Abstract：
:To enhance infection, enveloped viruses exploit adhesion molecules expressed on the surface of host cells. Specifically, phosphatidylserine (PS) receptors - including members of the human T cell immunoglobulin and mucin domain (TIM)-family - have gained attention for their ability to mediate the entry of many enveloped viruses. However, recent evidence that TIM-1 can restrict viral release reveals a new role for these PS receptors. Additionally, viral factors such as the HIV-1 accessory protein Nef can antagonize this antiviral activity of TIM-1 while host restriction factors such as SERINC5 can enhance it. In this review, we examine the various roles of PS receptors, specifically TIM-family proteins, and the intricate relationship between host and viral factors. Elucidating the multifunctional roles of PS receptors in virus-host interaction is important for understanding viral pathogenesis and developing novel antiviral therapeutics.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Evans JP,Liu SLdoi
10.1016/j.tim.2019.10.004subject
Has Abstractpub_date
2020-03-01 00:00:00pages
224-235issue
3eissn
0966-842Xissn
1878-4380pii
S0966-842X(19)30259-8journal_volume
28pub_type
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