The role of CpG dinucleotides in DNA vaccines.

Abstract:

:DNA vaccines can induce potent humoral and cellular immune responses without any additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within DNA vaccines are immune stimulatory and exert an essential endogenous adjuvant activity. These CpG motifs can be added deliberately to DNA or conventional protein vaccines to enhance the Th1 immune response.

journal_name

Trends Microbiol

journal_title

Trends in microbiology

authors

Krieg AM,Yi AK,Schorr J,Davis HL

doi

10.1016/S0966-842X(97)01145-1

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

23-7

issue

1

eissn

0966-842X

issn

1878-4380

pii

S0966-842X(97)01145-1

journal_volume

6

pub_type

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