Abstract：
:The fungus Candida albicans is a benign member of the mucosal microbiota, but can cause mucosal infections and life-threatening disseminated invasive infections in susceptible individuals. The ability to switch between yeast, pseudohyphal, and hyphal growth forms (polymorphism) is one of the most investigated virulence attributes of C. albicans. Recent studies suggest that hyphal development in C. albicans requires two temporally linked regulations for initiation and maintenance of the hyphal transcriptional program. Hyphal initiation requires a rapid but temporary disappearance of the Nrg1 transcriptional repressor of hyphal morphogenesis. Hyphal maintenance requires active sensing of the surrounding environment, leading to exclusion of Nrg1 binding to promoters of hypha-specific genes or reduced NRG1 expression. We discuss recent advances in understanding the complex transcriptional regulation of hyphal gene expression. These provide molecular mechanisms underpinning the phenotypic plasticity of C. albicans polymorphism.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Lu Y,Su C,Liu Hdoi
10.1016/j.tim.2014.09.001subject
Has Abstractpub_date
2014-12-01 00:00:00pages
707-14issue
12eissn
0966-842Xissn
1878-4380pii
S0966-842X(14)00180-2journal_volume
22pub_type
杂志文章,评审abstract：:For many years, there has been controversy over the role of antibodies in immunity to Candida, but recently specific antibodies to mannoproteins and hsp90 have been shown to be protective against murine candidiasis. Combined with technical advances in antibody engineering, this raises the possibility of harnessing suc...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/0966-842x(96)10056-1
更新日期：1996-09-01 00:00:00
abstract：:Recent emerging evidence has revealed that regulatory noncoding RNAs (microRNAs, circular RNAs) modulate host-microbe interactions and they have been proposed as potential biomarkers of the host's response to microbiome-linked pathologies such as cancers, obesity, and neurodegenerative diseases. Interactions between m...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2020.12.003
更新日期：2021-01-05 00:00:00
abstract：:The existence of a peptidoglycan cell wall in chlamydiae has been debated for several years. Several studies suggest that these organisms synthesize a cell wall, but some of the components and biosynthetic machinery seem to be missing and a bona fide cell wall has yet to be described. A recent study has revealed that ...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2007.02.003
更新日期：2007-04-01 00:00:00
abstract：:The interferon-inducible, transmembrane protein BST-2 (CD317, tetherin) directly holds fully formed enveloped virus particles to the cells that produce them, inhibiting their spread. BST-2 inhibits members of the retrovirus, filovirus, arenavirus and herpesvirus families. These viruses encode a variety of proteins to ...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2010.06.010
更新日期：2010-09-01 00:00:00
abstract：:Gram-negative bacteria produce repeats-in-toxin adhesion proteins (RTX adhesins) to facilitate microbial adhesion. These large, multidomain proteins share a common architecture comprised of four regions. First to emerge from the bacterium, C terminal end leading, is the RTX export sequence that directs the protein thr...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2018.12.003
更新日期：2019-05-01 00:00:00
abstract：:The recent observation of a surge in human monkeypox in the Democratic Republic of the Congo (DRC) prompts the question of whether cessation of smallpox vaccination is driving the phenomenon, and if so, why is re-emergence not universal throughout the historic geographic range of the virus? Research addressing the vir...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2011.12.001
更新日期：2012-02-01 00:00:00
abstract：:Bacterial motility relies chiefly on the rotation of a molecular propeller, the flagellar filament, which is constructed from the protein flagellin. Here, flagellin sequence conservation and diversity is examined in the light of the recently determined flagellar filament structure. As expected, the surface-exposed dom...
journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/j.tim.2006.02.008
更新日期：2006-04-01 00:00:00
abstract：:Selected bacterial pathogens, such as Helicobacter pylori and Mycobacterium tuberculosis, establish persistent infections in mammalian hosts despite activating inflammatory and antimicrobial responses. The strategies used to overcome host defense responses vary with the anatomical location of the infection but often r...
journal_title：Trends in microbiology
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doi：10.1016/s0966-842x(02)00038-0
更新日期：2003-02-01 00:00:00
abstract：:Many plant pathogens subvert host immunity by injecting compositionally diverse but functionally similar repertoires of cytoplasmic effector proteins. The bacterial pathogen Pseudomonas syringae is a model for exploring the functional structure of such repertoires. The pangenome of P. syringae encodes 57 families of e...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2012.01.003
更新日期：2012-04-01 00:00:00
abstract：:The health of tens of millions of people world-wide is at risk from drinking arsenic-contaminated well water. In most cases this arsenic occurs naturally within the sub-surface aquifers, rather than being derived from identifiable point sources of pollution. The mobilization of arsenic into the aqueous phase is the fi...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2004.12.002
更新日期：2005-02-01 00:00:00
abstract：:Neuronotropic viruses induce apoptosis in neurons, and Bcl-2-related anti-apoptotic proteins and caspase inhibitors decrease mortality from acute viral encephalitis. Infected neurons develop cytoplasmic blebbing characteristic of apoptosis, but a paucity of apoptotic nuclear changes potentially indicates unique aspect...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/s0966-842x(99)01470-5
更新日期：1999-04-01 00:00:00
abstract：:In nongrowing microbes, proteome turnover is reduced and identification of newly synthesized, low-abundance proteins is challenging. Babin and colleagues recently utilized bio-orthogonal noncanonical amino acid tagging (BONCAT) to identify actively synthesized proteins in nongrowing Pseudomonas aeruginosa, discovering...
journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/j.tim.2016.02.014
更新日期：2016-05-01 00:00:00
abstract：:The identification and quantification of the proteins that a whole organism expresses under certain conditions is a main focus of high-throughput proteomics. Advanced proteomics approaches generate new biologically relevant data and potent hypotheses. A practical report of what proteome studies can and cannot accompli...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2006.03.005
更新日期：2006-05-01 00:00:00
abstract：:Most cases of candidiasis have been attributed to Candida albicans, but Candida glabrata, Candida parapsilosis and Candida tropicalis, designated as non-C. albicans Candida (NCAC), have been identified as frequent human pathogens. Moreover, Candida biofilms are an escalating clinical problem associated with significan...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2016.09.004
更新日期：2017-01-01 00:00:00
abstract：:Key skills such as communication and critical thinking are essential for today's microbiology graduate. There are many opportunities within the undergraduate curriculum to help students to use, develop and appreciate their own unique set of skills. This article describes personal experiences of research-led teaching a...
journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/j.tim.2009.12.006
更新日期：2010-02-01 00:00:00
abstract：:The STING (Stimulator of Interferon Genes) protein connects microorganism cytosolic sensing with effector functions of the host cell by sensing directly cyclic dinucleotides (CDNs), originating from pathogens or from the host upon DNA recognition. Although STING activation favors effective immune responses against vir...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2017.05.008
更新日期：2017-11-01 00:00:00
abstract：:Recognizing the respiratory tract as a dynamic and complex ecosystem has enhanced our understanding of the pathophysiology of bovine respiratory disease (BRD). There is widespread evidence showing that disease-predisposing factors often disrupt the respiratory microbial ecosystem, provoking atypical colonization patte...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2019.04.005
更新日期：2019-09-01 00:00:00
abstract：:Rhizobia are soil bacteria that can become endosymbionts, reducing atmospheric nitrogen within nodules formed on the roots of legume plants. During tissue and cell invasion, bacterial cell-surface components adapt the bacterium to survive as an endophyte without eliciting host-defence responses. The structures of many...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/0966-842x(94)90004-3
更新日期：1994-08-01 00:00:00
abstract：:Microbiology has unraveled rich evidence of ongoing reticulate evolutionary processes and complex interactions both within and between cells. These phenomena feature real biological networks, which can logically be analyzed using network-based tools. It is thus not surprising that network sciences, a field independent...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2019.11.006
更新日期：2020-04-01 00:00:00
abstract：:Virulence of many bacterial pathogens is based, at least in part, on the action of phospholipases. The consequences may be immediate and direct, as in the action of Clostridium perfringens alpha toxin on red cells or platelets, or subtle, as with phosphatidylinositol-specific phospholipases of Listeria monocytogenes a...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/S0966-842X(97)01005-6
更新日期：1997-04-01 00:00:00
abstract：:Modern medicine is facing the spread of biofilm-related infections. Bacterial biofilms are difficult to detect in routine diagnostics and are inherently tolerant to host defenses and antibiotic therapies. In addition, biofilms facilitate the spread of antibiotic resistance by promoting horizontal gene transfer. We rev...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2004.11.010
更新日期：2005-01-01 00:00:00
abstract：:Pathogenic viral infections have exerted selection pressure on their hosts to evolve cellular antiviral inhibitors referred to as restriction factors. Examples of such molecules are APOBEC3G, APOBEC3F and TRIM5alpha. APOBEC3G and APOBEC3F are cytidine deaminases that are able to strongly inhibit retroviral replication...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2008.08.013
更新日期：2008-12-01 00:00:00
abstract：:Defensins and cathelicidins are prevalent and essential gastrointestinal cationic antimicrobial peptides (CAPs). However, these defensive peptides are not infallible because certain enteropathogens can overcome their protective function. Furthermore, impaired defensin synthesis has been linked to the occurrence of Cro...
journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/j.tim.2006.08.008
更新日期：2006-10-01 00:00:00
abstract：:Antifungal drug discovery is starting to benefit from the enormous advances in the genomics field, which have occurred in the past decade. As traditional drug screening on existing targets is not delivering the long-awaited potent antifungals, efforts to use novel genetics and genomics-based strategies to aid in the d...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2003.08.008
更新日期：2003-10-01 00:00:00
abstract：:Pathogens survive and propagate within host cells through a wide array of complex interactions. Tracking the molecular and cellular events by multidimensional fluorescence microscopy has been a widespread tool for research on intracellular pathogens. Through major advancements in 3D electron microscopy, intracellular ...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2018.11.011
更新日期：2019-05-01 00:00:00
abstract：:Mycobacterium leprae has the capacity to invade the peripheral nervous system and cause neuropathy. The molecular mechanisms responsible have remained unknown until recently. Identification of the endoneurial laminin-2 isoform and its receptor alpha-dystroglycan as neural targets of M. leprae has not only opened up a ...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/s0966-842x(99)01647-9
更新日期：2000-01-01 00:00:00
abstract：:For more than 70 years electron microscopy (EM) techniques have played an important role in investigating structures of enveloped viruses. By contrast, use of fluorescence microscopy (FM) methods for this purpose was limited by the fact that the size of virus particles is generally around or below the diffraction limi...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2013.06.010
更新日期：2013-10-01 00:00:00
abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is an exogenous retrovirus that persists lifelong in the infected host. Infection has been linked to a spectrum of diverse diseases: adult T cell leukemia, encephalomyelopathy, and predisposition to opportunistic bacterial and helminth infections. Applications of new technolo...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2012.07.004
更新日期：2012-10-01 00:00:00
abstract：:Fungal infections are on the rise due to new medical procedures that have increased the number of immune compromised patients, antibacterial antibiotics that disrupt the microbiome, and increased use of indwelling medical devices that provide sites for biofilm formation. Key to understanding the mechanisms of pathogen...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2020.05.001
更新日期：2020-11-01 00:00:00
abstract：:The increasing availability of whole-genome sequence (WGS) data for Mycobacterium tuberculosis, the bacterium that causes tuberculosis (TB), suggests that circulating genotypes have been molded by three dominant evolutionary forces: long-term persistence within the human population, which requires a core programme of ...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2014.10.005
更新日期：2015-01-01 00:00:00
