Abstract：
:Viruses of the Mononegavirales have helical nucleocapsids containing a single-stranded negative-sense RNA genome complexed with the nucleoprotein and several other virus-encoded proteins. This RNA-protein complex acts as the template for replication and transcription during infection. Recent structural data has advanced our understanding of how these functions are achieved in filoviruses, which include dangerous pathogens such as Ebola virus. Polyploid filoviruses package multiple genome copies within strikingly long filamentous viral envelopes, which must be flexible to avoid breakage of the 19kb non-segmented genomic RNA. We review how the structure of filoviruses and paramyxoviruses permits this morphological flexibility in comparison to rhabdoviruses that have short, bullet-shaped virions with relatively rigid envelopes.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Booth TF,Rabb MJ,Beniac DRdoi
10.1016/j.tim.2013.08.001subject
Has Abstractpub_date
2013-11-01 00:00:00pages
583-93issue
11eissn
0966-842Xissn
1878-4380pii
S0966-842X(13)00153-4journal_volume
21pub_type
杂志文章,评审abstract：:Passive immunization studies, including a recent one by Pegu et al., have repeatedly shown that HIV-specific broadly neutralizing antibodies (bnAbs) protect rhesus macaques from HIV acquisition. In vitro neutralization potency and in vivo protection correlate very strongly, supporting the quest for an HIV vaccine that...
journal_title：Trends in microbiology
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/j.tim.2009.06.003
更新日期：2009-09-01 00:00:00
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/j.tim.2008.06.001
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
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