Abstract:
:Genomics is fast becoming a routine tool in medical diagnostics and cutting-edge biotechnologies. Yet, its use for environmental biomonitoring is still considered a futuristic ideal. Until now, environmental genomics was mainly used as a replacement of the burdensome morphological identification, to screen known morphologically distinguishable bioindicator taxa. While prokaryotic and eukaryotic microbial diversity is of key importance in ecosystem functioning, its implementation in biomonitoring programs is still largely unappreciated, mainly because of difficulties in identifying microbes and limited knowledge of their ecological functions. Here, we argue that the combination of massive environmental genomics microbial data with machine learning algorithms can be extremely powerful for biomonitoring programs and pave the way to fill important gaps in our understanding of microbial ecology.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Cordier T,Lanzén A,Apothéloz-Perret-Gentil L,Stoeck T,Pawlowski Jdoi
10.1016/j.tim.2018.10.012subject
Has Abstractpub_date
2019-05-01 00:00:00pages
387-397issue
5eissn
0966-842Xissn
1878-4380pii
S0966-842X(18)30238-5journal_volume
27pub_type
杂志文章,评审abstract::Increasing evidence indicates that Staphylococcus aureus might be a facultative intracellular pathogen. In particular, certain subpopulations, called small colony variants (SCVs), seem to be well adapted to the intracellular milieu. When compared to 'normal' staphylococcal strains, SCVs show increased uptake by host c...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2008.11.004
更新日期:2009-02-01 00:00:00
abstract::The pleiotropic post-transcriptional regulator Hfq is an RNA chaperone that facilitates pairing interactions between small regulatory RNAs (sRNAs) and their mRNA targets in several bacteria. However, this classical pattern, derived from the Escherichia coli model, is not applicable to the whole bacterial kingdom. In t...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2009.06.003
更新日期:2009-09-01 00:00:00
abstract::The intestine harbors an ecosystem composed of the intestinal mucosa and the commensal microbiota. The microbiota fosters development, aids digestion and protects host cells from pathogens - a function referred to as colonization resistance. Little is known about the molecular basis of colonization resistance and how ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2007.12.008
更新日期:2008-03-01 00:00:00
abstract::The tricorn protease is an archaeal protease that forms massive proteasome-like capsids with a hollow chamber. beta-Propeller and PDZ domains are thought to play a role in substrate selection. By analysis of predicted proteins from novel bacterial genome sequences, we have identified four new bacterial tricorn-like pr...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/s0966-842x(01)02199-0
更新日期:2001-11-01 00:00:00
abstract::Pathogenic Yersinia express a complex array of iron-regulated functions and possess mechanisms for inorganic iron and hemin acquisition. These include a unique temperature-regulated hemin storage system, high-affinity transport processes for hemin and inorganic iron, and an iron-responsive regulatory system controllin...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/0966-842x(93)90129-f
更新日期:1993-07-01 00:00:00
abstract::Recent American successes against poliomyelitis and measles have been attributed to repeated 'pulse' vaccination campaigns. Whilst logistic and economic constraints will be crucial, a deeper epidemiological understanding of the mechanism, strengths and weaknesses of pulse vaccination will optimize the chances of succe...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/S0966-842X(97)81769-6
更新日期:1997-01-01 00:00:00
abstract::Bacterial motility relies chiefly on the rotation of a molecular propeller, the flagellar filament, which is constructed from the protein flagellin. Here, flagellin sequence conservation and diversity is examined in the light of the recently determined flagellar filament structure. As expected, the surface-exposed dom...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2006.02.008
更新日期:2006-04-01 00:00:00
abstract::Horizontal gene transfer can provide bacteria with new functions that confer an important competitive advantage, and is therefore likely to affect the dynamics of bacterial ecosystems. Two studies by Wolfe et al. and Bonham et al. prepare the way to study this hypothesis in a model ecosystem with reproducible properti...
journal_title:Trends in microbiology
pub_type: 评论,杂志文章
doi:10.1016/j.tim.2017.07.002
更新日期:2017-09-01 00:00:00
abstract::Several times in this century, new and sometimes devastating diseases of cereal crops, caused by fungi in the genus Cochliobolus, have suddenly appeared. In many fungal diseases of plants the factors required for pathogenicity are unknown; in contrast, the key elements in each of several Cochliobolus diseases are know...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/0966-842x(93)90019-n
更新日期:1993-04-01 00:00:00
abstract::DNA vaccines can induce potent humoral and cellular immune responses without any additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within DNA vaccines are immune stimulatory and exert an essential endogenous adjuvant activity. These CpG motifs can be added deliberately to DNA or conventi...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/S0966-842X(97)01145-1
更新日期:1998-01-01 00:00:00
abstract::Entomopathogenic fungi are attracting attention as potential biological control agents of insect pests. The mechanisms of pathogenesis have parallels with those of some plant-pathogenic fungi, particularly in the areas of formation of an infection structure, entry into the host and toxin-mediated host death. Understan...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/0966-842x(96)10022-6
更新日期:1996-05-01 00:00:00
abstract::Filamentous phages are small, highly evolved parasites that can reproduce and disseminate without killing their host. During assembly, virion proteins are transferred from the host membrane to the single-stranded DNA phase genome and simultaneously secreted from the cell. Filamentous phage assembly shares certain feat...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(00)88929-5
更新日期:1995-06-01 00:00:00
abstract::Pathogens survive and propagate within host cells through a wide array of complex interactions. Tracking the molecular and cellular events by multidimensional fluorescence microscopy has been a widespread tool for research on intracellular pathogens. Through major advancements in 3D electron microscopy, intracellular ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.11.011
更新日期:2019-05-01 00:00:00
abstract::The bacterial flagellum is a complex self-assembling nanomachine that contains its own type III protein export apparatus. Upon completion of early flagellar structure, this apparatus switches substrate specificity to export late structural subunits, thereby coupling sequential flagellar gene expression with flagellar ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2006.10.006
更新日期:2006-12-01 00:00:00
abstract::The mammalian immune system includes a sophisticated array of antimicrobial mechanisms. However, successful pathogens have developed subversive strategies to detect, modulate, and/or evade immune control and clearance. Independent disciplines study host immunology and bacterial pathogenesis, but interkingdom signaling...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.09.010
更新日期:2019-02-01 00:00:00
abstract::A recent study has provided important clues towards the identity of the host genes that conspire to promote post-integration latency of human immunodeficiency virus (HIV). Various genes controlling transcription, histone deacetylation and proteasome-mediated protein degradation have emerged as potential players. If th...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2005.02.006
更新日期:2005-04-01 00:00:00
abstract::The recent observation of a surge in human monkeypox in the Democratic Republic of the Congo (DRC) prompts the question of whether cessation of smallpox vaccination is driving the phenomenon, and if so, why is re-emergence not universal throughout the historic geographic range of the virus? Research addressing the vir...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2011.12.001
更新日期:2012-02-01 00:00:00
abstract::Progress in understanding the evolution of infectious diseases has inspired proposals to manage the evolution of pathogen (including parasite) virulence. A common view is that social interventions that lower pathogen transmission will indirectly select lower virulence because of a trade-off between transmission and vi...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/s0966-842x(02)00003-3
更新日期:2003-01-01 00:00:00
abstract::Subunit vaccines based on recombinant proteins can suffer from poor immunogenicity owing to incorrect folding of the target protein or poor presentation to the immune system. Virus-like particles (VLPs) represent a specific class of subunit vaccine that mimic the structure of authentic virus particles. They are recogn...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(03)00208-7
更新日期:2003-09-01 00:00:00
abstract::Pathogenic viral infections have exerted selection pressure on their hosts to evolve cellular antiviral inhibitors referred to as restriction factors. Examples of such molecules are APOBEC3G, APOBEC3F and TRIM5alpha. APOBEC3G and APOBEC3F are cytidine deaminases that are able to strongly inhibit retroviral replication...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2008.08.013
更新日期:2008-12-01 00:00:00
abstract::Microbial pathogens possess a diversity of weapons that disrupt host homeostasis and immune defenses, thus resulting in the establishment of infection. The best-characterized system mediating bacterial protein delivery into target eukaryotic cells is the type III secretion system (T3SS) expressed by Gram-negative bact...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.01.010
更新日期:2018-04-01 00:00:00
abstract::The use of quality control mechanisms to stall developmental pathways or completely remove defective cells from a population is a widespread strategy to ensure the integrity of morphogenetic programs. Endospore formation (sporulation) is a well conserved microbial developmental strategy in the Firmicutes phylum wherei...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2017.03.005
更新日期:2017-08-01 00:00:00
abstract::Resistance to tetracycline is generally due either to energy-dependent efflux of tetracycline or to protection of the bacterial ribosomes from the action of tetracycline. The genes that encode this resistance are normally acquired via transferable plasmids and/or transposons. Tet determinants have been found in a wide...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/0966-842x(94)90610-6
更新日期:1994-10-01 00:00:00
abstract::Multidrug resistance in tumor cells is often caused by the increased efflux of a wide variety of drugs, mediated by P glycoprotein, a member of the superfamily of ATP-binding cassette (ABC) transporters. The genes encoding members of this superfamily have also been isolated from drug-resistant microorganisms, and the ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/0966-842x(94)90620-3
更新日期:1994-10-01 00:00:00
abstract::Symbioses between eukaryotes and unicellular organisms are quite common, with examples copiously disseminated throughout the earth's biota. Arthropods, in particular, owe much of their ecological success to their microbial flora, which often provide supplements either lacking in the limited host diet or which the host...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2004.05.001
更新日期:2004-07-01 00:00:00
abstract::Intracellular pathogens customize the composition and function of the vacuoles they occupy, and can arrest or distort vacuolar maturation. In doubly infected cells, vacuoles that contain two different parasites can be used to test for exclusionary mechanisms, for expression of vacuolar phenotypes that permit or restri...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/0966-842x(96)10027-5
更新日期:1996-04-01 00:00:00
abstract::The interferon-inducible, transmembrane protein BST-2 (CD317, tetherin) directly holds fully formed enveloped virus particles to the cells that produce them, inhibiting their spread. BST-2 inhibits members of the retrovirus, filovirus, arenavirus and herpesvirus families. These viruses encode a variety of proteins to ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2010.06.010
更新日期:2010-09-01 00:00:00
abstract::Interbacterial communication can be mediated by soluble secreted factors and direct cell-cell contact. Recently, Aoki et al. identified a new contact-dependent communication pathway by which strains of uropathogenic Escherichia coli can inhibit the growth of other microbes within a mixed population. Two novel gene pro...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2005.12.003
更新日期:2006-02-01 00:00:00
abstract::The assembly of microbial communities within the gastrointestinal tract during early life plays a critical role in immune, endocrine, metabolic, and other host developmental pathways. Environmental insults during this period, such as food insecurity and infections, can disrupt this optimal microbial succession, which ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.09.008
更新日期:2019-02-01 00:00:00
abstract::Fungal growth, development and pathogenicity require hyphal tip growth, which is supported by polar exocytosis at the expanding growth region. It is assumed that molecular motors transport growth supplies along the fibrous elements of the cytoskeleton, such as microtubules, to the hyphal apex. Recent advances in live-...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2006.11.007
更新日期:2007-01-01 00:00:00