Abstract：
:Activation of innate immune signaling pathways through cytosolic RIG-I-like receptors (RLR) is a crucial response that is antagonized by many viruses. A variety of RNA-related pathogen-associated molecular patterns (PAMPS) have been identified and their role in RLR activation has been examined. Recent studies suggest that several virus-encoded components that antagonize RLR signaling interact with and inhibit the interferon (IFN)-α/β activation pathway using both RNA-dependent and RNA-independent mechanisms. The structural basis for these RLR inhibitory mechanisms, as well as the multifunctional nature of viral RLR antagonists, is reviewed in the context of recent biochemical and structural studies.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Leung DW,Basler CF,Amarasinghe GKdoi
10.1016/j.tim.2011.12.005subject
Has Abstractpub_date
2012-03-01 00:00:00pages
139-46issue
3eissn
0966-842Xissn
1878-4380pii
S0966-842X(11)00226-5journal_volume
20pub_type
杂志文章,评审abstract：:Deeper understanding of the bacteriostatic and bactericidal mechanisms of antimicrobial peptides (AMPs) should help in the design of new antibacterial agents. Over several decades, a variety of biochemical assays have been applied to bulk bacterial cultures. While some of these bulk assays provide time resolution of t...
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