Abstract：
:Extracytoplasmic thiol-disulfide oxidoreductases (TDORs) catalyze the oxidation, reduction, and isomerization of protein disulfide bonds. Although these processes have been characterized in Gram-negative bacteria, the majority of Gram-positive TDORs have only recently been discovered. Results from recent studies have revealed distinct trends in the types of TDOR used by different groups of Gram-positive bacteria, and in their biological functions. Actinobacteria TDORs can be essential for viability, while Firmicute TDORs influence various physiological processes, including protein stability, oxidative stress resistance, bacteriocin production, and virulence. In this review we discuss the diverse extracytoplasmic TDORs used by Gram-positive bacteria, with a focus on Gram-positive Firmicutes.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Davey L,Halperin SA,Lee SFdoi
10.1016/j.tim.2016.06.010subject
Has Abstractpub_date
2016-11-01 00:00:00pages
902-915issue
11eissn
0966-842Xissn
1878-4380pii
S0966-842X(16)30073-7journal_volume
24pub_type
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