解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::As plastic debris in the environment continues to increase, an emerging concern is the potential for microplastic to act as vectors for pathogen transport. With aquaculture the fastest growing food sector, and microplastic contamination of shellfish increasingly demonstrated, understanding any risk of pathogen transpo...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2020.06.011
更新日期:2021-02-01 00:00:00
abstract::Although APOBEC3 degradation is the canonical function of HIV-1 Vif, this viral protein also induces potent cell cycle arrest through a newly defined mechanism. Here, we review recent advances in this area and propose that the scope of this activity may go beyond subversion of the host cell cycle. ...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2021.01.001
更新日期:2021-01-19 00:00:00
abstract::Recent emerging evidence has revealed that regulatory noncoding RNAs (microRNAs, circular RNAs) modulate host-microbe interactions and they have been proposed as potential biomarkers of the host's response to microbiome-linked pathologies such as cancers, obesity, and neurodegenerative diseases. Interactions between m...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2020.12.003
更新日期:2021-01-05 00:00:00
abstract::Males are disproportionately affected by severe disease and death from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In their recent article, Takahashi et al. found sex differences in immune responses to SARS-CoV-2 and the predictors of disease progression. These findings contribute to elucid...
journal_title:Trends in microbiology
pub_type: 评论,杂志文章
doi:10.1016/j.tim.2020.10.002
更新日期:2020-12-01 00:00:00
abstract::Fungal infections are on the rise due to new medical procedures that have increased the number of immune compromised patients, antibacterial antibiotics that disrupt the microbiome, and increased use of indwelling medical devices that provide sites for biofilm formation. Key to understanding the mechanisms of pathogen...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2020.05.001
更新日期:2020-11-01 00:00:00
abstract::The cnidarian-dinoflagellate symbiosis is of huge importance as it underpins the success of coral reefs, yet we know very little about how the host cnidarian and its dinoflagellate endosymbionts communicate with each other to form a functionally integrated unit. Here, we review the current knowledge of interpartner mo...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2020.08.005
更新日期:2020-09-23 00:00:00
abstract::Nguyen et al. used transposon sequencing analysis and competitive colonization assays to describe how aspartate/malate can trigger initial Salmonella Typhimurium gut-lumen colonization in mice, providing insight into the significance of certain key metabolites beyond the realm of Salmonella life. Metabolite-driven dia...
journal_title:Trends in microbiology
pub_type: 评论,杂志文章
doi:10.1016/j.tim.2020.06.007
更新日期:2020-09-01 00:00:00
abstract::Permafrost covers a quarter of the northern hemisphere land surface and contains twice the amount of carbon that is currently present in the atmosphere. Future climate change is expected to reduce its near-surface cover by over 90% by the end of the 21st century, leading to thermokarst lake formation. Thermokarst lake...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2020.04.002
更新日期:2020-09-01 00:00:00
abstract::Researchers now recognize the importance of the coral microbiome, but they often overlook other species that live on corals and influence coral-microbe interactions. These 'interstitial associates' should be incorporated into the metaorganism concept for insights into how facilitations between associates, corals, and ...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2020.02.009
更新日期:2020-08-01 00:00:00
abstract::Plant root activities shape microbial community functioning in the soil, making the rhizosphere the epicenter of soil biogeochemical processes. With this opinion article, we argue to rethink the rhizosphere boundaries: as gases can diffuse several centimeters away from the roots into the soil, the portion of soil infl...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2020.02.016
更新日期:2020-07-01 00:00:00
abstract::Invasive fungal infections are a major cause of mortality in immunocompromised patients. By using high-resolution sequencing, Zhai et al. provide insight into translocation of Candida strains from the gut mycobiota to the bloodstream of transplanted patients. Microbiota-driven diagnostic methods could rapidly emerge f...
journal_title:Trends in microbiology
pub_type: 评论,杂志文章
doi:10.1016/j.tim.2020.01.007
更新日期:2020-04-01 00:00:00
abstract::Microbiology has unraveled rich evidence of ongoing reticulate evolutionary processes and complex interactions both within and between cells. These phenomena feature real biological networks, which can logically be analyzed using network-based tools. It is thus not surprising that network sciences, a field independent...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2019.11.006
更新日期:2020-04-01 00:00:00
abstract::To enhance infection, enveloped viruses exploit adhesion molecules expressed on the surface of host cells. Specifically, phosphatidylserine (PS) receptors - including members of the human T cell immunoglobulin and mucin domain (TIM)-family - have gained attention for their ability to mediate the entry of many envelope...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2019.10.004
更新日期:2020-03-01 00:00:00
abstract::A main mechanism of lateral gene transfer in bacteria is transformation, where cells take up free DNA from the environment which subsequently can be recombined into the genome. Bacteria are also known to actively release DNA into the environment through secretion or lysis, which could aid uptake via transformation. Va...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2019.07.009
更新日期:2019-12-01 00:00:00
abstract::The microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) are a family of proteins that are defined by the presence of two adjacent IgG-like folded subdomains. These promote binding to ligands by mechanisms that involve major conformational changes exemplified by the binding to fibrinogen by th...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2019.06.007
更新日期:2019-11-01 00:00:00
abstract::Recognizing the respiratory tract as a dynamic and complex ecosystem has enhanced our understanding of the pathophysiology of bovine respiratory disease (BRD). There is widespread evidence showing that disease-predisposing factors often disrupt the respiratory microbial ecosystem, provoking atypical colonization patte...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2019.04.005
更新日期:2019-09-01 00:00:00
abstract::Genomics is fast becoming a routine tool in medical diagnostics and cutting-edge biotechnologies. Yet, its use for environmental biomonitoring is still considered a futuristic ideal. Until now, environmental genomics was mainly used as a replacement of the burdensome morphological identification, to screen known morph...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.10.012
更新日期:2019-05-01 00:00:00
abstract::Gram-negative bacteria produce repeats-in-toxin adhesion proteins (RTX adhesins) to facilitate microbial adhesion. These large, multidomain proteins share a common architecture comprised of four regions. First to emerge from the bacterium, C terminal end leading, is the RTX export sequence that directs the protein thr...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.12.003
更新日期:2019-05-01 00:00:00
abstract::Pathogens survive and propagate within host cells through a wide array of complex interactions. Tracking the molecular and cellular events by multidimensional fluorescence microscopy has been a widespread tool for research on intracellular pathogens. Through major advancements in 3D electron microscopy, intracellular ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.11.011
更新日期:2019-05-01 00:00:00
abstract::After the discovery that Zika virus (ZIKV) could cause microcephaly and other birth defects, we have scrambled to understand how. Now, spreading along with the virus is misinformation that a ZIKV mutation is responsible for microcephaly. Putting too much onus on a single mutation could enhance a crisis in India. ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2019.02.004
更新日期:2019-05-01 00:00:00
abstract::Strictly lytic phages have been consensually preferred for phage therapy purposes. In contrast, temperate phages have been avoided due to an inherent capacity to mediate transfer of genes between bacteria by specialized transduction - an event that may increase bacterial virulence, for example, by promoting antibiotic...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.10.008
更新日期:2019-04-01 00:00:00
abstract::The mammalian immune system includes a sophisticated array of antimicrobial mechanisms. However, successful pathogens have developed subversive strategies to detect, modulate, and/or evade immune control and clearance. Independent disciplines study host immunology and bacterial pathogenesis, but interkingdom signaling...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.09.010
更新日期:2019-02-01 00:00:00
abstract::The assembly of microbial communities within the gastrointestinal tract during early life plays a critical role in immune, endocrine, metabolic, and other host developmental pathways. Environmental insults during this period, such as food insecurity and infections, can disrupt this optimal microbial succession, which ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.09.008
更新日期:2019-02-01 00:00:00
abstract::The use of β-lactam antibiotics to treat infections caused by Staphylococcus aureus has been severely compromised by the acquisition by horizontal gene transfer of a gene that encodes the β-lactam-insensitive penicillin-binding protein PBP2a. This allows methicillin-resistant S. aureus (MRSA) to proliferate in the pre...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.06.005
更新日期:2019-01-01 00:00:00
abstract::Fluorescent amino acid analogs have proven to be useful tools for studying the dynamics of peptidoglycan metabolism. García-Heredia and colleagues showed that their route of incorporation differs depending on the adjunct fluorophore and applied this property to investigate mycobacterial peptidoglycan synthesis and rem...
journal_title:Trends in microbiology
pub_type: 评论,杂志文章
doi:10.1016/j.tim.2018.11.006
更新日期:2019-01-01 00:00:00
abstract::Hospitals worldwide are facing an increasing incidence of hard-to-treat infections. Limiting infections and providing patients with optimal drug regimens require timely strain identification as well as virulence and drug-resistance profiling. Additionally, prophylactic interventions based on the identification of envi...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.08.004
更新日期:2018-12-01 00:00:00
abstract::Persistence of the latent reservoir remains a challenge to curing HIV infection. Using shRNA screening, new insights into the molecular mechanisms underlying latency regulation indicate that the estrogen receptor is a potent repressor of proviral reactivation and may serve as a promising therapeutic target in combinat...
journal_title:Trends in microbiology
pub_type: 评论,杂志文章
doi:10.1016/j.tim.2018.09.005
更新日期:2018-11-01 00:00:00
abstract::For decades, hemagglutinin (HA) protein structure and its refolding mechanism have served as a paradigm for understanding protein-mediated membrane fusion. HA trimers are in a high-energy state and are functionally activated by low pH. Over the past decade, HA stability (or the pH at which irreversible conformational ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.03.005
更新日期:2018-10-01 00:00:00
abstract::Viruses that have coevolved with their host establish chronic infections that are well tolerated by the host. Other viruses, that are partly adapted to their host, may induce chronic infections where persistent replication and viral antigen expression occur. The former induce highly functional and resilient CD8T cell ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2017.11.012
更新日期:2018-06-01 00:00:00
abstract::Cryptococcosis remains a significant cause of morbidity and mortality world-wide, particularly among AIDS patients. Yet, to date, there are no licensed vaccines clinically available to treat or prevent cryptococcosis. In this review, we provide a rationale to support continued investment in Cryptococcus vaccine resear...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2017.10.002
更新日期:2018-05-01 00:00:00
abstract::Recently, a new group of multicellular microorganisms was discovered, called 'cable bacteria', which are capable of generating and mediating electrical currents across centimetre-scale distances. By transporting electrons from cell to cell, cable bacteria can harvest electron donors and electron acceptors that are wid...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2017.10.011
更新日期:2018-05-01 00:00:00
abstract::Deadly infections from opportunistic fungi have risen in frequency, largely because of the at-risk immunocompromised population created by advances in modern medicine and the HIV/AIDS pandemic. This review focuses on dynamics of the fungal polysaccharide cell wall, which plays an outsized role in fungal pathogenesis a...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.01.007
更新日期:2018-04-01 00:00:00
abstract::Understanding how asymmetries in cellular constituents are achieved and how such positional information directs the construction of structures in a nonrandom fashion is a fundamental problem in cell biology. The recent identification of determinants that self-assemble into macromolecular complexes at the bacterial cel...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2017.11.007
更新日期:2018-04-01 00:00:00
abstract::Microbial pathogens possess a diversity of weapons that disrupt host homeostasis and immune defenses, thus resulting in the establishment of infection. The best-characterized system mediating bacterial protein delivery into target eukaryotic cells is the type III secretion system (T3SS) expressed by Gram-negative bact...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.01.010
更新日期:2018-04-01 00:00:00
abstract::Legionella pneumophila secretes over 300 effector proteins that manipulate host cells. This multiplicity of effectors hampers the characterization of their individual roles. Shames et al. report a new approach to solve the enigma of Legionella effector function by using INSeq to analyse effector functions in the conte...
journal_title:Trends in microbiology
pub_type: 评论,杂志文章
doi:10.1016/j.tim.2018.01.003
更新日期:2018-03-01 00:00:00
abstract::Phosphite, a species of phosphorus in a P3+ oxidation state, is believed to have played an important role in the primordial Earth. Figueroa et al. used metagenomics to uncover anaerobic bacterial communities from waste water waste sludge that sustain life from energy provided by phosphite. ...
journal_title:Trends in microbiology
pub_type: 评论,杂志文章
doi:10.1016/j.tim.2018.01.002
更新日期:2018-03-01 00:00:00
abstract::H3N2-subtype influenza A viruses are major causes of seasonal influenza epidemics. Emerging H3N2 variants require the annual adjustment of the vaccine strain. Recently, studies addressing the reduced effectiveness of current H3N2 vaccines have identified production-related substitutions in the viral hemagglutinin anti...
journal_title:Trends in microbiology
pub_type: 评论,杂志文章
doi:10.1016/j.tim.2017.12.003
更新日期:2018-02-01 00:00:00
abstract::Seasonal influenza is controlled through vaccination campaigns. Evolution of influenza virus antigens means that vaccines must be updated to match novel strains, and vaccine effectiveness depends on the ability of scientists to predict nearly a year in advance which influenza variants will dominate in upcoming seasons...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2017.09.004
更新日期:2018-02-01 00:00:00
abstract::Vaccines preventing seasonal influenza infections save many lives every year; however, due to rapid viral evolution, they have to be updated frequently to remain effective. To identify appropriate vaccine strains, the World Health Organization (WHO) operates a global program that continually generates and interprets s...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2017.09.001
更新日期:2018-02-01 00:00:00
abstract::The polysaccharide-rich wall, which envelopes the fungal cell, is pivotal to the maintenance of cellular integrity and for the protection of the cell from external aggressors - such as environmental fluxes and during host infection. This review considers the commonalities in the composition of the wall across the fung...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2017.05.015
更新日期:2017-12-01 00:00:00