Abstract：
:Bacteria use type IV secretion systems (T4SS) to translocate macromolecular substrates destined for bacterial, plant or human target cells. The T4SS are medically important, contributing to virulence-gene spread, genome plasticity and the alteration of host cellular processes during infection. The T4SS are ancestrally related to bacterial conjugation machines, but present-day functions include (i) conjugal transfer of DNA by cell-to-cell contact, (ii) translocation of effector molecules to eukaryotic target cells, and (iii) DNA uptake from or release to the extracellular milieu. Rapid progress has been made toward identification of type IV secretion substrates and the requirements for substrate recognition.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Ding Z,Atmakuri K,Christie PJdoi
10.1016/j.tim.2003.09.004subject
Has Abstractpub_date
2003-11-01 00:00:00pages
527-35issue
11eissn
0966-842Xissn
1878-4380pii
S0966842X03002609journal_volume
11pub_type
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