Flipping the switch: bringing order to flagellar assembly.

Abstract:

:The bacterial flagellum is a complex self-assembling nanomachine that contains its own type III protein export apparatus. Upon completion of early flagellar structure, this apparatus switches substrate specificity to export late structural subunits, thereby coupling sequential flagellar gene expression with flagellar assembly. The switch is achieved by a conformational change of the export apparatus component FlhB driven by the flagellar hook-length control protein FliK. Two basic models of FliK- and FlhB-based switching are currently being pursued, together with the investigation of another factor, Flk, which prevents premature export of late substrates. Here, we review in detail each of these three export switch components and present the current understanding of how they work in concert in the making of a flagellum.

journal_name

Trends Microbiol

journal_title

Trends in microbiology

authors

Ferris HU,Minamino T

doi

10.1016/j.tim.2006.10.006

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

519-26

issue

12

eissn

0966-842X

issn

1878-4380

pii

S0966-842X(06)00252-6

journal_volume

14

pub_type

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