Acquisition and storage of inorganic iron and hemin by the yersiniae.

abstract：:The dramatic clinical manifestations of toxigenic infections such as cholera and diphtheria occur without substantial bacterial invasion. Disease is mediated by the secretion of potent toxins that use ADP-ribosylation as the catalytic mechanism underlying their action. ADP-ribosylating toxins comprise a large family, ...

journal_title：Trends in microbiology

authors： Lesnick ML,Guiney DG

更新日期：2001-01-01 00:00:00

abstract：:The evolution of virulence in Salmonella is driven by horizontal gene transfer. This has given rise to highly flexible pathogens that are able to colonize new niches and extend their host range. Tracing the record of horizontal gene transfer can provide clues to the virulence factors that contribute to the formation o...

journal_title：Trends in microbiology

authors： Bäumler AJ

更新日期：1997-08-01 00:00:00

abstract：:After the discovery that Zika virus (ZIKV) could cause microcephaly and other birth defects, we have scrambled to understand how. Now, spreading along with the virus is misinformation that a ZIKV mutation is responsible for microcephaly. Putting too much onus on a single mutation could enhance a crisis in India. ...

journal_title：Trends in microbiology

authors： Grubaugh ND,Ishtiaq F,Setoh YX,Ko AI

更新日期：2019-05-01 00:00:00

abstract：:DNA damage that blocks the transcription of genes is prioritized for repair by transcription-coupled DNA repair pathways. RNA polymerases stalled at DNA lesions obstruct repair enzymes, but this situation is turned to the advantage of the cell by transcription-repair coupling factors that remove the stalled RNA polyme...

journal_title：Trends in microbiology

authors： Savery NJ

更新日期：2007-07-01 00:00:00

abstract：:Microbiology has unraveled rich evidence of ongoing reticulate evolutionary processes and complex interactions both within and between cells. These phenomena feature real biological networks, which can logically be analyzed using network-based tools. It is thus not surprising that network sciences, a field independent...

journal_title：Trends in microbiology

authors： Papale F,Saget J,Bapteste É

更新日期：2020-04-01 00:00:00

abstract：:The recent availability of extensive metagenomic sequences from various environmental microbial communities has extended the postgenomic era to the field of environmental microbiology. Although still restricted to a small number of studies, metaproteomic investigations have revealed interesting aspects of functional g...

journal_title：Trends in microbiology

authors： Wilmes P,Bond PL

更新日期：2006-02-01 00:00:00

abstract：:In Gram-negative bacteria, type II secretion (T2S) is one of five protein secretion systems that permit the export of proteins from within the bacterial cell to the extracellular milieu and/or into target host cells. An analysis of numerous sequenced genomes now reveals that T2S genes are common, but by no means unive...

journal_title：Trends in microbiology

authors： Cianciotto NP

更新日期：2005-12-01 00:00:00

abstract：:Hepatitis C virus populations in infected individuals consist of quasispecies with diverse mutations. These quasispecies have different biological properties, and the analysis of these variants has led to new interpretations of viral persistence, carcinogenesis and resistance to interferon therapy. ...

journal_title：Trends in microbiology

authors： Enomoto N,Sato C

更新日期：1995-11-01 00:00:00

abstract：:The tricorn protease is an archaeal protease that forms massive proteasome-like capsids with a hollow chamber. beta-Propeller and PDZ domains are thought to play a role in substrate selection. By analysis of predicted proteins from novel bacterial genome sequences, we have identified four new bacterial tricorn-like pr...

journal_title：Trends in microbiology

authors： Pallen MJ,Lam AC,Loman N

更新日期：2001-11-01 00:00:00

abstract：:The mammalian immune system includes a sophisticated array of antimicrobial mechanisms. However, successful pathogens have developed subversive strategies to detect, modulate, and/or evade immune control and clearance. Independent disciplines study host immunology and bacterial pathogenesis, but interkingdom signaling...

journal_title：Trends in microbiology

authors： Gestal MC,Whitesides LT,Harvill ET

更新日期：2019-02-01 00:00:00

abstract：:Proteins embedded in membranes are important for helping the cell adapt to changes in the extracellular milieu and often play key roles in the life cycles of pathogenic microbes. Bioinformatic predictions can provide an estimate of membrane proteins, but experimental approaches of detection are required for a deeper u...

journal_title：Trends in microbiology

authors： Bernsel A,Daley DO

更新日期：2009-10-01 00:00:00

abstract：:Recently, a new group of multicellular microorganisms was discovered, called 'cable bacteria', which are capable of generating and mediating electrical currents across centimetre-scale distances. By transporting electrons from cell to cell, cable bacteria can harvest electron donors and electron acceptors that are wid...

journal_title：Trends in microbiology

authors： Meysman FJR

更新日期：2018-05-01 00:00:00

abstract：:Gram-negative bacteria produce repeats-in-toxin adhesion proteins (RTX adhesins) to facilitate microbial adhesion. These large, multidomain proteins share a common architecture comprised of four regions. First to emerge from the bacterium, C terminal end leading, is the RTX export sequence that directs the protein thr...

journal_title：Trends in microbiology

authors： Guo S,Vance TDR,Stevens CA,Voets I,Davies PL

更新日期：2019-05-01 00:00:00

abstract：:A major goal in microbiology is to understand the processes by which bacteria successfully colonize host tissue. Although a wealth of studies focusing on pathogenic microorganisms has revealed much about the rare interactions that result in disease, far less is known about the regulation of the ubiquitous, long-term, ...

journal_title：Trends in microbiology

authors： Ruby EG,McFall-Ngai MJ

更新日期：1999-10-01 00:00:00

abstract：:The lipid phosphatidylethanolamine (PE) is the first chemoattractant to be described for a surface-motile bacterium. In Myxococcus xanthus, the specific activity of PE is determined by its fatty acid components. Two active species have been identified: dilauroyl PE and dioleoyl PE. Excitation to dilauroyl PE requires ...

journal_title：Trends in microbiology

authors： Kearns DB,Shimkets LJ

更新日期：2001-03-01 00:00:00

abstract：:Meningococcal infection remains a worldwide health problem, and understanding the mechanisms by which Neisseria meningitidis evades host innate and acquired immunity is crucial. The complement system is vital for protecting individuals against N. meningitidis. However, this pathogen has evolved several mechanisms to a...

journal_title：Trends in microbiology

authors： Schneider MC,Exley RM,Ram S,Sim RB,Tang CM

更新日期：2007-05-01 00:00:00

abstract：:H3N2-subtype influenza A viruses are major causes of seasonal influenza epidemics. Emerging H3N2 variants require the annual adjustment of the vaccine strain. Recently, studies addressing the reduced effectiveness of current H3N2 vaccines have identified production-related substitutions in the viral hemagglutinin anti...

journal_title：Trends in microbiology

authors： Mostafa A,Pleschka S

更新日期：2018-02-01 00:00:00

abstract：:Rhizobia are soil bacteria that can become endosymbionts, reducing atmospheric nitrogen within nodules formed on the roots of legume plants. During tissue and cell invasion, bacterial cell-surface components adapt the bacterium to survive as an endophyte without eliciting host-defence responses. The structures of many...

journal_title：Trends in microbiology

authors： Kannenberg EL,Brewin NJ

更新日期：1994-08-01 00:00:00

abstract：:Bacteriophages are viruses of bacteria that are used for controlling bacterial food-borne pathogens and have been proposed for more extensive usage in infection control. Protists are now recognised to harbour viruses and virus-like particles. We propose that investigation of their prevalence in parasites be intensifie...

journal_title：Trends in microbiology

authors： Hyman P,Atterbury R,Barrow P

更新日期：2013-05-01 00:00:00

abstract：:Viruses that have coevolved with their host establish chronic infections that are well tolerated by the host. Other viruses, that are partly adapted to their host, may induce chronic infections where persistent replication and viral antigen expression occur. The former induce highly functional and resilient CD8T cell ...

journal_title：Trends in microbiology

authors： Cicin-Sain L,Arens R

更新日期：2018-06-01 00:00:00

abstract：:Several attempts have been made to identify the minimal set of genes that is required for life using computational approaches or studies of deletion mutants. These experiments resemble those already performed by nature; a few hundred million years ago an ancestor of Escherichia coli was domesticated by aphids, which r...

journal_title：Trends in microbiology

authors： Klasson L,Andersson SG

更新日期：2004-01-01 00:00:00

abstract：:Pathogens survive and propagate within host cells through a wide array of complex interactions. Tracking the molecular and cellular events by multidimensional fluorescence microscopy has been a widespread tool for research on intracellular pathogens. Through major advancements in 3D electron microscopy, intracellular ...

journal_title：Trends in microbiology

authors： Weiner A,Enninga J

更新日期：2019-05-01 00:00:00

abstract：:Horizontal gene transfer can provide bacteria with new functions that confer an important competitive advantage, and is therefore likely to affect the dynamics of bacterial ecosystems. Two studies by Wolfe et al. and Bonham et al. prepare the way to study this hypothesis in a model ecosystem with reproducible properti...

journal_title：Trends in microbiology

authors： van de Guchte M

更新日期：2017-09-01 00:00:00

abstract：:The susceptibility of Caenorhabditis elegans to different virulent phenotypes of Pseudomonas aeruginosa makes the worms an excellent model for studying host-pathogen interactions. Including the recently described liquid killing, five different killing assays are now available offering superb possibilities for performi...

journal_title：Trends in microbiology

authors： Utari PD,Quax WJ

更新日期：2013-07-01 00:00:00

abstract：:If we took all of the single copy genes in all sequenced genomes, made phylogenetic trees from them individually, and then made the supertree of those trees, what would we get? Recently, David Pisani and colleagues did that experiment and their results are likely to spark much discussion. Their prokaryote tree looks v...

journal_title：Trends in microbiology

authors： Esser C,Martin W

更新日期：2007-10-01 00:00:00

abstract：:Filamentous phages are small, highly evolved parasites that can reproduce and disseminate without killing their host. During assembly, virion proteins are transferred from the host membrane to the single-stranded DNA phase genome and simultaneously secreted from the cell. Filamentous phage assembly shares certain feat...

journal_title：Trends in microbiology

authors： Russel M

更新日期：1995-06-01 00:00:00

abstract：:Initial hepatitis B virus (HBV) attachment occurs via heparan sulfate proteoglycans (HSPGs), which then trigger receptor-mediated internalization. Although HSPGs express in many tissues, HBV is destined for hepatotropic infection. A recent paper by Seitz et al. proposed that the slow viral maturation process plays a c...

journal_title：Trends in microbiology

authors： Watashi K

更新日期：2016-08-01 00:00:00

abstract：:The discovery of 'molecular syringes' in several important gastrointestinal pathogens including Escherichia coli, Salmonella, Shigella and Yersinia, together with a better understanding of M cells and the mucosal immune system, has advanced our appreciation of multistage microorganism-host cell interactions. Recent st...

journal_title：Trends in microbiology

authors： Autenrieth IB,Schmidt MA

更新日期：2000-10-01 00:00:00

abstract：:Over the past two decades infections due to antibiotic-resistant bacteria have escalated world-wide, affecting patient morbidity, mortality, and health care costs. Among these bacteria, Enterococcus faecium and Enterococcus faecalis represent opportunistic nosocomial pathogens that cause difficult-to-treat infections ...

journal_title：Trends in microbiology

authors： van Harten RM,Willems RJL,Martin NI,Hendrickx APA

更新日期：2017-06-01 00:00:00

abstract：:The human virome is the viral component of the microbiome. Its composition, and interindividual and temporal variability are not precisely known. Its impact on human health has received less attention than that of the bacterial microbiome, but is likely to be equally important, both in homeostasis and disease. Here we...

journal_title：Trends in microbiology

authors： Lecuit M,Eloit M

更新日期：2013-10-01 00:00:00