Abstract：
:Progress in understanding the evolution of infectious diseases has inspired proposals to manage the evolution of pathogen (including parasite) virulence. A common view is that social interventions that lower pathogen transmission will indirectly select lower virulence because of a trade-off between transmission and virulence. Here, we argue that there is little theoretical justification and no empirical evidence for this plan. Although a trade-off model might apply to some pathogens, the mechanism appears too weak for rapid selection of substantial changes in virulence. Direct selection against virulence itself might be a more rewarding approach to managing the evolution of virulence.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Ebert D,Bull JJdoi
10.1016/s0966-842x(02)00003-3subject
Has Abstractpub_date
2003-01-01 00:00:00pages
15-20issue
1eissn
0966-842Xissn
1878-4380pii
S0966842X02000033journal_volume
11pub_type
杂志文章abstract：:Despite the fact that dengue is one of the most prevalent viral infections of humans, the mechanisms responsible for its pathogenesis remain uncertain. Evolutionary studies of dengue virus have revealed that its genetic diversity is increasing. This, coupled with evidence that viral strains could naturally differ in v...
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
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