Building Walls: Work That Never Ends.


:Fluorescent amino acid analogs have proven to be useful tools for studying the dynamics of peptidoglycan metabolism. García-Heredia and colleagues showed that their route of incorporation differs depending on the adjunct fluorophore and applied this property to investigate mycobacterial peptidoglycan synthesis and remodeling with heightened granularity.


Trends Microbiol


Trends in microbiology


Botella H,Vaubourgeix J




Has Abstract


2019-01-01 00:00:00














  • RTX Adhesins are Key Bacterial Surface Megaproteins in the Formation of Biofilms.

    abstract::Gram-negative bacteria produce repeats-in-toxin adhesion proteins (RTX adhesins) to facilitate microbial adhesion. These large, multidomain proteins share a common architecture comprised of four regions. First to emerge from the bacterium, C terminal end leading, is the RTX export sequence that directs the protein thr...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Guo S,Vance TDR,Stevens CA,Voets I,Davies PL

    更新日期:2019-05-01 00:00:00

  • New and Improved Techniques for the Study of Pathogenic Fungi.

    abstract::Fungal pathogens pose serious threats to human, plant, and ecosystem health. Improved diagnostics and antifungal strategies are therefore urgently required. Here, we review recent developments in online bioinformatic tools and associated interactive data archives, which enable sophisticated comparative genomics and fu...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Cairns TC,Studholme DJ,Talbot NJ,Haynes K

    更新日期:2016-01-01 00:00:00

  • Effector-triggered immunity by the plant pathogen Phytophthora.

    abstract::A new genetic locus mediating avirulence in the potato late blight pathogen Phytophthora infestans has been discovered. The Avr3b-Avr10-Avr11 locus is recognized by three different potato resistance genes, and is different from other Avr loci that have been identified thus far. This locus encodes a large protein with ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Qutob D,Tedman-Jones J,Gijzen M

    更新日期:2006-11-01 00:00:00

  • Bacterial (intramembrane-sensing) histidine kinases: signal transfer rather than stimulus perception.

    abstract::Most membrane-anchored histidine kinases (HKs) of bacterial two-component systems (2CSs) contain an extracellular input domain that is thought to be responsible for sensing an environmental cue. By contrast, intramembrane-sensing HKs (IM-HKs) lack a sensory domain and cannot perceive their stimuli directly. Instead, a...

    journal_title:Trends in microbiology

    pub_type: 杂志文章


    authors: Mascher T

    更新日期:2014-10-01 00:00:00

  • Exploring the inner membrane proteome of Escherichia coli: which proteins are eluding detection and why?

    abstract::Proteins embedded in membranes are important for helping the cell adapt to changes in the extracellular milieu and often play key roles in the life cycles of pathogenic microbes. Bioinformatic predictions can provide an estimate of membrane proteins, but experimental approaches of detection are required for a deeper u...

    journal_title:Trends in microbiology

    pub_type: 杂志文章


    authors: Bernsel A,Daley DO

    更新日期:2009-10-01 00:00:00

  • The Pathogen-Host Interface in Three Dimensions: Correlative FIB/SEM Applications.

    abstract::Pathogens survive and propagate within host cells through a wide array of complex interactions. Tracking the molecular and cellular events by multidimensional fluorescence microscopy has been a widespread tool for research on intracellular pathogens. Through major advancements in 3D electron microscopy, intracellular ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Weiner A,Enninga J

    更新日期:2019-05-01 00:00:00

  • Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways.

    abstract::The airways of patients afflicted with cystic fibrosis (CF) are colonized by many pathogens, the most predominant of which is the Gram-negative bacterium Pseudomonas aeruginosa. In the thick CF airway mucus, P. aeruginosa forms antibiotic- and phagocyte-resistant structures known as biofilms, which enable the survival...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Hassett DJ,Sutton MD,Schurr MJ,Herr AB,Caldwell CC,Matu JO

    更新日期:2009-03-01 00:00:00

  • Candida albicans hyphal initiation and elongation.

    abstract::The fungus Candida albicans is a benign member of the mucosal microbiota, but can cause mucosal infections and life-threatening disseminated invasive infections in susceptible individuals. The ability to switch between yeast, pseudohyphal, and hyphal growth forms (polymorphism) is one of the most investigated virulenc...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Lu Y,Su C,Liu H

    更新日期:2014-12-01 00:00:00

  • Protein identification and expression analysis using mass spectrometry.

    abstract::The identification and quantification of the proteins that a whole organism expresses under certain conditions is a main focus of high-throughput proteomics. Advanced proteomics approaches generate new biologically relevant data and potent hypotheses. A practical report of what proteome studies can and cannot accompli...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Kolker E,Higdon R,Hogan JM

    更新日期:2006-05-01 00:00:00

  • Exhaustion and Inflation at Antipodes of T Cell Responses to Chronic Virus Infection.

    abstract::Viruses that have coevolved with their host establish chronic infections that are well tolerated by the host. Other viruses, that are partly adapted to their host, may induce chronic infections where persistent replication and viral antigen expression occur. The former induce highly functional and resilient CD8T cell ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Cicin-Sain L,Arens R

    更新日期:2018-06-01 00:00:00

  • Global analysis of a bacterial cell cycle: tracking down necessary functions and their regulators.

    abstract::New, post-genomic analyses are increasing the rate at which information about highly complex processes such as bacterial growth and development can be acquired. The recent use of DNA-microarray and proteomic analysis to study the differentiating bacterium Caulobacter crescentus has provided the first global view of th...

    journal_title:Trends in microbiology

    pub_type: 新闻


    authors: Brun YV

    更新日期:2001-09-01 00:00:00

  • Detecting virulence and drug-resistance mycobacterial phenotypes in vivo.

    abstract::Bacterial phenotypes are predominantly studied in culture because detection of their specific metabolic pathways in the host is challenging. Development of stable-isotope breath tests, allowing in situ phenotype analyses, may endow diagnostics with new modalities based upon direct monitoring of in vivo microbial metab...

    journal_title:Trends in microbiology

    pub_type: 杂志文章


    authors: Timmins GS

    更新日期:2015-06-01 00:00:00

  • Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections.

    abstract::Pseudomonas aeruginosa (PA) uses several virulence factors to establish chronic respiratory infections in bronchiectasis, chronic obstructive pulmonary disease, and cystic fibrosis (CF) patients. One of its toxins, pyocyanin (PYO), is a redox-active pigment that is required for full virulence in animal models and has ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Rada B,Leto TL

    更新日期:2013-02-01 00:00:00

  • Vaccination in pulses: a strategy for global eradication of measles and polio?

    abstract::Recent American successes against poliomyelitis and measles have been attributed to repeated 'pulse' vaccination campaigns. Whilst logistic and economic constraints will be crucial, a deeper epidemiological understanding of the mechanism, strengths and weaknesses of pulse vaccination will optimize the chances of succe...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Nokes DJ,Swinton J

    更新日期:1997-01-01 00:00:00

  • Prospects for new vaccines against tuberculosis.

    abstract::The spectacular failure of the existing bacille Calmette-Guérin (BCG) vaccine in recent tuberculosis-control trials has prompted a search for potential replacements. Imaginative approaches currently under development include the modulation of BCG by the production of auxotrophic mutants or cytokine-secreting recombina...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Orme IM

    更新日期:1995-10-01 00:00:00

  • What did Darwin say about microbes, and how did microbiology respond?

    abstract::Although it is commonly assumed that Darwin had nothing to say about microbes, he did in fact say quite a lot. He included microbes in his Beagle studies of the geographical distribution of organisms and used microscopic organisms as explicit exemplars of how adaptation did not imply increasing complexity. Darwin ofte...

    journal_title:Trends in microbiology

    pub_type: 历史文章,杂志文章


    authors: O'Malley MA

    更新日期:2009-08-01 00:00:00

  • The Molecular Language of the Cnidarian-Dinoflagellate Symbiosis.

    abstract::The cnidarian-dinoflagellate symbiosis is of huge importance as it underpins the success of coral reefs, yet we know very little about how the host cnidarian and its dinoflagellate endosymbionts communicate with each other to form a functionally integrated unit. Here, we review the current knowledge of interpartner mo...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Rosset SL,Oakley CA,Ferrier-Pagès C,Suggett DJ,Weis VM,Davy SK

    更新日期:2020-09-23 00:00:00

  • Maximum shields: the assembly and function of the bacterial spore coat.

    abstract::Spores produced by bacilli and clostridia are surrounded by a multilayered protein shell called the coat. As the armor-like appearance of the coat suggests, this structure, along with others within the spore, confers the remarkable resistance properties that make Bacillus anthracis spores such potent biological weapon...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Driks A

    更新日期:2002-06-01 00:00:00

  • Horizontal Gene Transfer and Ecosystem Function Dynamics.

    abstract::Horizontal gene transfer can provide bacteria with new functions that confer an important competitive advantage, and is therefore likely to affect the dynamics of bacterial ecosystems. Two studies by Wolfe et al. and Bonham et al. prepare the way to study this hypothesis in a model ecosystem with reproducible properti...

    journal_title:Trends in microbiology

    pub_type: 评论,杂志文章


    authors: van de Guchte M

    更新日期:2017-09-01 00:00:00

  • Microbial endocrinology: how stress influences susceptibility to infection.

    abstract::A holistic approach to understanding the mechanisms by which stress influences the pathogenesis of infectious disease has resulted in the development of the field of microbial endocrinology. This transdisciplinary field represents the intersection of microbiology with mammalian endocrinology and neurophysiology, and i...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Freestone PP,Sandrini SM,Haigh RD,Lyte M

    更新日期:2008-02-01 00:00:00

  • A role for systems epidemiology in tuberculosis research.

    abstract::Despite being a curable disease, tuberculosis (TB) killed more people in 2009 than during any previous year in history. Progress in TB research has been slow, and remains burdened by important gaps in our knowledge of the basic biology of Mycobacterium tuberculosis, the causative agent of TB, and its interaction with ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Comas I,Gagneux S

    更新日期:2011-10-01 00:00:00

  • From Theory to Practice: Translating Whole-Genome Sequencing (WGS) into the Clinic.

    abstract::Hospitals worldwide are facing an increasing incidence of hard-to-treat infections. Limiting infections and providing patients with optimal drug regimens require timely strain identification as well as virulence and drug-resistance profiling. Additionally, prophylactic interventions based on the identification of envi...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Balloux F,Brønstad Brynildsrud O,van Dorp L,Shaw LP,Chen H,Harris KA,Wang H,Eldholm V

    更新日期:2018-12-01 00:00:00

  • The role of CpG dinucleotides in DNA vaccines.

    abstract::DNA vaccines can induce potent humoral and cellular immune responses without any additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within DNA vaccines are immune stimulatory and exert an essential endogenous adjuvant activity. These CpG motifs can be added deliberately to DNA or conventi...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Krieg AM,Yi AK,Schorr J,Davis HL

    更新日期:1998-01-01 00:00:00

  • The role of bacterial phytotoxins in inhibiting the eukaryotic proteasome.

    abstract::The ubiquitin-26S proteasome degradation system (UPS) plays a pivotal role in almost all aspects of plant life, including defending against pathogens. Although the proteasome is important for plant immunity, it has been found to be also exploited by pathogens using effectors to increase their virulence. Recent work on...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Dudler R

    更新日期:2014-01-01 00:00:00

  • Roles of Thermokarst Lakes in a Warming World.

    abstract::Permafrost covers a quarter of the northern hemisphere land surface and contains twice the amount of carbon that is currently present in the atmosphere. Future climate change is expected to reduce its near-surface cover by over 90% by the end of the 21st century, leading to thermokarst lake formation. Thermokarst lake...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: In 't Zandt MH,Liebner S,Welte CU

    更新日期:2020-09-01 00:00:00

  • Science denial: a guide for scientists.

    abstract::Evolution, climate change, and vaccination: in these cases and more, scientists, policymakers, and educators are confronted by organized campaigns to spread doubt, denial, and rejection of the scientific community's consensus on central scientific principles. To overcome these threats, scientists not only need to spre...

    journal_title:Trends in microbiology

    pub_type: 杂志文章


    authors: Rosenau J

    更新日期:2012-12-01 00:00:00

  • Positive Interactions in the Coral Macro and Microbiome.

    abstract::Researchers now recognize the importance of the coral microbiome, but they often overlook other species that live on corals and influence coral-microbe interactions. These 'interstitial associates' should be incorporated into the metaorganism concept for insights into how facilitations between associates, corals, and ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章


    authors: Ainsworth TD,Renzi JJ,Silliman BR

    更新日期:2020-08-01 00:00:00

  • Comparative sequence analysis and predictions for the envelope glycoproteins of insect endogenous retroviruses.

    abstract::Insect endogenous retroviruses (IERVs) are present in the genome of several species. Previous studies have shown a relationship between the envelope glycoproteins (Envs) and fusion proteins (FPs) of several baculoviruses. We used this sequence similarity to predict fusion domains in the Envs of IERVs. We suggest that ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章


    authors: Misseri Y,Labesse G,Bucheton A,Terzian C

    更新日期:2003-06-01 00:00:00

  • Fleas and smaller fleas: virotherapy for parasite infections.

    abstract::Bacteriophages are viruses of bacteria that are used for controlling bacterial food-borne pathogens and have been proposed for more extensive usage in infection control. Protists are now recognised to harbour viruses and virus-like particles. We propose that investigation of their prevalence in parasites be intensifie...

    journal_title:Trends in microbiology

    pub_type: 杂志文章


    authors: Hyman P,Atterbury R,Barrow P

    更新日期:2013-05-01 00:00:00

  • Processing and export of peptide pheromones and bacteriocins in Gram-negative bacteria.

    abstract::Cell-density-dependent gene expression is widespread in bacteria and is mediated by extracellular communication molecules. Gram-negative bacteria often use N-acyl homoserine lactones, whereas cell-cell signaling in Gram-positive bacteria is accomplished using post-translationally processed peptide pheromones. In many ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Michiels J,Dirix G,Vanderleyden J,Xi C

    更新日期:2001-04-01 00:00:00