Abstract：
:Most membrane-anchored histidine kinases (HKs) of bacterial two-component systems (2CSs) contain an extracellular input domain that is thought to be responsible for sensing an environmental cue. By contrast, intramembrane-sensing HKs (IM-HKs) lack a sensory domain and cannot perceive their stimuli directly. Instead, an N-terminal signal transfer region, consisting solely of two transmembrane helices, presumably connects the IM-HKs with accessory membrane proteins that function as the true sensors. This intermolecular signal transfer, in combination with intramolecular signal conversion, provides HKs with versatile signaling relays to connect, integrate, and amplify external signals from different sensory inputs ultimately to modulate the activity of the corresponding kinase domain.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Mascher Tdoi
10.1016/j.tim.2014.05.006subject
Has Abstractpub_date
2014-10-01 00:00:00pages
559-65issue
10eissn
0966-842Xissn
1878-4380pii
S0966-842X(14)00115-2journal_volume
22pub_type
杂志文章abstract：:Improved fluorescence techniques for visualizing proteins in whole bacterial cells have resulted in recent breakthroughs in our understanding of chromosome segregation and cytokinesis in prokaryotes. The dynamics and localization of some of these proteins reveal surprisingly cytoskeletal-like behavior. ...
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journal_title：Trends in microbiology
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