functioning in the soil, making the rhizosphere the epicenter of soil biogeochemical processes. With this opinion article, we argue to rethink the rhizosphere boundaries: as gases can diffuse several centimeters away from the roots into the soil, the portion of soil infl...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2020.02.016

    authors: de la Porte A,Schmidt R,Yergeau É,Constant P

    更新日期:2020-07-01 00:00:00

  • Tracing the Origin of Invasive Fungal Infections.

    abstract::Invasive fungal infections are a major cause of mortality in immunocompromised patients. By using high-resolution sequencing, Zhai et al. provide insight into translocation of Candida strains from the gut mycobiota to the bloodstream of transplanted patients. Microbiota-driven diagnostic methods could rapidly emerge f...

    journal_title:Trends in microbiology

    pub_type: 评论,杂志文章

    doi:10.1016/j.tim.2020.01.007

    authors: Papon N,Bougnoux ME,d'Enfert C

    更新日期:2020-04-01 00:00:00

  • Networks Consolidate the Core Concepts of Evolution by Natural Selection.

    abstract::Microbiology has unraveled rich evidence of ongoing reticulate evolutionary processes and complex interactions both within and between cells. These phenomena feature real biological networks, which can logically be analyzed using network-based tools. It is thus not surprising that network sciences, a field independent...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2019.11.006

    authors: Papale F,Saget J,Bapteste É

    更新日期:2020-04-01 00:00:00

  • Multifaceted Roles of TIM-Family Proteins in Virus-Host Interactions.

    abstract::To enhance infection, enveloped viruses exploit adhesion molecules expressed on the surface of host cells. Specifically, phosphatidylserine (PS) receptors - including members of the human T cell immunoglobulin and mucin domain (TIM)-family - have gained attention for their ability to mediate the entry of many envelope...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2019.10.004

    authors: Evans JP,Liu SL

    更新日期:2020-03-01 00:00:00

  • Sexual Selection in Bacteria?

    abstract::A main mechanism of lateral gene transfer in bacteria is transformation, where cells take up free DNA from the environment which subsequently can be recombined into the genome. Bacteria are also known to actively release DNA into the environment through secretion or lysis, which could aid uptake via transformation. Va...

    journal_title:Trends in microbiology

    pub_type: 杂志文章

    doi:10.1016/j.tim.2019.07.009

    authors: Vos M,Buckling A,Kuijper B

    更新日期:2019-12-01 00:00:00

  • The MSCRAMM Family of Cell-Wall-Anchored Surface Proteins of Gram-Positive Cocci.

    abstract::The microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) are a family of proteins that are defined by the presence of two adjacent IgG-like folded subdomains. These promote binding to ligands by mechanisms that involve major conformational changes exemplified by the binding to fibrinogen by th...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2019.06.007

    authors: Foster TJ

    更新日期:2019-11-01 00:00:00

  • Contribution of the Mucosal Microbiota to Bovine Respiratory Health.

    abstract::Recognizing the respiratory tract as a dynamic and complex ecosystem has enhanced our understanding of the pathophysiology of bovine respiratory disease (BRD). There is widespread evidence showing that disease-predisposing factors often disrupt the respiratory microbial ecosystem, provoking atypical colonization patte...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2019.04.005

    authors: Zeineldin M,Lowe J,Aldridge B

    更新日期:2019-09-01 00:00:00

  • Embracing Environmental Genomics and Machine Learning for Routine Biomonitoring.

    abstract::Genomics is fast becoming a routine tool in medical diagnostics and cutting-edge biotechnologies. Yet, its use for environmental biomonitoring is still considered a futuristic ideal. Until now, environmental genomics was mainly used as a replacement of the burdensome morphological identification, to screen known morph...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2018.10.012

    authors: Cordier T,Lanzén A,Apothéloz-Perret-Gentil L,Stoeck T,Pawlowski J

    更新日期:2019-05-01 00:00:00

  • RTX Adhesins are Key Bacterial Surface Megaproteins in the Formation of Biofilms.

    abstract::Gram-negative bacteria produce repeats-in-toxin adhesion proteins (RTX adhesins) to facilitate microbial adhesion. These large, multidomain proteins share a common architecture comprised of four regions. First to emerge from the bacterium, C terminal end leading, is the RTX export sequence that directs the protein thr...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2018.12.003

    authors: Guo S,Vance TDR,Stevens CA,Voets I,Davies PL

    更新日期:2019-05-01 00:00:00

  • The Pathogen-Host Interface in Three Dimensions: Correlative FIB/SEM Applications.

    abstract::Pathogens survive and propagate within host cells through a wide array of complex interactions. Tracking the molecular and cellular events by multidimensional fluorescence microscopy has been a widespread tool for research on intracellular pathogens. Through major advancements in 3D electron microscopy, intracellular ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2018.11.011

    authors: Weiner A,Enninga J

    更新日期:2019-05-01 00:00:00

  • Misperceived Risks of Zika-related Microcephaly in India.

    abstract::After the discovery that Zika virus (ZIKV) could cause microcephaly and other birth defects, we have scrambled to understand how. Now, spreading along with the virus is misinformation that a ZIKV mutation is responsible for microcephaly. Putting too much onus on a single mutation could enhance a crisis in India. ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2019.02.004

    authors: Grubaugh ND,Ishtiaq F,Setoh YX,Ko AI

    更新日期:2019-05-01 00:00:00

  • Phage Therapy: Going Temperate?

    abstract::Strictly lytic phages have been consensually preferred for phage therapy purposes. In contrast, temperate phages have been avoided due to an inherent capacity to mediate transfer of genes between bacteria by specialized transduction - an event that may increase bacterial virulence, for example, by promoting antibiotic...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2018.10.008

    authors: Monteiro R,Pires DP,Costa AR,Azeredo J

    更新日期:2019-04-01 00:00:00

  • Integrated Signaling Pathways Mediate Bordetella Immunomodulation, Persistence, and Transmission.

    abstract::The mammalian immune system includes a sophisticated array of antimicrobial mechanisms. However, successful pathogens have developed subversive strategies to detect, modulate, and/or evade immune control and clearance. Independent disciplines study host immunology and bacterial pathogenesis, but interkingdom signaling...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2018.09.010

    authors: Gestal MC,Whitesides LT,Harvill ET

    更新日期:2019-02-01 00:00:00

  • The Human Microbiome and Child Growth - First 1000 Days and Beyond.

    abstract::The assembly of microbial communities within the gastrointestinal tract during early life plays a critical role in immune, endocrine, metabolic, and other host developmental pathways. Environmental insults during this period, such as food insecurity and infections, can disrupt this optimal microbial succession, which ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2018.09.008

    authors: Robertson RC,Manges AR,Finlay BB,Prendergast AJ

    更新日期:2019-02-01 00:00:00

  • Can β-Lactam Antibiotics Be Resurrected to Combat MRSA?

    abstract::The use of β-lactam antibiotics to treat infections caused by Staphylococcus aureus has been severely compromised by the acquisition by horizontal gene transfer of a gene that encodes the β-lactam-insensitive penicillin-binding protein PBP2a. This allows methicillin-resistant S. aureus (MRSA) to proliferate in the pre...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2018.06.005

    authors: Foster TJ

    更新日期:2019-01-01 00:00:00

  • Building Walls: Work That Never Ends.

    abstract::Fluorescent amino acid analogs have proven to be useful tools for studying the dynamics of peptidoglycan metabolism. García-Heredia and colleagues showed that their route of incorporation differs depending on the adjunct fluorophore and applied this property to investigate mycobacterial peptidoglycan synthesis and rem...

    journal_title:Trends in microbiology

    pub_type: 评论,杂志文章

    doi:10.1016/j.tim.2018.11.006

    authors: Botella H,Vaubourgeix J

    更新日期:2019-01-01 00:00:00

  • From Theory to Practice: Translating Whole-Genome Sequencing (WGS) into the Clinic.

    abstract::Hospitals worldwide are facing an increasing incidence of hard-to-treat infections. Limiting infections and providing patients with optimal drug regimens require timely strain identification as well as virulence and drug-resistance profiling. Additionally, prophylactic interventions based on the identification of envi...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2018.08.004

    authors: Balloux F,Brønstad Brynildsrud O,van Dorp L,Shaw LP,Chen H,Harris KA,Wang H,Eldholm V

    更新日期:2018-12-01 00:00:00

  • HIV-1 Latency Is Maintained by the Estrogen Receptor.

    abstract::Persistence of the latent reservoir remains a challenge to curing HIV infection. Using shRNA screening, new insights into the molecular mechanisms underlying latency regulation indicate that the estrogen receptor is a potent repressor of proviral reactivation and may serve as a promising therapeutic target in combinat...

    journal_title:Trends in microbiology

    pub_type: 评论,杂志文章

    doi:10.1016/j.tim.2018.09.005

    authors: Bick AJ,Hapgood JP

    更新日期:2018-11-01 00:00:00

  • Influenza Hemagglutinin Protein Stability, Activation, and Pandemic Risk.

    abstract::For decades, hemagglutinin (HA) protein structure and its refolding mechanism have served as a paradigm for understanding protein-mediated membrane fusion. HA trimers are in a high-energy state and are functionally activated by low pH. Over the past decade, HA stability (or the pH at which irreversible conformational ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2018.03.005

    authors: Russell CJ,Hu M,Okda FA

    更新日期:2018-10-01 00:00:00

  • Exhaustion and Inflation at Antipodes of T Cell Responses to Chronic Virus Infection.

    abstract::Viruses that have coevolved with their host establish chronic infections that are well tolerated by the host. Other viruses, that are partly adapted to their host, may induce chronic infections where persistent replication and viral antigen expression occur. The former induce highly functional and resilient CD8T cell ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2017.11.012

    authors: Cicin-Sain L,Arens R

    更新日期:2018-06-01 00:00:00

  • A Call to Arms: Quest for a Cryptococcal Vaccine.

    abstract::Cryptococcosis remains a significant cause of morbidity and mortality world-wide, particularly among AIDS patients. Yet, to date, there are no licensed vaccines clinically available to treat or prevent cryptococcosis. In this review, we provide a rationale to support continued investment in Cryptococcus vaccine resear...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2017.10.002

    authors: Caballero Van Dyke MC,Wormley FL Jr

    更新日期:2018-05-01 00:00:00

  • Cable Bacteria Take a New Breath Using Long-Distance Electricity.

    abstract::Recently, a new group of multicellular microorganisms was discovered, called 'cable bacteria', which are capable of generating and mediating electrical currents across centimetre-scale distances. By transporting electrons from cell to cell, cable bacteria can harvest electron donors and electron acceptors that are wid...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2017.10.011

    authors: Meysman FJR

    更新日期:2018-05-01 00:00:00

  • Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion.

    abstract::Deadly infections from opportunistic fungi have risen in frequency, largely because of the at-risk immunocompromised population created by advances in modern medicine and the HIV/AIDS pandemic. This review focuses on dynamics of the fungal polysaccharide cell wall, which plays an outsized role in fungal pathogenesis a...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2018.01.007

    authors: Hopke A,Brown AJP,Hall RA,Wheeler RT

    更新日期:2018-04-01 00:00:00

  • End-in-Sight: Cell Polarization by the Polygamic Organizer PopZ.

    abstract::Understanding how asymmetries in cellular constituents are achieved and how such positional information directs the construction of structures in a nonrandom fashion is a fundamental problem in cell biology. The recent identification of determinants that self-assemble into macromolecular complexes at the bacterial cel...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2017.11.007

    authors: Bergé M,Viollier PH

    更新日期:2018-04-01 00:00:00

  • Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.

    abstract::Microbial pathogens possess a diversity of weapons that disrupt host homeostasis and immune defenses, thus resulting in the establishment of infection. The best-characterized system mediating bacterial protein delivery into target eukaryotic cells is the type III secretion system (T3SS) expressed by Gram-negative bact...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2018.01.010

    authors: Pinaud L,Sansonetti PJ,Phalipon A

    更新日期:2018-04-01 00:00:00

  • Legionella Effectors Explored with INSeq: New Functional Insights.

    abstract::Legionella pneumophila secretes over 300 effector proteins that manipulate host cells. This multiplicity of effectors hampers the characterization of their individual roles. Shames et al. report a new approach to solve the enigma of Legionella effector function by using INSeq to analyse effector functions in the conte...

    journal_title:Trends in microbiology

    pub_type: 评论,杂志文章

    doi:10.1016/j.tim.2018.01.003

    authors: Rolando M,Buchrieser C

    更新日期:2018-03-01 00:00:00

  • Life on Phosphite: A Metagenomics Tale.

    abstract::Phosphite, a species of phosphorus in a P3+ oxidation state, is believed to have played an important role in the primordial Earth. Figueroa et al. used metagenomics to uncover anaerobic bacterial communities from waste water waste sludge that sustain life from energy provided by phosphite. ...

    journal_title:Trends in microbiology

    pub_type: 评论,杂志文章

    doi:10.1016/j.tim.2018.01.002

    authors: Tapia-Torres Y,Olmedo-Álvarez G

    更新日期:2018-03-01 00:00:00

  • Influenza H3N2 Vaccines: Recent Challenges.

    abstract::H3N2-subtype influenza A viruses are major causes of seasonal influenza epidemics. Emerging H3N2 variants require the annual adjustment of the vaccine strain. Recently, studies addressing the reduced effectiveness of current H3N2 vaccines have identified production-related substitutions in the viral hemagglutinin anti...

    journal_title:Trends in microbiology

    pub_type: 评论,杂志文章

    doi:10.1016/j.tim.2017.12.003

    authors: Mostafa A,Pleschka S

    更新日期:2018-02-01 00:00:00

  • Predictive Modeling of Influenza Shows the Promise of Applied Evolutionary Biology.

    abstract::Seasonal influenza is controlled through vaccination campaigns. Evolution of influenza virus antigens means that vaccines must be updated to match novel strains, and vaccine effectiveness depends on the ability of scientists to predict nearly a year in advance which influenza variants will dominate in upcoming seasons...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2017.09.004

    authors: Morris DH,Gostic KM,Pompei S,Bedford T,Łuksza M,Neher RA,Grenfell BT,Lässig M,McCauley JW

    更新日期:2018-02-01 00:00:00

  • In Silico Vaccine Strain Prediction for Human Influenza Viruses.

    abstract::Vaccines preventing seasonal influenza infections save many lives every year; however, due to rapid viral evolution, they have to be updated frequently to remain effective. To identify appropriate vaccine strains, the World Health Organization (WHO) operates a global program that continually generates and interprets s...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2017.09.001

    authors: Klingen TR,Reimering S,Guzmán CA,McHardy AC

    更新日期:2018-02-01 00:00:00

  • The Role of the Fungal Cell Wall in the Infection of Plants.

    abstract::The polysaccharide-rich wall, which envelopes the fungal cell, is pivotal to the maintenance of cellular integrity and for the protection of the cell from external aggressors - such as environmental fluxes and during host infection. This review considers the commonalities in the composition of the wall across the fung...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2017.05.015

    authors: Geoghegan I,Steinberg G,Gurr S

    更新日期:2017-12-01 00:00:00

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