Abstract：
:CRISPR (clustered regularly interspaced short palindromic repeats)-based immune systems are essentially modular with three primary functions: the excision and integration of new spacers, the processing of CRISPR transcripts to yield mature CRISPR RNAs (crRNAs), and the targeting and cleavage of foreign nucleic acid. The primary target appears to be the DNA of foreign genetic elements, but the CRISPR/Cmr system that is widespread amongst archaea also specifically targets and cleaves RNA in vitro. The archaeal CRISPR systems tend to be both diverse and complex. Here we examine evidence for exchange of functional modules between archaeal systems that is likely to contribute to their diversity, particularly of their nucleic acid targeting and cleavage functions. The molecular constraints that limit such exchange are considered. We also summarize mechanisms underlying the dynamic nature of CRISPR loci and the evidence for intergenomic exchange of CRISPR systems.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Garrett RA,Vestergaard G,Shah SAdoi
10.1016/j.tim.2011.08.002subject
Has Abstractpub_date
2011-11-01 00:00:00pages
549-56issue
11eissn
0966-842Xissn
1878-4380pii
S0966-842X(11)00149-1journal_volume
19pub_type
杂志文章,评审abstract：:Bacterial motility relies chiefly on the rotation of a molecular propeller, the flagellar filament, which is constructed from the protein flagellin. Here, flagellin sequence conservation and diversity is examined in the light of the recently determined flagellar filament structure. As expected, the surface-exposed dom...
journal_title：Trends in microbiology
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abstract：:Corynebacterium glutamicum, a Gram-positive soil bacterium, is used for the production of l-glutamate and l-lysine, both of which are derived from intermediates of the tricarboxylic acid (TCA) cycle. Recent studies have revealed that this amphibolic pathway is subject to complex regulation not only at the transcriptio...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2006.09.004
更新日期：2006-11-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
pub_type： 评论,杂志文章
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
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更新日期：2020-07-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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更新日期：2012-06-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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更新日期：2018-02-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 评论,杂志文章
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/0966-842x(94)90004-3
更新日期：1994-08-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2019.06.007
更新日期：2019-11-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/j.tim.2006.02.001
更新日期：2006-04-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/j.tim.2007.10.003
更新日期：2007-11-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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pub_type： 新闻
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
pub_type： 评论,杂志文章
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
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更新日期：2008-09-01 00:00:00
abstract：:Protozoans of the genus Plasmodium are the causative agents of malaria; they have a complex life cycle involving vertebrate and arthropod hosts and have three distinct invasive stages. Although the invasive stages probably invade cells using similar mechanisms, each stage has a different host cell specificity and util...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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abstract：:Invasive fungal infections are a major cause of mortality in immunocompromised patients. By using high-resolution sequencing, Zhai et al. provide insight into translocation of Candida strains from the gut mycobiota to the bloodstream of transplanted patients. Microbiota-driven diagnostic methods could rapidly emerge f...
journal_title：Trends in microbiology
pub_type： 评论,杂志文章
doi：10.1016/j.tim.2020.01.007
更新日期：2020-04-01 00:00:00
