Abstract：
:Fungal infections are on the rise due to new medical procedures that have increased the number of immune compromised patients, antibacterial antibiotics that disrupt the microbiome, and increased use of indwelling medical devices that provide sites for biofilm formation. Key to understanding the mechanisms of pathogenesis is to determine how fungal morphology impacts virulence strategies. For example, small budding cells use very different strategies to disseminate compared with long hyphal filaments. Furthermore, cell morphology must be monitored in the host, as many fungal pathogens change their shape to disseminate into new areas, acquire nutrients, and avoid attack by the immune system. This review describes the shape-shifting alterations in morphogenesis of human fungal pathogens and how they influence virulence strategies.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Min K,Neiman AM,Konopka JBdoi
10.1016/j.tim.2020.05.001subject
Has Abstractpub_date
2020-11-01 00:00:00pages
922-933issue
11eissn
0966-842Xissn
1878-4380pii
S0966-842X(20)30126-8journal_volume
28pub_type
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