Abstract:
:In bacteria, Ca(2+) is implicated in a wide variety of cellular processes, including the cell cycle and cell division. Dedicated influx and efflux systems tightly control the low cytoplasmic Ca(2+) levels in prokaryotes. Additionally, the growing number of proteins containing various Ca(2+)-binding motifs supports the importance of Ca(2+), which controls various protein functions by affecting protein stability, enzymatic activity or signal transduction. The existence of calmodulin-like proteins (containing EF-hand motifs) in bacteria is a long-standing hypothesis. Analysis of the prokaryotic protein sequences available in the databases has revealed the presence of several calmodulin-like proteins containing two or more authentic EF-hand motifs, suggesting that calmodulin-like proteins could be involved in Ca(2+) regulation in bacteria.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Michiels J,Xi C,Verhaert J,Vanderleyden Jdoi
10.1016/s0966-842x(01)02284-3subject
Has Abstractpub_date
2002-02-01 00:00:00pages
87-93issue
2eissn
0966-842Xissn
1878-4380pii
S0966842X01022843journal_volume
10pub_type
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