Abstract：
:Microbial pathogens possess a diversity of weapons that disrupt host homeostasis and immune defenses, thus resulting in the establishment of infection. The best-characterized system mediating bacterial protein delivery into target eukaryotic cells is the type III secretion system (T3SS) expressed by Gram-negative bacteria, including the human enteric pathogens Shigella, Salmonella, Yersinia, and enteropathogenic/enterohemorragic Escherichia coli (EPEC/EHEC). The emerging global view is that these T3SS-bearing pathogens share similarities in their ability to target key cellular pathways such as the cell cytoskeleton, trafficking, cell death/survival, and the NF-κB and MAPK signaling pathways. In particular, multiple host proteins are targeted in a given pathway, and different T3SS effectors from various pathogens share functional similarities.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Pinaud L,Sansonetti PJ,Phalipon Adoi
10.1016/j.tim.2018.01.010subject
Has Abstractpub_date
2018-04-01 00:00:00pages
266-283issue
4eissn
0966-842Xissn
1878-4380pii
S0966-842X(18)30022-2journal_volume
26pub_type
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