Abstract：
:The use of quality control mechanisms to stall developmental pathways or completely remove defective cells from a population is a widespread strategy to ensure the integrity of morphogenetic programs. Endospore formation (sporulation) is a well conserved microbial developmental strategy in the Firmicutes phylum wherein a progenitor cell that faces starvation differentiates to form a dormant spore. Despite the conservation of this strategy, it has been unclear what selective pressure maintains the fitness of this developmental program, composed of hundreds of unique genes, during multiple rounds of vegetative growth when sporulation is not required. Recently, a quality control pathway was discovered in Bacillus subtilis which monitors the assembly of the spore envelope and specifically eliminates, through cell lysis, sporulating cells that assemble the envelope incorrectly. Here, we review the use of checkpoints that govern the entry into sporulation in B. subtilis and discuss how the use of regulated cell death pathways during bacterial development may help maintain the fidelity of the sporulation program in the species.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Decker AR,Ramamurthi KSdoi
10.1016/j.tim.2017.03.005subject
Has Abstractpub_date
2017-08-01 00:00:00pages
637-647issue
8eissn
0966-842Xissn
1878-4380pii
S0966-842X(17)30057-4journal_volume
25pub_type
杂志文章,评审abstract：:Most membrane-anchored histidine kinases (HKs) of bacterial two-component systems (2CSs) contain an extracellular input domain that is thought to be responsible for sensing an environmental cue. By contrast, intramembrane-sensing HKs (IM-HKs) lack a sensory domain and cannot perceive their stimuli directly. Instead, a...
journal_title：Trends in microbiology
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abstract：:Bacteriophages are viruses of bacteria that are used for controlling bacterial food-borne pathogens and have been proposed for more extensive usage in infection control. Protists are now recognised to harbour viruses and virus-like particles. We propose that investigation of their prevalence in parasites be intensifie...
journal_title：Trends in microbiology
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doi：10.1016/j.tim.2013.02.006
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2020.05.001
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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journal_title：Trends in microbiology
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doi：10.1016/j.tim.2006.01.003
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2003.09.004
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journal_title：Trends in microbiology
pub_type： 评论,杂志文章
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更新日期：2020-04-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2005.12.006
更新日期：2006-02-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2013.07.001
更新日期：2013-10-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/0966-842x(94)90628-9
更新日期：1994-07-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/S0966-842X(97)01005-6
更新日期：1997-04-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/j.tim.2014.09.004
更新日期：2015-01-01 00:00:00
abstract：:It is usually assumed that most prokaryotes, when given appropriate nutrients, can grow and divide in the absence of other cells of the same species. However, recent studies have suggested that, for growth, prokaryotes need to communicate with each other using signalling molecules, and a variety of 'eukaryotic' hormon...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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更新日期：2014-12-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 评论,杂志文章
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更新日期：2018-02-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2017.05.008
更新日期：2017-11-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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更新日期：2018-02-01 00:00:00
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journal_title：Trends in microbiology
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更新日期：2020-07-01 00:00:00
abstract：:The spectacular ability of Epstein-Barr virus (EBV) to immortalize and morphologically transform human B cells in vitro to lymphoblastoid cell lines (LCLs) is central to most molecular models of viral oncogenesis. However, binding of transcription factor and oncoprotein c-Myc to the major locus control region (LCR) of...
journal_title：Trends in microbiology
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更新日期：2004-11-01 00:00:00
abstract：:The actin cytoskeleton plays a key role during the replication cycle of human immunodeficiency virus-1 (HIV-1). HIV-1 infection is affected by cellular proteins that influence the clustering of viral receptors or the subcortical actin cytoskeleton. Several of these actin-adaptor proteins are controlled by the second m...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2014.03.009
更新日期：2014-07-01 00:00:00
abstract：:A new genetic locus mediating avirulence in the potato late blight pathogen Phytophthora infestans has been discovered. The Avr3b-Avr10-Avr11 locus is recognized by three different potato resistance genes, and is different from other Avr loci that have been identified thus far. This locus encodes a large protein with ...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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更新日期：2006-11-01 00:00:00
abstract：:Fluorescent amino acid analogs have proven to be useful tools for studying the dynamics of peptidoglycan metabolism. García-Heredia and colleagues showed that their route of incorporation differs depending on the adjunct fluorophore and applied this property to investigate mycobacterial peptidoglycan synthesis and rem...
journal_title：Trends in microbiology
pub_type： 评论,杂志文章
doi：10.1016/j.tim.2018.11.006
更新日期：2019-01-01 00:00:00
abstract：:Intestinal epithelial cells secrete a spectrum of chemoattractant and proinflammatory cytokines after invasion by bacteria. We suggest the novel concept that epithelial cells not only act as a mechanical barrier to invasive bacteria, but that they also signal the presence of invasive pathogens to the mucosal immune an...
journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/s0966-842x(00)88894-0
更新日期：1995-03-01 00:00:00
