Abstract:
:Protozoans of the genus Plasmodium are the causative agents of malaria; they have a complex life cycle involving vertebrate and arthropod hosts and have three distinct invasive stages. Although the invasive stages probably invade cells using similar mechanisms, each stage has a different host cell specificity and utilizes different receptors to enter cells.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Sinnis P,Sim BKdoi
10.1016/s0966-842x(97)84657-4subject
Has Abstractpub_date
1997-02-01 00:00:00pages
52-8issue
2eissn
0966-842Xissn
1878-4380pii
S0966842X97846574journal_volume
5pub_type
杂志文章,评审abstract::The major regulator of sporulation initiation in Bacillus subtilis is the phosphorelay, a multicomponent signal transduction system. A myriad of signals, both positive and negative, from the environment, cell cycle and metabolism is received and interpreted by the phosphorelay and integrated through the opposing activ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(98)01350-x
更新日期:1998-09-01 00:00:00
abstract::Spores produced by bacilli and clostridia are surrounded by a multilayered protein shell called the coat. As the armor-like appearance of the coat suggests, this structure, along with others within the spore, confers the remarkable resistance properties that make Bacillus anthracis spores such potent biological weapon...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(02)02373-9
更新日期:2002-06-01 00:00:00
abstract::HIV-1 evades antibody-mediated neutralization in many cunning ways. The recent structural characterization of a conserved neutralization epitope on the envelope glycoprotein complex (Env) provides clues to the vulnerabilities of the virus. We discuss these observations and explain their relevance for HIV-1 vaccine des...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2007.05.006
更新日期:2007-07-01 00:00:00
abstract::Enveloped viruses encode membrane-associated glycoproteins that direct the initial stages of virus infection. These usually oligomeric structures bind virions to cell surface receptors and, subsequently, direct fusion of viral membranes with cellular membranes. These structures are also the primary targets of neutrali...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/s0966-842x(01)01959-x
更新日期:2001-03-01 00:00:00
abstract::Staphylococcus aureus is a major cause of bacteraemia, which frequently leads to infective endocarditis, osteomyelitis, septic arthritis and metastatic abscess formation. The development of these secondary infections is due to bacterial dissemination from the blood into surrounding tissues and is associated with signi...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2010.12.005
更新日期:2011-04-01 00:00:00
abstract::Legionella pneumophila secretes over 300 effector proteins that manipulate host cells. This multiplicity of effectors hampers the characterization of their individual roles. Shames et al. report a new approach to solve the enigma of Legionella effector function by using INSeq to analyse effector functions in the conte...
journal_title:Trends in microbiology
pub_type: 评论,杂志文章
doi:10.1016/j.tim.2018.01.003
更新日期:2018-03-01 00:00:00
abstract::Genomics is fast becoming a routine tool in medical diagnostics and cutting-edge biotechnologies. Yet, its use for environmental biomonitoring is still considered a futuristic ideal. Until now, environmental genomics was mainly used as a replacement of the burdensome morphological identification, to screen known morph...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.10.012
更新日期:2019-05-01 00:00:00
abstract::Genome analyses of double strand DNA tailed bacteriophages argue that they evolve by recombinational reassortment of genes and by the acquisition of novel genes as simple genetic elements termed morons. These processes suggest a model for early virus evolution, wherein viruses can be regarded less as having derived fr...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(00)01863-1
更新日期:2000-11-01 00:00:00
abstract::Viruses that have coevolved with their host establish chronic infections that are well tolerated by the host. Other viruses, that are partly adapted to their host, may induce chronic infections where persistent replication and viral antigen expression occur. The former induce highly functional and resilient CD8T cell ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2017.11.012
更新日期:2018-06-01 00:00:00
abstract::Increasing evidence indicates that Staphylococcus aureus might be a facultative intracellular pathogen. In particular, certain subpopulations, called small colony variants (SCVs), seem to be well adapted to the intracellular milieu. When compared to 'normal' staphylococcal strains, SCVs show increased uptake by host c...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2008.11.004
更新日期:2009-02-01 00:00:00
abstract::DNA damage that blocks the transcription of genes is prioritized for repair by transcription-coupled DNA repair pathways. RNA polymerases stalled at DNA lesions obstruct repair enzymes, but this situation is turned to the advantage of the cell by transcription-repair coupling factors that remove the stalled RNA polyme...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2007.05.005
更新日期:2007-07-01 00:00:00
abstract::Heat-stable enterotoxin, produced by Escherichia coli, binds to particulate guanylate cyclase to increase cyclic GMP in intestinal cells. This in turn stimulates the cyclic-GMP- or cyclic-AMP-dependent protein kinase, activating the same chloride channel that is defective in cystic fibrosis. It is possible that the re...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/0966-842x(94)90541-x
更新日期:1994-03-01 00:00:00
abstract::Bacterial phenotypes are predominantly studied in culture because detection of their specific metabolic pathways in the host is challenging. Development of stable-isotope breath tests, allowing in situ phenotype analyses, may endow diagnostics with new modalities based upon direct monitoring of in vivo microbial metab...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2015.02.013
更新日期:2015-06-01 00:00:00
abstract::Growing concerns about global climate change and energy dependence have led to an increased effort to reduce carbon emissions. A considerable reduction could be achieved by using biofuels from lignocellulosic biomass instead of fossil fuels. One major bottleneck of biofuel production from lignocellulose is the availab...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2008.06.001
更新日期:2008-09-01 00:00:00
abstract::A recent study has provided important clues towards the identity of the host genes that conspire to promote post-integration latency of human immunodeficiency virus (HIV). Various genes controlling transcription, histone deacetylation and proteasome-mediated protein degradation have emerged as potential players. If th...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2005.02.006
更新日期:2005-04-01 00:00:00
abstract::A holistic approach to understanding the mechanisms by which stress influences the pathogenesis of infectious disease has resulted in the development of the field of microbial endocrinology. This transdisciplinary field represents the intersection of microbiology with mammalian endocrinology and neurophysiology, and i...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2007.11.005
更新日期:2008-02-01 00:00:00
abstract::Several features of HIV have frustrated efforts to develop a vaccine able to induce broadly neutralising antibodies. The enormous genetic diversity of HIV is a major factor, accompanied by the camouflaged nature of the envelope spike, upon which HIV depends for cellular entry and to which antibodies must bind to neutr...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2008.08.008
更新日期:2008-12-01 00:00:00
abstract::Although it is commonly assumed that Darwin had nothing to say about microbes, he did in fact say quite a lot. He included microbes in his Beagle studies of the geographical distribution of organisms and used microscopic organisms as explicit exemplars of how adaptation did not imply increasing complexity. Darwin ofte...
journal_title:Trends in microbiology
pub_type: 历史文章,杂志文章
doi:10.1016/j.tim.2009.05.009
更新日期:2009-08-01 00:00:00
abstract::Two recent studies have provided the most complete screen for protein complexes in yeast to date, in which partners were identified for approximately half of the proteome. A comparison shows that these two datasets are complementary. In addition, one of the analyses points to a modular organization of the cellular pro...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2006.06.002
更新日期:2006-08-01 00:00:00
abstract::The susceptibility of Caenorhabditis elegans to different virulent phenotypes of Pseudomonas aeruginosa makes the worms an excellent model for studying host-pathogen interactions. Including the recently described liquid killing, five different killing assays are now available offering superb possibilities for performi...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2013.04.006
更新日期:2013-07-01 00:00:00
abstract::Despite being a curable disease, tuberculosis (TB) killed more people in 2009 than during any previous year in history. Progress in TB research has been slow, and remains burdened by important gaps in our knowledge of the basic biology of Mycobacterium tuberculosis, the causative agent of TB, and its interaction with ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2011.07.002
更新日期:2011-10-01 00:00:00
abstract::Winogradsky discovered in 1890 that nitrification is carried out in two consecutive steps by two distinct groups of bacteria: ammonia-oxidizing bacteria and nitrite-oxidizing bacteria. An explanation for this division of labour is offered based on the kinetic theory of optimal design of metabolic pathways, which postu...
journal_title:Trends in microbiology
pub_type: 社论
doi:10.1016/j.tim.2006.03.006
更新日期:2006-05-01 00:00:00
abstract::Permafrost covers a quarter of the northern hemisphere land surface and contains twice the amount of carbon that is currently present in the atmosphere. Future climate change is expected to reduce its near-surface cover by over 90% by the end of the 21st century, leading to thermokarst lake formation. Thermokarst lake...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2020.04.002
更新日期:2020-09-01 00:00:00
abstract::In bacteria, Ca(2+) is implicated in a wide variety of cellular processes, including the cell cycle and cell division. Dedicated influx and efflux systems tightly control the low cytoplasmic Ca(2+) levels in prokaryotes. Additionally, the growing number of proteins containing various Ca(2+)-binding motifs supports the...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(01)02284-3
更新日期:2002-02-01 00:00:00
abstract::Seasonal influenza is controlled through vaccination campaigns. Evolution of influenza virus antigens means that vaccines must be updated to match novel strains, and vaccine effectiveness depends on the ability of scientists to predict nearly a year in advance which influenza variants will dominate in upcoming seasons...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2017.09.004
更新日期:2018-02-01 00:00:00
abstract::Human influenza viruses cause regular epidemics and occasional pandemics with a substantial public health burden. Household transmission studies have provided valuable information on the dynamics of influenza transmission. We reviewed published studies and found that once one household member is infected with influenz...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2015.10.012
更新日期:2016-02-01 00:00:00
abstract::The Archaea include microorganisms growing in some of the most extreme environments on earth. Consequently, their cellular components are remarkably stable entities and have considerable potential in the biotechnology industry. Here, we review the structure of archaeal enzymes in the context of their ability to functi...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(98)01316-x
更新日期:1998-08-01 00:00:00
abstract::Deeper understanding of the bacteriostatic and bactericidal mechanisms of antimicrobial peptides (AMPs) should help in the design of new antibacterial agents. Over several decades, a variety of biochemical assays have been applied to bulk bacterial cultures. While some of these bulk assays provide time resolution of t...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2015.11.004
更新日期:2016-02-01 00:00:00
abstract::Strictly blood-feeding leeches and their limited microbiota provide natural and powerful model systems to examine symbiosis. Blood is devoid of essential nutrients and it is thought that symbiotic bacteria synthesize these for the host. In this review, three distinct leech-microbe associations are described: (i) the m...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2006.06.009
更新日期:2006-08-01 00:00:00
abstract::There are an estimated 10(31) viruses on Earth, most of which are phages that infect bacteria. Metagenomic analyses have shown that environmental viral communities are incredibly diverse. There are an estimated 5000 viral genotypes in 200 liters of seawater and possibly a million different viral genotypes in one kilog...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2005.04.003
更新日期:2005-06-01 00:00:00