Abstract：
:The assembly of microbial communities within the gastrointestinal tract during early life plays a critical role in immune, endocrine, metabolic, and other host developmental pathways. Environmental insults during this period, such as food insecurity and infections, can disrupt this optimal microbial succession, which may contribute to lifelong and intergenerational deficits in growth and development. Here, we review the human microbiome in the first 1000 days - referring to the period from conception to 2 years of age - and using a developmental model, we examine the role of early microbial succession in growth and development. We propose that an 'undernourished' microbiome is intergenerational, thereby perpetuating growth impairments into successive generations. We also identify and discuss the intertwining host-microbe-environment interactions occurring prenatally and during early infancy, which may impair the trajectories of healthy growth and development, and explore their potential as novel microbial targets for intervention.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Robertson RC,Manges AR,Finlay BB,Prendergast AJdoi
10.1016/j.tim.2018.09.008subject
Has Abstractpub_date
2019-02-01 00:00:00pages
131-147issue
2eissn
0966-842Xissn
1878-4380pii
S0966-842X(18)30204-Xjournal_volume
27pub_type
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