Abstract:
:Growing concerns about global climate change and energy dependence have led to an increased effort to reduce carbon emissions. A considerable reduction could be achieved by using biofuels from lignocellulosic biomass instead of fossil fuels. One major bottleneck of biofuel production from lignocellulose is the availability of efficient and inexpensive biocatalysts (i.e. alcohol dehydrogenases, cellulases and esterases) that are active and stable at high temperatures and low pH values. Although heterologous gene expression is used effectively to obtain recombinant proteins derived from mesophiles, the production of thermoacidophilic proteins is often unsuccessful. Some of the reasons for this failure and potential solutions for an increased production of novel extremophilic biocatalysts are discussed here.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Hess Mdoi
10.1016/j.tim.2008.06.001subject
Has Abstractpub_date
2008-09-01 00:00:00pages
414-9issue
9eissn
0966-842Xissn
1878-4380pii
S0966-842X(08)00161-3journal_volume
16pub_type
杂志文章abstract::Recently, a new group of multicellular microorganisms was discovered, called 'cable bacteria', which are capable of generating and mediating electrical currents across centimetre-scale distances. By transporting electrons from cell to cell, cable bacteria can harvest electron donors and electron acceptors that are wid...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2017.10.011
更新日期:2018-05-01 00:00:00
abstract::The endogenous circadian clock of the cyanobacterium Synechococcus elongatus controls many cellular processes and confers an adaptive advantage on this organism in a competitive environment. To be advantageous, this internal biological oscillator must be reset daily to remain in synchrony with its environment and to t...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2007.08.005
更新日期:2007-09-01 00:00:00
abstract::The term 'type III secretion' has seen widespread use. However, problems persist in nomenclature. We propose that the standard abbreviation for this kind of secretion should be 'T3S' and that 'type III secretion system' should be abbreviated to 'T3SS'. There is also a need for a new terminology to distinguish flagella...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2006.02.009
更新日期:2006-04-01 00:00:00
abstract::After the discovery that Zika virus (ZIKV) could cause microcephaly and other birth defects, we have scrambled to understand how. Now, spreading along with the virus is misinformation that a ZIKV mutation is responsible for microcephaly. Putting too much onus on a single mutation could enhance a crisis in India. ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2019.02.004
更新日期:2019-05-01 00:00:00
abstract::Activation of innate immune signaling pathways through cytosolic RIG-I-like receptors (RLR) is a crucial response that is antagonized by many viruses. A variety of RNA-related pathogen-associated molecular patterns (PAMPS) have been identified and their role in RLR activation has been examined. Recent studies suggest ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2011.12.005
更新日期:2012-03-01 00:00:00
abstract::Because the structure of the tobacco mosaic virus capsid protein is known, mutations that alter the phenotype of the virus-plant interaction can be correlated with structural changes in this protein. These mutations affect the disease symptoms caused by the virus and recognition of the virus by a plant resistance gene...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/0966-842x(93)90052-s
更新日期:1993-10-01 00:00:00
abstract::Several times in this century, new and sometimes devastating diseases of cereal crops, caused by fungi in the genus Cochliobolus, have suddenly appeared. In many fungal diseases of plants the factors required for pathogenicity are unknown; in contrast, the key elements in each of several Cochliobolus diseases are know...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/0966-842x(93)90019-n
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2007.02.003
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2016.03.008
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journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2020.02.009
更新日期:2020-08-01 00:00:00
abstract::Genome analyses of double strand DNA tailed bacteriophages argue that they evolve by recombinational reassortment of genes and by the acquisition of novel genes as simple genetic elements termed morons. These processes suggest a model for early virus evolution, wherein viruses can be regarded less as having derived fr...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(00)01863-1
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abstract::Neuronotropic viruses induce apoptosis in neurons, and Bcl-2-related anti-apoptotic proteins and caspase inhibitors decrease mortality from acute viral encephalitis. Infected neurons develop cytoplasmic blebbing characteristic of apoptosis, but a paucity of apoptotic nuclear changes potentially indicates unique aspect...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(99)01470-5
更新日期:1999-04-01 00:00:00
abstract::Evolution, climate change, and vaccination: in these cases and more, scientists, policymakers, and educators are confronted by organized campaigns to spread doubt, denial, and rejection of the scientific community's consensus on central scientific principles. To overcome these threats, scientists not only need to spre...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2012.10.002
更新日期:2012-12-01 00:00:00
abstract::The interferon-inducible, transmembrane protein BST-2 (CD317, tetherin) directly holds fully formed enveloped virus particles to the cells that produce them, inhibiting their spread. BST-2 inhibits members of the retrovirus, filovirus, arenavirus and herpesvirus families. These viruses encode a variety of proteins to ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2010.06.010
更新日期:2010-09-01 00:00:00
abstract::Rolling circle DNA replication is inherently continuous and unregulated. This 'go-for-broke' strategy works well for lytic phages but is suicidal for plasmids that must coexist with their host. Plasmids have consequently evolved elaborate copy number control systems that operate at the transcriptional, translational a...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/S0966-842X(97)01143-8
更新日期:1997-11-01 00:00:00
abstract::The use of quality control mechanisms to stall developmental pathways or completely remove defective cells from a population is a widespread strategy to ensure the integrity of morphogenetic programs. Endospore formation (sporulation) is a well conserved microbial developmental strategy in the Firmicutes phylum wherei...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2017.03.005
更新日期:2017-08-01 00:00:00
abstract::Antifungal drug discovery is starting to benefit from the enormous advances in the genomics field, which have occurred in the past decade. As traditional drug screening on existing targets is not delivering the long-awaited potent antifungals, efforts to use novel genetics and genomics-based strategies to aid in the d...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2003.08.008
更新日期:2003-10-01 00:00:00
abstract::The discovery of 'molecular syringes' in several important gastrointestinal pathogens including Escherichia coli, Salmonella, Shigella and Yersinia, together with a better understanding of M cells and the mucosal immune system, has advanced our appreciation of multistage microorganism-host cell interactions. Recent st...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(00)01828-x
更新日期:2000-10-01 00:00:00
abstract::Viruses have evolved complex and dynamic interactions with their host cell. In recent years we have gained insight into the expanding roles for host lipids in the virus life cycle. In particular, viruses target lipid signaling, synthesis, and metabolism to remodel their host cells into an optimal environment for their...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2011.03.007
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journal_title:Trends in microbiology
pub_type: 杂志文章
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abstract::For many years, there has been controversy over the role of antibodies in immunity to Candida, but recently specific antibodies to mannoproteins and hsp90 have been shown to be protective against murine candidiasis. Combined with technical advances in antibody engineering, this raises the possibility of harnessing suc...
journal_title:Trends in microbiology
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abstract::Genomics is fast becoming a routine tool in medical diagnostics and cutting-edge biotechnologies. Yet, its use for environmental biomonitoring is still considered a futuristic ideal. Until now, environmental genomics was mainly used as a replacement of the burdensome morphological identification, to screen known morph...
journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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abstract::Recent emerging evidence has revealed that regulatory noncoding RNAs (microRNAs, circular RNAs) modulate host-microbe interactions and they have been proposed as potential biomarkers of the host's response to microbiome-linked pathologies such as cancers, obesity, and neurodegenerative diseases. Interactions between m...
journal_title:Trends in microbiology
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abstract::Bacteriophages are viruses of bacteria that are used for controlling bacterial food-borne pathogens and have been proposed for more extensive usage in infection control. Protists are now recognised to harbour viruses and virus-like particles. We propose that investigation of their prevalence in parasites be intensifie...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2013.02.006
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abstract::Multidrug resistance in tumor cells is often caused by the increased efflux of a wide variety of drugs, mediated by P glycoprotein, a member of the superfamily of ATP-binding cassette (ABC) transporters. The genes encoding members of this superfamily have also been isolated from drug-resistant microorganisms, and the ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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abstract::The forms of African trypanosomes that live in tsetse fly vectors are coated with lipid-anchored proteins and glycoproteins known collectively as procyclins. Procyclins are expressed during development in the fly in a multiplicity of isoforms yet their functions remain unknown. Recent studies involving a multidiscipli...
journal_title:Trends in microbiology
pub_type: 新闻
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abstract::Mycoplasmas are minute wall-less bacterial parasites that exhibit strict host and tissue specificities. They enter, multiply and survive within the host for extended periods by circumventing host defenses. Their intimate interaction with eukaryotic cells, and in some cases the subsequent invasion into or fusion with t...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(98)01358-4
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abstract::The mechanisms that spatially regulate cytokinesis are more diverse than initially thought. In two recent publications a positive regulator of FtsZ positioning has been identified in Streptococcus pneumoniae. MapZ (LocZ) connects the division machinery with cell wall elongation, providing a simple mechanism to ensure ...
journal_title:Trends in microbiology
pub_type: 评论,杂志文章
doi:10.1016/j.tim.2015.02.001
更新日期:2015-03-01 00:00:00
abstract::Badgers represent a wildlife reservoir for bovine tuberculosis in Britain, which persists in the south west despite almost 20 years of badger control. The influence of landscape structure on patterns of badger urinatory behaviour may be one reason for the localized persistence of the disease in cattle within the regio...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/0966-842x(94)90124-4
更新日期:1994-02-01 00:00:00