Abstract:
:Human coronaviruses (HCoVs), including SARS-CoV and MERS-CoV, are zoonotic pathogens that originated in wild animals. HCoVs have large genomes that encode a fixed array of structural and nonstructural components, as well as a variety of accessory proteins that differ in number and sequence even among closely related CoVs. Thus, in addition to recombination and mutation, HCoV genomes evolve through gene gains and losses. In this review we summarize recent findings on the molecular evolution of HCoV genomes, with special attention to recombination and adaptive events that generated new viral species and contributed to host shifts and to HCoV emergence. VIDEO ABSTRACT.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Forni D,Cagliani R,Clerici M,Sironi Mdoi
10.1016/j.tim.2016.09.001subject
Has Abstractpub_date
2017-01-01 00:00:00pages
35-48issue
1eissn
0966-842Xissn
1878-4380pii
S0966-842X(16)30133-0journal_volume
25pub_type
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