Abstract:
:Selected bacterial pathogens, such as Helicobacter pylori and Mycobacterium tuberculosis, establish persistent infections in mammalian hosts despite activating inflammatory and antimicrobial responses. The strategies used to overcome host defense responses vary with the anatomical location of the infection but often rely on deliberate manipulations of the host cell responses. Phylogenetically unrelated bacteria can share similar strategies for the establishment of persistence and, in selected examples, one even can define homologous "persistence" genes. Such observations suggest that persistent infection is a specific phase in infection pathogenesis rather than a fortuitous imbalance in the host-pathogen interaction.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Rhen M,Eriksson S,Clements M,Bergström S,Normark SJdoi
10.1016/s0966-842x(02)00038-0subject
Has Abstractpub_date
2003-02-01 00:00:00pages
80-6issue
2eissn
0966-842Xissn
1878-4380pii
S0966842X02000380journal_volume
11pub_type
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