Membrane rearrangements in fusion mediated by viral proteins.

abstract：:Rolling circle DNA replication is inherently continuous and unregulated. This 'go-for-broke' strategy works well for lytic phages but is suicidal for plasmids that must coexist with their host. Plasmids have consequently evolved elaborate copy number control systems that operate at the transcriptional, translational a...

journal_title：Trends in microbiology

authors： Rasooly A,Rasooly RS

更新日期：1997-11-01 00:00:00

abstract：:Plant root activities shape microbial community functioning in the soil, making the rhizosphere the epicenter of soil biogeochemical processes. With this opinion article, we argue to rethink the rhizosphere boundaries: as gases can diffuse several centimeters away from the roots into the soil, the portion of soil infl...

journal_title：Trends in microbiology

authors： de la Porte A,Schmidt R,Yergeau É,Constant P

更新日期：2020-07-01 00:00:00

abstract：:The cnidarian-dinoflagellate symbiosis is of huge importance as it underpins the success of coral reefs, yet we know very little about how the host cnidarian and its dinoflagellate endosymbionts communicate with each other to form a functionally integrated unit. Here, we review the current knowledge of interpartner mo...

journal_title：Trends in microbiology

authors： Rosset SL,Oakley CA,Ferrier-Pagès C,Suggett DJ,Weis VM,Davy SK

更新日期：2020-09-23 00:00:00

abstract：:Quorum sensing is a process of bacterial cell-cell communication that uses small diffusible molecules to coordinate diverse behaviors in response to population density. The only quorum-sensing system shared by Gram-positive and Gram-negative bacteria involves the production of autoinducer-2 (AI-2). The AI-2 synthase L...

journal_title：Trends in microbiology

authors： De Keersmaecker SC,Sonck K,Vanderleyden J

更新日期：2006-03-01 00:00:00

abstract：:Microbial pathogens possess a diversity of weapons that disrupt host homeostasis and immune defenses, thus resulting in the establishment of infection. The best-characterized system mediating bacterial protein delivery into target eukaryotic cells is the type III secretion system (T3SS) expressed by Gram-negative bact...

journal_title：Trends in microbiology

authors： Pinaud L,Sansonetti PJ,Phalipon A

更新日期：2018-04-01 00:00:00

abstract：:Understanding how asymmetries in cellular constituents are achieved and how such positional information directs the construction of structures in a nonrandom fashion is a fundamental problem in cell biology. The recent identification of determinants that self-assemble into macromolecular complexes at the bacterial cel...

journal_title：Trends in microbiology

authors： Bergé M,Viollier PH

更新日期：2018-04-01 00:00:00

abstract：:Increasing evidence indicates that Staphylococcus aureus might be a facultative intracellular pathogen. In particular, certain subpopulations, called small colony variants (SCVs), seem to be well adapted to the intracellular milieu. When compared to 'normal' staphylococcal strains, SCVs show increased uptake by host c...

journal_title：Trends in microbiology

authors： Sendi P,Proctor RA

更新日期：2009-02-01 00:00:00

abstract：:The Fungi comprise a diverse kingdom of eukaryotes that are characterized by a typically filamentous but sometimes unicellular vegetative form, and heterotrophic, absorptive nutrition. Their simple morphologies and variable ecological strategies have confounded efforts to elucidate their limits, phylogenetic relations...

journal_title：Trends in microbiology

authors： McLaughlin DJ,Hibbett DS,Lutzoni F,Spatafora JW,Vilgalys R

更新日期：2009-11-01 00:00:00

abstract：:DNA damage that blocks the transcription of genes is prioritized for repair by transcription-coupled DNA repair pathways. RNA polymerases stalled at DNA lesions obstruct repair enzymes, but this situation is turned to the advantage of the cell by transcription-repair coupling factors that remove the stalled RNA polyme...

journal_title：Trends in microbiology

authors： Savery NJ

更新日期：2007-07-01 00:00:00

abstract：:Subunit vaccines based on recombinant proteins can suffer from poor immunogenicity owing to incorrect folding of the target protein or poor presentation to the immune system. Virus-like particles (VLPs) represent a specific class of subunit vaccine that mimic the structure of authentic virus particles. They are recogn...

journal_title：Trends in microbiology

authors： Noad R,Roy P

更新日期：2003-09-01 00:00:00

abstract：:Antifungal drug discovery is starting to benefit from the enormous advances in the genomics field, which have occurred in the past decade. As traditional drug screening on existing targets is not delivering the long-awaited potent antifungals, efforts to use novel genetics and genomics-based strategies to aid in the d...

journal_title：Trends in microbiology

authors： De Backer MD,Van Dijck P

更新日期：2003-10-01 00:00:00

abstract：:Insect endogenous retroviruses (IERVs) are present in the genome of several species. Previous studies have shown a relationship between the envelope glycoproteins (Envs) and fusion proteins (FPs) of several baculoviruses. We used this sequence similarity to predict fusion domains in the Envs of IERVs. We suggest that ...

journal_title：Trends in microbiology

authors： Misseri Y,Labesse G,Bucheton A,Terzian C

更新日期：2003-06-01 00:00:00

abstract：:The recent observation of a surge in human monkeypox in the Democratic Republic of the Congo (DRC) prompts the question of whether cessation of smallpox vaccination is driving the phenomenon, and if so, why is re-emergence not universal throughout the historic geographic range of the virus? Research addressing the vir...

journal_title：Trends in microbiology

authors： Reynolds MG,Damon IK

更新日期：2012-02-01 00:00:00

abstract：:Deeper understanding of the bacteriostatic and bactericidal mechanisms of antimicrobial peptides (AMPs) should help in the design of new antibacterial agents. Over several decades, a variety of biochemical assays have been applied to bulk bacterial cultures. While some of these bulk assays provide time resolution of t...

journal_title：Trends in microbiology

authors： Choi H,Rangarajan N,Weisshaar JC

更新日期：2016-02-01 00:00:00

abstract：:Knockout mice with distinct gene deletions are valuable tools for in vivo analyses of the immune response against infectious agents. Studies of bacterial and protozoal infections have shown that antimicrobial immunity is generally defective in knockout mice. At one extreme, deletion of just one gene may completely com...

journal_title：Trends in microbiology

authors： Kaufmann SH,Ladel CH

更新日期：1994-07-01 00:00:00

abstract：:The bacterial flagellum is a complex self-assembling nanomachine that contains its own type III protein export apparatus. Upon completion of early flagellar structure, this apparatus switches substrate specificity to export late structural subunits, thereby coupling sequential flagellar gene expression with flagellar ...

journal_title：Trends in microbiology

authors： Ferris HU,Minamino T

更新日期：2006-12-01 00:00:00

abstract：:Intracellular pathogens customize the composition and function of the vacuoles they occupy, and can arrest or distort vacuolar maturation. In doubly infected cells, vacuoles that contain two different parasites can be used to test for exclusionary mechanisms, for expression of vacuolar phenotypes that permit or restri...

journal_title：Trends in microbiology

authors： Rabinovitch M,Veras PS

更新日期：1996-04-01 00:00:00

abstract：:Bacteria use type IV secretion systems (T4SS) to translocate macromolecular substrates destined for bacterial, plant or human target cells. The T4SS are medically important, contributing to virulence-gene spread, genome plasticity and the alteration of host cellular processes during infection. The T4SS are ancestrally...

journal_title：Trends in microbiology

authors： Ding Z,Atmakuri K,Christie PJ

更新日期：2003-11-01 00:00:00

abstract：:Fungal infections are on the rise due to new medical procedures that have increased the number of immune compromised patients, antibacterial antibiotics that disrupt the microbiome, and increased use of indwelling medical devices that provide sites for biofilm formation. Key to understanding the mechanisms of pathogen...

journal_title：Trends in microbiology

authors： Min K,Neiman AM,Konopka JB

更新日期：2020-11-01 00:00:00

abstract：:Although biologists have long recognized the importance of studying evolution to understand the organization of living organisms, only with the development of genomics have evolutionary studies become part of their routine toolkit. Placing genomes into an evolutionary framework has proved useful for understanding the ...

journal_title：Trends in microbiology

authors： Abby S,Daubin V

更新日期：2007-03-01 00:00:00

abstract：:As plastic debris in the environment continues to increase, an emerging concern is the potential for microplastic to act as vectors for pathogen transport. With aquaculture the fastest growing food sector, and microplastic contamination of shellfish increasingly demonstrated, understanding any risk of pathogen transpo...

journal_title：Trends in microbiology

authors： Bowley J,Baker-Austin C,Porter A,Hartnell R,Lewis C

更新日期：2021-02-01 00:00:00

abstract：:Cervical cancer is the third most common cancer in women with human papillomavirus (HPV) being a key etiologic factor of this devastating disease. In this article, we describe modern advances in the genomics and transcriptomics of cervical cancer that led to uncovering the key gene drivers. We also introduce, herein, ...

journal_title：Trends in microbiology

authors： Shulzhenko N,Lyng H,Sanson GF,Morgun A

更新日期：2014-06-01 00:00:00

abstract：:The existence of a peptidoglycan cell wall in chlamydiae has been debated for several years. Several studies suggest that these organisms synthesize a cell wall, but some of the components and biosynthetic machinery seem to be missing and a bona fide cell wall has yet to be described. A recent study has revealed that ...

journal_title：Trends in microbiology

authors： Pavelka MS Jr

更新日期：2007-04-01 00:00:00

abstract：:Resistance to tetracycline is generally due either to energy-dependent efflux of tetracycline or to protection of the bacterial ribosomes from the action of tetracycline. The genes that encode this resistance are normally acquired via transferable plasmids and/or transposons. Tet determinants have been found in a wide...

journal_title：Trends in microbiology

authors： Roberts MC

更新日期：1994-10-01 00:00:00

abstract：:Recent emerging evidence has revealed that regulatory noncoding RNAs (microRNAs, circular RNAs) modulate host-microbe interactions and they have been proposed as potential biomarkers of the host's response to microbiome-linked pathologies such as cancers, obesity, and neurodegenerative diseases. Interactions between m...

journal_title：Trends in microbiology

authors： Malmuthuge N,Guan LL

更新日期：2021-01-05 00:00:00

abstract：:Most membrane-anchored histidine kinases (HKs) of bacterial two-component systems (2CSs) contain an extracellular input domain that is thought to be responsible for sensing an environmental cue. By contrast, intramembrane-sensing HKs (IM-HKs) lack a sensory domain and cannot perceive their stimuli directly. Instead, a...

journal_title：Trends in microbiology

authors： Mascher T

更新日期：2014-10-01 00:00:00

abstract：:The recognition of bacterial asymmetry is not new: the first high-resolution microscopy studies revealed that bacteria come in a multitude of shapes and sometimes carry asymmetrically localized external structures such as flagella on the cell surface. Even so, the idea that bacteria could have an inherent overall pola...

journal_title：Trends in microbiology

authors： Ebersbach G,Jacobs-Wagner C

更新日期：2007-03-01 00:00:00

abstract：:Researchers now recognize the importance of the coral microbiome, but they often overlook other species that live on corals and influence coral-microbe interactions. These 'interstitial associates' should be incorporated into the metaorganism concept for insights into how facilitations between associates, corals, and ...

journal_title：Trends in microbiology

authors： Ainsworth TD,Renzi JJ,Silliman BR

更新日期：2020-08-01 00:00:00

abstract：:Viruses have evolved complex and dynamic interactions with their host cell. In recent years we have gained insight into the expanding roles for host lipids in the virus life cycle. In particular, viruses target lipid signaling, synthesis, and metabolism to remodel their host cells into an optimal environment for their...

journal_title：Trends in microbiology

authors： Heaton NS,Randall G

更新日期：2011-07-01 00:00:00

abstract：:Mycoplasmas are minute wall-less bacterial parasites that exhibit strict host and tissue specificities. They enter, multiply and survive within the host for extended periods by circumventing host defenses. Their intimate interaction with eukaryotic cells, and in some cases the subsequent invasion into or fusion with t...

journal_title：Trends in microbiology

authors： Rottem S,Naot Y

更新日期：1998-11-01 00:00:00