Abstract:
:Staphylococcus aureus and Staphylococcus epidermidis are a frequent cause of biofilm-associated infections that are a tremendous burden on our healthcare system. Staphylococcal biofilms exhibit extraordinary resistance to antimicrobial killing, limiting the efficacy of antibiotic therapy, and surgical intervention is often required to remove infected tissues or implanted devices. Recent work has provided new insight into the molecular basis of biofilm development in these opportunistic pathogens. Extracellular bacterial products, environmental conditions, and polymicrobial interactions have all been shown to influence profoundly the ability of these bacteria to colonize and disperse from clinically relevant surfaces. We review new developments in staphylococcal biofilm disassembly and set them in the context of potential strategies to control biofilm infections.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Boles BR,Horswill ARdoi
10.1016/j.tim.2011.06.004subject
Has Abstractpub_date
2011-09-01 00:00:00pages
449-55issue
9eissn
0966-842Xissn
1878-4380pii
S0966-842X(11)00125-9journal_volume
19pub_type
杂志文章,评审abstract::The assembly of microbial communities within the gastrointestinal tract during early life plays a critical role in immune, endocrine, metabolic, and other host developmental pathways. Environmental insults during this period, such as food insecurity and infections, can disrupt this optimal microbial succession, which ...
journal_title:Trends in microbiology
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abstract::Several features of HIV have frustrated efforts to develop a vaccine able to induce broadly neutralising antibodies. The enormous genetic diversity of HIV is a major factor, accompanied by the camouflaged nature of the envelope spike, upon which HIV depends for cellular entry and to which antibodies must bind to neutr...
journal_title:Trends in microbiology
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abstract::The susceptibility of Caenorhabditis elegans to different virulent phenotypes of Pseudomonas aeruginosa makes the worms an excellent model for studying host-pathogen interactions. Including the recently described liquid killing, five different killing assays are now available offering superb possibilities for performi...
journal_title:Trends in microbiology
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abstract::Key skills such as communication and critical thinking are essential for today's microbiology graduate. There are many opportunities within the undergraduate curriculum to help students to use, develop and appreciate their own unique set of skills. This article describes personal experiences of research-led teaching a...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2009.12.006
更新日期:2010-02-01 00:00:00
abstract::Most cases of candidiasis have been attributed to Candida albicans, but Candida glabrata, Candida parapsilosis and Candida tropicalis, designated as non-C. albicans Candida (NCAC), have been identified as frequent human pathogens. Moreover, Candida biofilms are an escalating clinical problem associated with significan...
journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2011.05.002
更新日期:2011-09-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2006.02.009
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2013.08.001
更新日期:2013-11-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(01)02284-3
更新日期:2002-02-01 00:00:00
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journal_title:Trends in microbiology
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更新日期:2021-01-19 00:00:00
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journal_title:Trends in microbiology
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doi:10.1016/s0966-842x(02)00003-3
更新日期:2003-01-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.11.011
更新日期:2019-05-01 00:00:00
abstract::CRISPR (clustered regularly interspaced short palindromic repeats)-based immune systems are essentially modular with three primary functions: the excision and integration of new spacers, the processing of CRISPR transcripts to yield mature CRISPR RNAs (crRNAs), and the targeting and cleavage of foreign nucleic acid. T...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2011.08.002
更新日期:2011-11-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2006.10.003
更新日期:2006-12-01 00:00:00
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
pub_type: 评论,杂志文章
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更新日期:2018-03-01 00:00:00
abstract::Bacterial motility relies chiefly on the rotation of a molecular propeller, the flagellar filament, which is constructed from the protein flagellin. Here, flagellin sequence conservation and diversity is examined in the light of the recently determined flagellar filament structure. As expected, the surface-exposed dom...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2006.02.008
更新日期:2006-04-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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更新日期:1997-05-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2005.02.006
更新日期:2005-04-01 00:00:00
abstract::Microbial rhodopsins are the photoreceptive membrane proteins found in diverse microorganisms from within Archaea, Eubacteria, and eukaryotes. They have a hep-tahelical transmembrane structure that binds to an all-trans retinal chromophore. Since 2000, thousands of proteorhodopsins, genes of light-driven proton pump r...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2014.10.009
更新日期:2015-02-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2011.03.007
更新日期:2011-07-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2012.12.002
更新日期:2013-03-01 00:00:00
abstract::The evolution of virulence in Salmonella is driven by horizontal gene transfer. This has given rise to highly flexible pathogens that are able to colonize new niches and extend their host range. Tracing the record of horizontal gene transfer can provide clues to the virulence factors that contribute to the formation o...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/S0966-842X(97)01082-2
更新日期:1997-08-01 00:00:00