Abstract：
:Detection of pathogen-derived nucleic acids by pattern recognition receptors (PRRs) is essential for the host to mount an appropriate immune response, which for viruses involves the induction of type I interferons (IFNs). By contrast, inappropriate activation of PRRs by self nucleic acids can lead to autoimmunity. Recent developments in PRR research have uncovered important new molecular details as to how Toll-like receptors (TLRs) and retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs) distinguish pathogen from self RNA, while the discovery of cytosolic DNA sensing pathways for IFN induction has revealed completely new innate signaling mechanisms, and also questions how innate immunity discriminates between self and non-self DNA, if at all.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Gürtler C,Bowie AGdoi
10.1016/j.tim.2013.04.004subject
Has Abstractpub_date
2013-08-01 00:00:00pages
413-20issue
8eissn
0966-842Xissn
1878-4380pii
S0966-842X(13)00075-9journal_volume
21pub_type
杂志文章,评审abstract：:Passive immunization studies, including a recent one by Pegu et al., have repeatedly shown that HIV-specific broadly neutralizing antibodies (bnAbs) protect rhesus macaques from HIV acquisition. In vitro neutralization potency and in vivo protection correlate very strongly, supporting the quest for an HIV vaccine that...
journal_title：Trends in microbiology
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abstract：:Microbial fuel cells (MFCs) are not yet commercialized but they show great promise as a method of water treatment and as power sources for environmental sensors. The power produced by these systems is currently limited, primarily by high internal (ohmic) resistance. However, improvements in the system architecture wil...
journal_title：Trends in microbiology
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/0966-842x(96)10022-6
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abstract：:Seasonal influenza is controlled through vaccination campaigns. Evolution of influenza virus antigens means that vaccines must be updated to match novel strains, and vaccine effectiveness depends on the ability of scientists to predict nearly a year in advance which influenza variants will dominate in upcoming seasons...
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abstract：:The assembly of microbial communities within the gastrointestinal tract during early life plays a critical role in immune, endocrine, metabolic, and other host developmental pathways. Environmental insults during this period, such as food insecurity and infections, can disrupt this optimal microbial succession, which ...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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更新日期：2019-02-01 00:00:00
abstract：:Type III secretion (T3S) is a mechanism that is central to the biology of the Chlamydiaceae and many other pathogens whose virulence depends on the translocation of toxic effector proteins to cytosolic targets within infected eukaryotic cells. Biomathematical simulations, using a previously described model of contact-...
journal_title：Trends in microbiology
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/s0966-842x(00)01902-8
更新日期：2001-01-01 00:00:00
abstract：:Badgers represent a wildlife reservoir for bovine tuberculosis in Britain, which persists in the south west despite almost 20 years of badger control. The influence of landscape structure on patterns of badger urinatory behaviour may be one reason for the localized persistence of the disease in cattle within the regio...
journal_title：Trends in microbiology
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更新日期：1994-02-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2012.03.009
更新日期：2012-06-01 00:00:00
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
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doi：10.1016/j.tim.2011.06.004
更新日期：2011-09-01 00:00:00
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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journal_title：Trends in microbiology
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journal_title：Trends in microbiology
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更新日期：2019-12-01 00:00:00
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journal_title：Trends in microbiology
pub_type： 杂志文章,评审
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abstract：:Microbial dormancy is a widespread phenomenon employed by bacteria to evade environmental threats including antibiotics. This intrinsic mechanism of antibiotic tolerance has drawn special attention to the role of dormancy in human disease, particularly in regards to recurrent infections. Two dormancy states, the viabl...
journal_title：Trends in microbiology
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更新日期：2015-01-01 00:00:00
abstract：:Measles virus gene expression is attenuated in neural cells by mechanisms that affect both viral transcription and translation. Host enzymes that hypermutate viral genes, and those induced by cytokines, may act cooperatively to slow viral replication and to favor persistent measles virus infections in the human centra...
journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/s0966-842x(00)88976-3
更新日期：1995-09-01 00:00:00
