Abstract:
:Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that infects 10 million people worldwide and kills 2 million people every year. The uptake and utilization of nutrients by Mtb within the host cell is still poorly understood, although lipids play an important role in Mtb persistence. The recent identification of a large regulon of cholesterol catabolic genes suggests that Mtb can use host sterol for infection and persistence. In this review, we report on recent progress in elucidation of the Mtb cholesterol catabolic reactions and their potential utility as targets for tuberculosis therapeutic agents.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Ouellet H,Johnston JB,de Montellano PRdoi
10.1016/j.tim.2011.07.009subject
Has Abstractpub_date
2011-11-01 00:00:00pages
530-9issue
11eissn
0966-842Xissn
1878-4380pii
S0966-842X(11)00146-6journal_volume
19pub_type
杂志文章,评审abstract::The identification and quantification of the proteins that a whole organism expresses under certain conditions is a main focus of high-throughput proteomics. Advanced proteomics approaches generate new biologically relevant data and potent hypotheses. A practical report of what proteome studies can and cannot accompli...
journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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abstract::Fungi are an important constituent of microbial endolithic assemblages in marine ecosystems. As euendoliths, they penetrate limestone, mollusk shells and other carbonate substrates, where they can exploit mineralized organic matter, attack their hosts, or engage in symbiotic relationships. They leave specific boring t...
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journal_title:Trends in microbiology
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abstract::Genome analyses of double strand DNA tailed bacteriophages argue that they evolve by recombinational reassortment of genes and by the acquisition of novel genes as simple genetic elements termed morons. These processes suggest a model for early virus evolution, wherein viruses can be regarded less as having derived fr...
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
pub_type: 杂志文章
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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doi:10.1016/j.tim.2018.01.007
更新日期:2018-04-01 00:00:00
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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abstract::Initial hepatitis B virus (HBV) attachment occurs via heparan sulfate proteoglycans (HSPGs), which then trigger receptor-mediated internalization. Although HSPGs express in many tissues, HBV is destined for hepatotropic infection. A recent paper by Seitz et al. proposed that the slow viral maturation process plays a c...
journal_title:Trends in microbiology
pub_type: 评论,杂志文章
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