Abstract：
:The global emergence of multidrug resistant Acinetobacter baumannii has reduced the number of clinically available antibiotics that retain activity against this pathogen. For this reason, the development of novel prevention and treatment strategies for infections caused by A. baumannii is necessary. Several studies have begun to characterize nonantibiotic approaches that utilize novel mechanisms of action to achieve antibacterial activity. Recent advances in phage therapy, iron chelation therapy, antimicrobial peptides, prophylactic vaccination, photodynamic therapy, and nitric oxide (NO)-based therapies have all been shown to have activity against A. baumannii. However, before these approaches can be used clinically there are still limitations and remaining questions that must be addressed.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
García-Quintanilla M,Pulido MR,López-Rojas R,Pachón J,McConnell MJdoi
10.1016/j.tim.2012.12.002subject
Has Abstractpub_date
2013-03-01 00:00:00pages
157-63issue
3eissn
0966-842Xissn
1878-4380pii
S0966-842X(12)00225-9journal_volume
21pub_type
杂志文章,评审abstract：:Pathogenic Yersinia express a complex array of iron-regulated functions and possess mechanisms for inorganic iron and hemin acquisition. These include a unique temperature-regulated hemin storage system, high-affinity transport processes for hemin and inorganic iron, and an iron-responsive regulatory system controllin...
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更新日期：2016-11-01 00:00:00
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更新日期：2003-12-01 00:00:00
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