Abstract：
:The dramatic clinical manifestations of toxigenic infections such as cholera and diphtheria occur without substantial bacterial invasion. Disease is mediated by the secretion of potent toxins that use ADP-ribosylation as the catalytic mechanism underlying their action. ADP-ribosylating toxins comprise a large family, including the cholera, diphtheria, pertussis and Escherichia coli heat-labile (LT) toxins, and all produce disease by altering key metabolic processes after transfer of an ADP-ribose moiety from NAD to specific host-cell target proteins. A new paradigm implicating ADP-ribosylation during intracellular pathogenesis is beginning to emerge from recent research in Salmonella.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Lesnick ML,Guiney DGdoi
10.1016/s0966-842x(00)01902-8subject
Has Abstractpub_date
2001-01-01 00:00:00pages
2-4; discussion 4-5issue
1eissn
0966-842Xissn
1878-4380pii
S0966-842X(00)01902-8journal_volume
9pub_type
杂志文章,评审abstract：:Type III secretion (T3S) is a mechanism that is central to the biology of the Chlamydiaceae and many other pathogens whose virulence depends on the translocation of toxic effector proteins to cytosolic targets within infected eukaryotic cells. Biomathematical simulations, using a previously described model of contact-...
journal_title：Trends in microbiology
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journal_title：Trends in microbiology
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doi：10.1016/j.tim.2007.01.007
更新日期：2007-03-01 00:00:00
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
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doi：10.1016/j.tim.2019.04.005
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journal_title：Trends in microbiology
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更新日期：1995-03-01 00:00:00
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
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更新日期：2012-12-01 00:00:00
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journal_title：Trends in microbiology
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doi：10.1016/j.tim.2006.10.003
更新日期：2006-12-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2017.05.008
更新日期：2017-11-01 00:00:00
abstract：:The spectacular ability of Epstein-Barr virus (EBV) to immortalize and morphologically transform human B cells in vitro to lymphoblastoid cell lines (LCLs) is central to most molecular models of viral oncogenesis. However, binding of transcription factor and oncoprotein c-Myc to the major locus control region (LCR) of...
journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/j.tim.2004.09.006
更新日期：2004-11-01 00:00:00
abstract：:Fungal infections are on the rise due to new medical procedures that have increased the number of immune compromised patients, antibacterial antibiotics that disrupt the microbiome, and increased use of indwelling medical devices that provide sites for biofilm formation. Key to understanding the mechanisms of pathogen...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2020.05.001
更新日期：2020-11-01 00:00:00
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journal_title：Trends in microbiology
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abstract：:Oncogenic viruses have evolved direct and indirect mechanisms to overcome the tumour suppressor p53. Fortunately, tumour development is limited by the narrow cell tropisms of the viruses concerned and the host immune response. However, such viruses are helping to elucidate the p53 response pathway and may play a futur...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/S0966-842X(96)10083-4
更新日期：1997-03-01 00:00:00
abstract：:The identification and quantification of the proteins that a whole organism expresses under certain conditions is a main focus of high-throughput proteomics. Advanced proteomics approaches generate new biologically relevant data and potent hypotheses. A practical report of what proteome studies can and cannot accompli...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2006.03.005
更新日期：2006-05-01 00:00:00
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journal_title：Trends in microbiology
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doi：10.1016/0966-842x(94)90610-6
更新日期：1994-10-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2007.03.005
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journal_title：Trends in microbiology
pub_type： 评论,杂志文章
doi：10.1016/j.tim.2020.10.002
更新日期：2020-12-01 00:00:00
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journal_title：Trends in microbiology
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更新日期：2011-11-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2013.07.001
更新日期：2013-10-01 00:00:00
abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is an exogenous retrovirus that persists lifelong in the infected host. Infection has been linked to a spectrum of diverse diseases: adult T cell leukemia, encephalomyelopathy, and predisposition to opportunistic bacterial and helminth infections. Applications of new technolo...
journal_title：Trends in microbiology
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更新日期：2012-10-01 00:00:00
abstract：:During the past few decades, increasing attention has focused on pathogenic fungi both as fascinating research subjects and as the agents of serious illness in diverse patient populations. In particular, opportunistic fungi such as Cryptococcus neoformans command notice as the ranks of their immunocompromised victims ...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/s0966-842x(00)01890-4
更新日期：2000-12-01 00:00:00
abstract：:The recent availability of extensive metagenomic sequences from various environmental microbial communities has extended the postgenomic era to the field of environmental microbiology. Although still restricted to a small number of studies, metaproteomic investigations have revealed interesting aspects of functional g...
journal_title：Trends in microbiology
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doi：10.1016/j.tim.2005.12.006
更新日期：2006-02-01 00:00:00
abstract：:Some viruses have the ability to modulate the development of autoimmune diseases. Virus infections have long been associated with the exacerbation of autoimmune disease, however, there is also evidence that viruses can actually protect against autoimmune disease. Several experimental models have been developed to inve...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/s0966-842x(01)02097-2
更新日期：2001-08-01 00:00:00
abstract：:Measles virus gene expression is attenuated in neural cells by mechanisms that affect both viral transcription and translation. Host enzymes that hypermutate viral genes, and those induced by cytokines, may act cooperatively to slow viral replication and to favor persistent measles virus infections in the human centra...
journal_title：Trends in microbiology
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doi：10.1016/s0966-842x(00)88976-3
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abstract：:Corynebacterium glutamicum, a Gram-positive soil bacterium, is used for the production of l-glutamate and l-lysine, both of which are derived from intermediates of the tricarboxylic acid (TCA) cycle. Recent studies have revealed that this amphibolic pathway is subject to complex regulation not only at the transcriptio...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2007.08.004
更新日期：2007-09-01 00:00:00
