Abstract:
:The nematode Caenorhabditis elegans is emerging as a facile and economical model host for the study of evolutionarily conserved mechanisms of microbial pathogenesis and innate immunity. A rapidly growing number of human and animal microbial pathogens have been shown to injure and kill nematodes. In many cases, microbial genes known to be important for full virulence in mammalian models have been shown to be similarly required for maximum pathogenicity in nematodes. C. elegans has been used in mutation-based screening systems to identify novel virulence-related microbial genes and immune-related host genes, many of which have been validated in mammalian models of disease. C. elegans-based pathogenesis systems hold the potential to simultaneously explore the molecular genetic determinants of both pathogen virulence and host defense.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Sifri CD,Begun J,Ausubel FMdoi
10.1016/j.tim.2005.01.003subject
Has Abstractpub_date
2005-03-01 00:00:00pages
119-27issue
3eissn
0966-842Xissn
1878-4380pii
S0966-842X(05)00025-9journal_volume
13pub_type
杂志文章,评审abstract::Microbial fuel cells (MFCs) are not yet commercialized but they show great promise as a method of water treatment and as power sources for environmental sensors. The power produced by these systems is currently limited, primarily by high internal (ohmic) resistance. However, improvements in the system architecture wil...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2006.10.003
更新日期:2006-12-01 00:00:00
abstract::ISG15 is an interferon (IFN)-induced ubiquitin-like protein that is conjugated to target proteins via the sequential action of three enzymes that are also induced by IFN. Unlike ubiquitin, which is highly conserved, the sequence of ISG15 varies between species. ISG15 conjugation inhibits many viruses, and free (unconj...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2013.01.005
更新日期:2013-04-01 00:00:00
abstract::Phloem transport of endogenous macromolecules and plant viruses remains poorly understood. Selective movement into and out of the phloem is tightly regulated, yet the mechanisms governing this selectivity have not been elucidated. Recent advances in identifying nonviral proteins and nucleic acids with the capacity for...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(99)01508-5
更新日期:1999-06-01 00:00:00
abstract::Viruses of the Mononegavirales have helical nucleocapsids containing a single-stranded negative-sense RNA genome complexed with the nucleoprotein and several other virus-encoded proteins. This RNA-protein complex acts as the template for replication and transcription during infection. Recent structural data has advanc...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2013.08.001
更新日期:2013-11-01 00:00:00
abstract::The endogenous circadian clock of the cyanobacterium Synechococcus elongatus controls many cellular processes and confers an adaptive advantage on this organism in a competitive environment. To be advantageous, this internal biological oscillator must be reset daily to remain in synchrony with its environment and to t...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2007.08.005
更新日期:2007-09-01 00:00:00
abstract::Two-component systems are characterized by phosphotransfer reactions involving histidine and aspartate residues in highly conserved signalling domains. Although the basic principles of signal transduction by these systems have been elucidated, several important aspects, such as their integration into more complex cell...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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更新日期:1999-03-01 00:00:00
abstract::Antifungal drug discovery is starting to benefit from the enormous advances in the genomics field, which have occurred in the past decade. As traditional drug screening on existing targets is not delivering the long-awaited potent antifungals, efforts to use novel genetics and genomics-based strategies to aid in the d...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2003.08.008
更新日期:2003-10-01 00:00:00
abstract::The identification and quantification of the proteins that a whole organism expresses under certain conditions is a main focus of high-throughput proteomics. Advanced proteomics approaches generate new biologically relevant data and potent hypotheses. A practical report of what proteome studies can and cannot accompli...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2006.03.005
更新日期:2006-05-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2017.05.015
更新日期:2017-12-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.01.007
更新日期:2018-04-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/S0966-842X(97)01107-4
更新日期:1997-09-01 00:00:00
abstract::The use of β-lactam antibiotics to treat infections caused by Staphylococcus aureus has been severely compromised by the acquisition by horizontal gene transfer of a gene that encodes the β-lactam-insensitive penicillin-binding protein PBP2a. This allows methicillin-resistant S. aureus (MRSA) to proliferate in the pre...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.06.005
更新日期:2019-01-01 00:00:00
abstract::The major regulator of sporulation initiation in Bacillus subtilis is the phosphorelay, a multicomponent signal transduction system. A myriad of signals, both positive and negative, from the environment, cell cycle and metabolism is received and interpreted by the phosphorelay and integrated through the opposing activ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(98)01350-x
更新日期:1998-09-01 00:00:00
abstract::The recent observation of a surge in human monkeypox in the Democratic Republic of the Congo (DRC) prompts the question of whether cessation of smallpox vaccination is driving the phenomenon, and if so, why is re-emergence not universal throughout the historic geographic range of the virus? Research addressing the vir...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2011.12.001
更新日期:2012-02-01 00:00:00
abstract::A new genetic locus mediating avirulence in the potato late blight pathogen Phytophthora infestans has been discovered. The Avr3b-Avr10-Avr11 locus is recognized by three different potato resistance genes, and is different from other Avr loci that have been identified thus far. This locus encodes a large protein with ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2006.09.004
更新日期:2006-11-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2016.06.010
更新日期:2016-11-01 00:00:00
abstract::The mechanisms that spatially regulate cytokinesis are more diverse than initially thought. In two recent publications a positive regulator of FtsZ positioning has been identified in Streptococcus pneumoniae. MapZ (LocZ) connects the division machinery with cell wall elongation, providing a simple mechanism to ensure ...
journal_title:Trends in microbiology
pub_type: 评论,杂志文章
doi:10.1016/j.tim.2015.02.001
更新日期:2015-03-01 00:00:00
abstract::Detection of pathogen-derived nucleic acids by pattern recognition receptors (PRRs) is essential for the host to mount an appropriate immune response, which for viruses involves the induction of type I interferons (IFNs). By contrast, inappropriate activation of PRRs by self nucleic acids can lead to autoimmunity. Rec...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2013.04.004
更新日期:2013-08-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2007.04.005
更新日期:2007-06-01 00:00:00
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journal_title:Trends in microbiology
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doi:10.1016/S0966-842X(97)01082-2
更新日期:1997-08-01 00:00:00
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journal_title:Trends in microbiology
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doi:10.1016/j.tim.2006.08.008
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2017.11.012
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abstract::Improved fluorescence techniques for visualizing proteins in whole bacterial cells have resulted in recent breakthroughs in our understanding of chromosome segregation and cytokinesis in prokaryotes. The dynamics and localization of some of these proteins reveal surprisingly cytoskeletal-like behavior. ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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更新日期:1998-06-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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更新日期:2001-10-01 00:00:00
abstract::New, post-genomic analyses are increasing the rate at which information about highly complex processes such as bacterial growth and development can be acquired. The recent use of DNA-microarray and proteomic analysis to study the differentiating bacterium Caulobacter crescentus has provided the first global view of th...
journal_title:Trends in microbiology
pub_type: 新闻
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更新日期:2001-09-01 00:00:00
abstract::Cyclopentenone prostanoids inhibit virus replication by turning on an intracellular defence response that involves the induction of cytoprotective heat-shock proteins, the modification of viral glycoprotein maturation and the control of NF-kappa B activation. These molecules represent an interesting model for the deve...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/S0966-842X(97)01066-4
更新日期:1997-07-01 00:00:00
abstract::Key skills such as communication and critical thinking are essential for today's microbiology graduate. There are many opportunities within the undergraduate curriculum to help students to use, develop and appreciate their own unique set of skills. This article describes personal experiences of research-led teaching a...
journal_title:Trends in microbiology
pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
abstract::The existence of peptidoglycan (PG) in chlamydiae has long been debated. Genome sequencing of members of the Chlamydiaceae family and Protochlamydia amoebophila has uncovered a nearly complete pathway for PG synthesis in these organisms. The recent use of microarray and proteomic analysis methods has revealed that PG ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2005.12.004
更新日期:2006-02-01 00:00:00
abstract::The human virome is the viral component of the microbiome. Its composition, and interindividual and temporal variability are not precisely known. Its impact on human health has received less attention than that of the bacterial microbiome, but is likely to be equally important, both in homeostasis and disease. Here we...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2013.07.001
更新日期:2013-10-01 00:00:00