Oxygen-dependent anti-Salmonella activity of macrophages.

Abstract:

:Numerous observations have established a crucial role for phagocytic cells in host resistance to Salmonella. Activated macrophages rely on a complex array of oxygen-dependent antimicrobial molecules to inhibit or kill intracellular Salmonella. An initial oxidative bactericidal phase, which is dependent on the respiratory burst phagocyte oxidase (phox) is succeeded by a prolonged nitrosative bacteriostatic phase, which is dependent on inducible nitric oxide synthase (iNOS). The sequential contribution of phox and iNOS to anti-Salmonella innate immunity has been demonstrated both in vitro and in vivo. The temporal progression from the predominant production of reactive oxygen species to the production of nitrogen oxides could optimize the initial reduction in microbial burden while minimizing the immunopathological consequences of the host inflammatory response.

journal_name

Trends Microbiol

journal_title

Trends in microbiology

authors

Vazquez-Torres A,Fang FC

doi

10.1016/s0966-842x(00)01897-7

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

29-33

issue

1

eissn

0966-842X

issn

1878-4380

pii

S0966-842X(00)01897-7

journal_volume

9

pub_type

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